Article
Pediatrics
Tianjing Liu, Haifeng Zong, Xiaoyu Chen, Sihang Li, Ziyun Liu, Xuewei Cui, Guoqiang Jia, Yongyan Shi
Summary: The study indicates that necroptosis is an essential pathological process of NEC, with TLR4 possibly acting as a stimulator. Inhibiting intestinal cell necroptosis may be a beneficial strategy in the treatment of NEC.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Shiloh R. Lueschow, Timothy J. Boly, Steven A. Frese, Giorgio Casaburi, Ryan D. Mitchell, Bethany M. Henrick, Steven J. McElroy
Summary: Necrotizing enterocolitis (NEC) is a disease that primarily affects preterm infants and has limited treatment options. Recent research suggests that the probiotic B. infantis EVC001 can prevent NEC by reducing inflammation and promoting epithelial barrier restoration.
Article
Immunology
Erbu Yarci, Cuneyt Tayman, Didem Ozturk Yarci, Ufuk Cakir, Ataman Gonel, Tugba Taskin Turkmenoglu
Summary: Tocilizumab showed positive effects in preventing and treating NEC, significantly reducing tissue damage and apoptosis, and lowering clinical sickness score. It could be a potential option for the management of NEC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Anatomy & Morphology
Yanhong Mi, Xiaoxiao Xie, Zhongkun Bao, Xiaoyu Xiong, Xinhong Wang, Hongxi Zhang
Summary: The study aimed to investigate the protective effect of dimethyl fumarate (DMF) on necrotizing enterocolitis (NEC) and its mechanism. Results showed that DMF attenuated NEC-induced weight loss and abdominal distension diarrhea, alleviated intestinal pathological injuries, and inhibited intestinal cell apoptosis. These effects were related to the inhibition of the TLR signaling pathway and alleviation of the inflammatory response.
Article
Biochemistry & Molecular Biology
Wenjuan Chen, Yanjie Chen, Yun Qian, Jun Zhang, Xiaoshan Hu, Xiangyun Yan, Chengyao Jiang, Shuwen Yao, Qinlei Yu, Xiaohui Chen, Shuping Han
Summary: This study investigated the protective effects of casein-derived peptide YFYPEL on necrotizing enterocolitis (NEC). YFYPEL integration in the intestine increased survival and clinical conditions, lowered the incidence of NEC, alleviated bowel inflammation, and enhanced intestinal cell migration.
Article
Gastroenterology & Hepatology
Chhinder P. Sodhi, Raheel Ahmad, Hongpeng Jia, William B. Fulton, Carla Lopez, Andres J. Gonzalez Salazar, Asuka Ishiyama, Maame Sampah, Steve Steinway, Sanxia Wang, Thomas Prindle, Menghan Wang, David L. Steed, Howard Wessel, Ziv Kirshner, Larry R. Brown, Peng Lu, David J. Hackam
Summary: This study shows that the secreted product of amniotic progenitor cells, ST266, can prevent and treat necrotizing enterocolitis (NEC) through inhibiting Toll-like receptor 4 (TLR4) signaling, and also affects important genes associated with gut remodeling, immunity, and metabolism. These findings suggest that the amniotic secretome may offer novel therapeutic approaches for NEC.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Pediatrics
Alain Cuna, Venkatesh Sampath, Minesh Khashu
Summary: NEC is a serious disease affecting premature infants, with varying rates and outcomes among different racial and ethnic groups. Research on racial disparities in NEC is limited and suggests that Hispanic ethnicity and non-Hispanic Black race may be associated with higher risk. Further studies are needed to fully understand the complex interactions between social and biological factors contributing to these disparities.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Charlotte J. Neumann, Alexander Mahnert, Christina Kumpitsch, Raymond Kiu, Matthew J. Dalby, Magdalena Kujawska, Tobias Madl, Stefan Kurath-Koller, Berndt Urlesberger, Bernhard Resch, Lindsay J. Hall, Christine Moissl-Eichinger
Summary: The study analyzes the effects of three preventive regimens on the gut microbiome development in preterm infants at risk for necrotizing enterocolitis. The use of probiotic Bifidobacterium longum subsp. infantis NCDO 2203 in combination with human milk oligosaccharides has a significant impact on the microbiome and reduces antibiotic resistance.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Qin Chen, Weiquan Yao, Fengdan Xu, Jinfeng Liao, Jinfeng Li, Minling Mai, Haoqiang Xie, Xiaoguang He, Ning Li
Summary: This study focused on the utility of abdominal ultrasound (AUS) in the diagnosis and evaluation of surgical necrotizing enterocolitis (NEC). The results showed that AUS has a high sensitivity and specificity in diagnosing NEC with perforation, and it can effectively monitor and evaluate the progression and complications of the disease.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Jumana Samara, Shirin Moossavi, Belal Alshaikh, Van A. Ortega, Veronika Kucharova Pettersen, Tahsin Ferdous, Suzie L. Hoops, Amuchou Soraisham, Joseph Vayalumkal, Deonne Dersch-Mills, Jeffrey S. Gerber, Sagori Mukhopadhyay, Karen Puopolo, Thomas A. Tompkins, Dan Knights, Jens Walter, Harish Amin, Marie-Claire Arrieta
Summary: Probiotics have positive effects on gut microbiome assembly and immunity in premature infants, accelerating microbiome maturation and improving intestinal immune environment.
