Journal
METABOLIC SYNDROME AND RELATED DISORDERS
Volume 12, Issue 9, Pages 454-456Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/met.2014.1504
Keywords
-
Categories
Ask authors/readers for more resources
Endotoxemia, which is now emerging as a feature of metabolic syndrome, is believed to contribute to the chronic low-grade inflammatory status and insulin resistance of the syndrome. Lipopolysaccharides (LPS), or endotoxins, bind to LPS-binding protein and activate pattern recognition receptors, classically Toll-like receptor-4, mediating inflammation. Increased gut permeability and changes in composition and diversity of gut microbiome have been proposed as possible mechanisms to explain increased circulating endotoxins in metabolic syndrome. Endotoxins are also believed to be delivered into the circulation by chylomicrons. Weight loss and probiotic and prebiotic therapeutic strategies can reduce endotoxemia, inflammation, and insulin resistance in metabolic syndrome.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available