Vascular Cognitive Impairment and the Gut Microbiota

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

(2017) Meng-Yu Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment

(2017) Jordan B Jahrling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The diabetic brain and cognition

(2017) Peter Riederer et al.   JOURNAL OF NEURAL TRANSMISSION

Analysis of fecal short chain fatty acid concentration in miniature dachshunds with inflammatory colorectal polyps

(2017) Hirotaka IGARASHI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease

(2017) James A.P. Tomlinson et al.   KIDNEY INTERNATIONAL

The role of short-chain fatty acids in kidney injury induced by gut-derived inflammatory response

(2017) Wei Huang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

(2017) Alan T. Tang et al.   NATURE

A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells

(2017) Laura Giusti et al.   Oxidative Medicine and Cellular Longevity

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentially Severe Cognitive Effects of Compromised Cerebral Blood Flow in Aged Mice: Association with Myelin Degradation and Microglia Activation

(2017) Gilly Wolf et al.   Frontiers in Aging Neuroscience

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta‐Analysis of Prospective Studies

(2017) Yoriko Heianza et al.   Journal of the American Heart Association

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

(2017) Tiejun Li et al.   Frontiers in Physiology

Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain

(2017) Yuhai Zhao et al.   Frontiers in Immunology

Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD

(2017) Mohammed Al-Obaide et al.   Journal of Clinical Medicine

Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke

(2017) Kazuo Yamashiro et al.   PLoS One

Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

(2017) Laura Bonfili et al.   Scientific Reports

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

(2017) Akihiro Kitamura et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation

(2016) Mathilde Guerville et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Saturated fatty acids trigger TLR4-mediated inflammatory response

(2016) D.M. Rocha et al.   ATHEROSCLEROSIS

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway

(2016) Yishu Yang et al.   BRAIN RESEARCH

Clostridium butyricum attenuates cerebral ischemia/reperfusion injury in diabetic mice via modulation of gut microbiota

(2016) Jing Sun et al.   BRAIN RESEARCH

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

TLR ligands and butyrate increasePyyexpression through two distinct but inter-regulated pathways

(2016) Pierre Larraufie et al.   CELLULAR MICROBIOLOGY

Gut Microbiota-brain Axis

(2016) Hong-Xing Wang et al.   CHINESE MEDICAL JOURNAL

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

(2016) Miryam Nava Catorce et al.   Current Neuropharmacology

Trimethylamine-N-oxide

(2016) Aze Wilson et al.   CURRENT OPINION IN LIPIDOLOGY

The role of short-chain fatty acid on blood pressure regulation

(2016) Junki Miyamoto et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Analysis of Gut Microbiota in Coronary Artery Disease Patients: a Possible Link between Gut Microbiota and Coronary Artery Disease

(2016) Takuo Emoto et al.   Journal of Atherosclerosis and Thrombosis

Gut microbiota impact on stroke outcome: Fad or fact?

(2016) Katarzyna Winek et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Association between Helicobacter pylori infection and carotid atherosclerosis in patients with vascular dementia

(2016) Yuzhen Xu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Role of gut microbiota in atherosclerosis

(2016) Annika Lindskog Jonsson et al.   Nature Reviews Cardiology

A Gut Feeling about Thrombosis

(2016) Herbert Tilg   NEW ENGLAND JOURNAL OF MEDICINE

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

Depletion of Cultivatable Gut Microbiota by Broad-Spectrum Antibiotic Pretreatment Worsens Outcome After Murine Stroke

(2016) Katarzyna Winek et al.   STROKE

Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

(2016) Ming-liang Chen et al.   mBio

Human gut microbiota: the links with dementia development

(2016) Rashad Alkasir et al.   Protein & Cell

Microbiota‐Dependent Metabolite Trimethylamine N‐Oxide and Coronary Artery Calcium in the Coronary Artery Risk Development in Young Adults Study (CARDIA)

(2016) Katie A. Meyer et al.   Journal of the American Heart Association

Intestinal Microbiome and Atherosclerosis

(2016) J. David Spence   EBioMedicine

Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans

(2016) Elko Randrianarisoa et al.   Scientific Reports

Obese-type Gut Microbiota Induce Neurobehavioral Changes in the Absence of Obesity

(2015) Annadora J. Bruce-Keller et al.   BIOLOGICAL PSYCHIATRY

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart FailureCLINICAL PERSPECTIVE

(2015) Chelsea L. Organ et al.   Circulation-Heart Failure

TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation

(2015) Licio A. Velloso et al.   ENDOCRINE REVIEWS

Olfaction in the kidney: ‘smelling’ gut microbial metabolites

(2015) Niranjana Natarajan et al.   EXPERIMENTAL PHYSIOLOGY

Protective effects of bifidobacteria on intestines in newborn rats with necrotizing enterocolitis and its regulation on TLR2 and TLR4

(2015) W. Zhou et al.   GENETICS AND MOLECULAR RESEARCH

Is Helicobacter pylori infection a critical risk factor for vascular dementia?

