A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

Filamentous Bacteriophage as a Novel Therapeutic Tool for Alzheimer's Disease Treatment

(2017) Beka Solomon   JOURNAL OF ALZHEIMERS DISEASE

Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice

(2016) Jianping Wang et al.   BRAIN RESEARCH

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls

(2016) Armand Savioz et al.   Neurodegenerative Diseases

Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors

(2016) Ming Cheng et al.   OncoImmunology

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

(2015) Jessica M. Mc Donald et al.   Alzheimers & Dementia

Oligomeric α-synuclein and β-amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

(2015) Stephanie M. Williams et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

Elucidating Molecular Mass and Shape of a Neurotoxic Aβ Oligomer

(2014) Adriano Sebollela et al.   ACS Chemical Neuroscience

Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer’s disease

(2014) Kazuma Murakami   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Functional Characteristics and Molecular Mechanism of a New scFv Antibody Against Aβ42 Oligomers and Immature Protofibrils

(2014) Yuan Zhang et al.   MOLECULAR NEUROBIOLOGY

Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease

(2014) Kirsten L. Viola et al.   Nature Nanotechnology

Conformational targeting of intracellular Aβ oligomers demonstrates their pathological oligomerization inside the endoplasmic reticulum

(2014) Giovanni Meli et al.   Nature Communications

Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

(2014) William F Goure et al.   Alzheimers Research & Therapy

Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples

(2013) Srinath Kasturirangan et al.   BIOTECHNOLOGY PROGRESS

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency

(2013) Geovanny Rivera-Hernández et al.   mAbs

Immunotherapy for Alzheimer’s Disease

(2013) Martin R. Farlow et al.   NEUROLOGIC CLINICS

On the subject of rigor in the study of amyloid β-protein assembly

(2013) David B Teplow   Alzheimers Research & Therapy

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies

(2012) Pauline T. Velasco et al.   ACS Chemical Neuroscience

scFv Antibody: Principles and Clinical Application

(2012) Zuhaida Asra Ahmad et al.   Clinical & Developmental Immunology

A comparative analysis of the aggregation behavior of amyloid-β peptide variants

(2012) Annelies Vandersteen et al.   FEBS LETTERS

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models

(2012) Christopher M. Acker et al.   NEUROBIOLOGY OF AGING

Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses

(2011) Satoko Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Prefibrillar Tau Oligomersin Vitroand in Alzheimer Disease

(2011) Kristina R. Patterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries

(2010) M. Medecigo et al.   JOURNAL OF NEUROIMMUNOLOGY

Generation and Therapeutic Efficacy of Highly Oligomer-Specific  -Amyloid Antibodies

(2010) H. Hillen et al.   JOURNAL OF NEUROSCIENCE

Nanobody specific for oligomeric beta-amyloid stabilizes nontoxic form

(2010) Srinath Kasturirangan et al.   NEUROBIOLOGY OF AGING

Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

(2010) Leonardo M. Saraiva et al.   PLoS One

Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers

(2009) Xiao-ping Wang et al.   FEBS LETTERS

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct in Vivo Intracellular Selection of Conformation-sensitive Antibody Domains Targeting Alzheimer's Amyloid-β Oligomers

(2009) Giovanni Meli et al.   JOURNAL OF MOLECULAR BIOLOGY

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Annular Protofibrils Are a Structurally and Functionally Distinct Type of Amyloid Oligomer

(2008) Rakez Kayed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

(2008) Andleeb Zameer et al.   JOURNAL OF MOLECULAR BIOLOGY

Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42

(2007) R.S. Solórzano-Vargas et al.   MOLECULAR IMMUNOLOGY

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING

Vaccination with soluble Aβ oligomers generates toxicity-neutralizing antibodies

(2003) Mary P. Lambert et al.   JOURNAL OF NEUROCHEMISTRY