CELL HOST & MICROBE
(2022)
Article
Medicine, General & Internal
Jelena R. Cekovic, Nikola S. Prodanovic, Sara S. Mijailovic, Sanja M. Knezevic, Biljana P. Vuletic, Andjelka K. Stojkovic, Dragana M. Savic, Tijana Prodanovic, Marina M. Stanojevic, Aleksandra M. Simovic
Summary: This study investigated the impact of perinatal factors on fecal calprotectin levels in preterm infants. The results showed that calprotectin levels were positively correlated with female infants, intrauterine growth restriction, significant ductus arteriosus, enteral feeding intolerance, prolonged use of broad-spectrum antibiotics, and bicarbonate levels. Measuring calprotectin levels within the first 7 days after birth can aid in the early detection of intestinal distress or necrotizing enterocolitis in premature infants.
Article
Nutrition & Dietetics
Lila S. Nolan, Angela N. Lewis, Qingqing Gong, James J. Sollome, Olivia N. DeWitt, Robert D. Williams, Misty Good
Summary: Metabolomics analysis of breast milk from mothers of preterm infants revealed significant differences in metabolites related to fatty acid metabolism, oligosaccharides, amino sugars, amino acids, vitamins, and oxidative stress between mothers of infants with different birth weights. Understanding these differences may provide insights into tailored nutrition and care for preterm newborns in the future.
Review
Pediatrics
Yan Su, Rui-Hong Xu, Li-Yan Guo, Xin-Qing Chen, Wen-Xiao Han, Jin-Jin Ma, Jiao-Jiao Liang, Ling Hao, Chang-Jun Ren
Summary: The objective of this study was to identify the risk factors for necrotizing enterocolitis (NEC) in neonates through a meta-analysis and provide a reference for prevention. The meta-analysis showed that gestational diabetes, premature rupture of membranes, low birth weight, small for gestational age, septicemia, blood transfusion, congenital heart disease, respiratory distress syndrome, premature birth, and pneumonia were risk factors for NEC in neonates. Breastfeeding, taking probiotics, prenatal use of glucocorticoids, and Hyperbilirubinemia were protective factors for NEC in neonates.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Ji Sook Park, Jin Su Jun, Jae Young Cho, Jung Sook Yeom, Ji-Hyun Seo, Jae Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Summary: This study investigated the role of macrophage migration inhibitory factor (MIF) and its associated clinical factors in neonates. The findings showed significantly higher levels of MIF in preterm infants born before 34 weeks of gestation and in infants with necrotizing enterocolitis (NEC).
Article
Nutrition & Dietetics
Wenting Zhang, Jingqiu He-Yang, Wenjuan Tu, Xiaoying Zhou
Summary: The study demonstrated the involvement of NLRP3 inflammasome in NEC pathology, and showed that the protective effects of SHMOs may be due to the suppression of TLR4/NF-kappa B/NLRP3-mediated inflammation in NEC.
NUTRITION & METABOLISM
(2021)