(2015) Yuzhen Xu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

The Characteristics and Function of Bacterial Lipopolysaccharides and Their Endotoxic Potential in Humans

(2015) Anne Gnauck et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Intestinal Microbiota-Dependent Phosphatidylcholine Metabolites, Diastolic Dysfunction, and Adverse Clinical Outcomes in Chronic Systolic Heart Failure

(2015) W.H. Wilson Tang et al.   JOURNAL OF CARDIAC FAILURE

Cellular and molecular biology of aging endothelial cells

(2015) Anthony J. Donato et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015)   LANCET

Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy

(2015) Matthias Schmitz et al.   NEUROBIOLOGY OF AGING

Blood-brain barrier damage in vascular dementia

(2015) Masaki Ueno et al.   NEUROPATHOLOGY

Gut microbiota-derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity

(2015) L. -G. Hersoug et al.   Obesity Reviews

Treating Coronary Disease and the Impact of Endothelial Dysfunction

(2015) Yasushi Matsuzawa et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Fecal microbiota transplantation broadening its application beyond intestinal disorders

(2015) Meng-Que Xu   WORLD JOURNAL OF GASTROENTEROLOGY

Brain-gut-microbiota axis in Parkinson's disease

(2015) Agata Mulak   WORLD JOURNAL OF GASTROENTEROLOGY

Mechanisms Linking Inflammation to Insulin Resistance

(2015) Li Chen et al.   International Journal of Endocrinology

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Neuroprotective Effects ofClostridium butyricumagainst Vascular Dementia in Mice via Metabolic Butyrate

(2015) Jiaming Liu et al.   Biomed Research International

Dysbiosis of Gut Microbiota With Reduced Trimethylamine‐N‐Oxide Level in Patients With Large‐Artery Atherosclerotic Stroke or Transient Ischemic Attack

(2015) Jia Yin et al.   Journal of the American Heart Association

How the Intricate Interaction among Toll-Like Receptors, Microbiota, and Intestinal Immunity Can Influence Gastrointestinal Pathology

(2015) Simona Frosali et al.   Journal of Immunology Research

High-fat diet-induced obesity Rat model: a comparison between Wistar and Sprague-Dawley Rat

(2015) Cláudia Marques et al.   Adipocyte

Intestinal microbiota and faecal transplantation as treatment modality for insulin resistance and type 2 diabetes mellitus

(2014) S. D. Udayappan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The human microbiome and bile acid metabolism: dysbiosis, dysmetabolism, disease and intervention

(2014) Mitchell L Jones et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

(2014) M. Trøseid et al.   JOURNAL OF INTERNAL MEDICINE

Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function

(2014) Katalin Réka Kovács et al.   Journal of the American Society of Hypertension

Endotoxemia of Metabolic Syndrome: A Pivotal Mediator of Meta-Inflammation

(2014) Ishwarlal Jialal et al.   Metabolic Syndrome and Related Disorders

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

(2014) S. A. Joyce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Cognitive Patterns in Relation to Biomarkers of Cerebrovascular Disease and Vascular Risk Factors

(2013) Júlia Miralbell et al.   CEREBROVASCULAR DISEASES

Inflammasomes: sensors of metabolic stresses for vascular inflammation 

(2013) Xiao-feng Yang   Frontiers in Bioscience-Landmark

Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice

(2013) Myung H. Kim et al.   GASTROENTEROLOGY

Therapeutic Potential of Fecal Microbiota Transplantation

(2013) Loek P. Smits et al.   GASTROENTEROLOGY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Probiotics determine hypolipidemic and antioxidant effects in hyperlipidemic hamsters

(2013) Camelia Sorina Stancu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Gut Microbiota on Insulin Resistance

(2013) Andrea Caricilli et al.   Nutrients

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Vascular cognitive impairment

(2012) Fred Rincon et al.   CURRENT OPINION IN NEUROLOGY

Fecal Microbiota Transplantation

(2012) Thomas Julius Borody et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

The gut microbiota, obesity and insulin resistance

(2012) Jian Shen et al.   MOLECULAR ASPECTS OF MEDICINE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Immuno-microbiota cross and talk: The new paradigm of metabolic diseases

(2012) Rémy Burcelin et al.   SEMINARS IN IMMUNOLOGY

Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood–brain barrier via TLR4/IRF-3 signaling

(2012) Jeong June Choi et al.   TOXICOLOGY

Short chain fatty acids and their receptors: new metabolic targets

(2012) Brian T. Layden et al.   Translational Research

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Shiga Toxin 1 Induces on Lipopolysaccharide-Treated Astrocytes the Release of Tumor Necrosis Factor-alpha that Alter Brain-Like Endothelium Integrity

(2012) Verónica I. Landoni et al.   PLoS Pathogens

Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!

(2011) Frederic A. Carvalho et al.   Annual Review of Physiology

Treating Clostridium difficile Infection With Fecal Microbiota Transplantation

(2011) Johan S. Bakken et al.   Clinical Gastroenterology and Hepatology

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus

(2011) R. S. Kootte et al.   DIABETES OBESITY & METABOLISM

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments

(2011) Yoo Kyeong Hwang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Attenuation of vascular dementia by sodium butyrate in streptozotocin diabetic rats

(2011) Bhupesh Sharma et al.   PSYCHOPHARMACOLOGY

Regulation of Inflammation by Short Chain Fatty Acids

(2011) Marco A.R. Vinolo et al.   Nutrients

Brain?Gut?Microbe Communication in Health and Disease

(2011) Sue Grenham et al.   Frontiers in Physiology

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Human oral, gut, and plaque microbiota in patients with atherosclerosis

(2010) O. Koren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood–Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice

(2008) Tsuyoshi Nishioku et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Human metabolic phenotype diversity and its association with diet and blood pressure

(2008) Elaine Holmes et al.   NATURE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and White Matter Damage in Vascular Cognitive Impairment

(2008) G. A. Rosenberg   STROKE