The Characteristics and Function of Bacterial Lipopolysaccharides and Their Endotoxic Potential in Humans

Dual Signaling of MyD88 and TRIF Is Critical for Maximal TLR4-Induced Dendritic Cell Maturation

(2014) H. Shen et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharides with Acylation Defects Potentiate TLR4 Signaling and Shape T Cell Responses

(2013) Anna Martirosyan et al.   PLoS One

Subjects with Low Plasma HDL Cholesterol Levels Are Characterized by an Inflammatory and Oxidative Phenotype

(2013) Kirsten B. Holven et al.   PLoS One

Intestinal alkaline phosphatase prevents metabolic syndrome in mice

(2013) K. Kaliannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance to lipopolysaccharide promotes an enhanced neutrophil extracellular traps formation leading to a more efficient bacterial clearance in mice

(2012) V. I. Landoni et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions

(2012) David A. Shifrin et al.   CURRENT BIOLOGY

Evasion of human innate immunity without antagonizing TLR4 by mutant Salmonella enterica serovar Typhimurium having penta-acylated lipid A

(2012) Motohiro Matsuura et al.   Innate Immunity

Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide

(2012) U. Maitra et al.   JOURNAL OF IMMUNOLOGY

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic response of immune signalling pathways in intestinal epithelial cells exposed to lipopolysaccharides, Gram-negative bacteria or potentially probiotic microbes

(2012) J. Audy et al.   Beneficial Microbes

Effects of Differences in Lipid A Structure on TLR4 Pro-Inflammatory Signaling and Inflammasome Activation

(2012) Paula M. Chilton et al.   Frontiers in Immunology

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation

(2011) Mariann I. Lassenius et al.   DIABETES CARE

Endotoxemia Is Associated With an Increased Risk of Incident Diabetes

(2011) P. J. Pussinen et al.   DIABETES CARE

Epithelial barrier: an interface for the cross-communication between gut flora and immune system

(2011) Yoshiyuki Goto et al.   IMMUNOLOGICAL REVIEWS

The Transport and Inactivation Kinetics of Bacterial Lipopolysaccharide Influence Its Immunological Potency In Vivo

(2011) M. Lu et al.   JOURNAL OF IMMUNOLOGY

Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase

(2010) Kathryn T. Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3

(2010) R. Deopurkar et al.   DIABETES CARE

A Role for Intestinal Alkaline Phosphatase in the Maintenance of Local Gut Immunity

(2010) Kathryn T. Chen et al.   DIGESTIVE DISEASES AND SCIENCES

The Lipid A Phosphate Position Determines Differential Host Toll-Like Receptor 4 Responses to Phylogenetically Related Symbiotic and Pathogenic Bacteria

(2010) Stephen R. Coats et al.   INFECTION AND IMMUNITY

Gut Microbiota in Health and Disease

(2010) Inna Sekirov et al.   PHYSIOLOGICAL REVIEWS

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins

(2009) Susan Carpenter et al.   BIOCHEMICAL JOURNAL

BacteroidesInduce Higher IgA Production ThanLactobacillusby Increasing Activation-Induced Cytidine Deaminase Expression in B Cells in Murine Peyer’s Patches

(2009) Tsutomu YANAGIBASHI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Immunomodulatory Effects of Yersinia pestis Lipopolysaccharides on Human Macrophages

(2009) M. Matsuura et al.   Clinical and Vaccine Immunology

Development of endotoxin tolerance in humans in vivo

(2009) Annelies Draisma et al.   CRITICAL CARE MEDICINE

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

(2009) N. N. Mehta et al.   DIABETES

Increase in Plasma Endotoxin Concentrations and the Expression of Toll-Like Receptors and Suppressor of Cytokine Signaling-3 in Mononuclear Cells After a High-Fat, High-Carbohydrate Meal: Implications for insulin resistance

(2009) H. Ghanim et al.   DIABETES CARE

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells

(2009) T. Gutsmann et al.   Innate Immunity

Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis

(2009) Arunan S. Vamadevan et al.   Innate Immunity

Selective Activation of the p38 MAPK Pathway by Synthetic Monophosphoryl Lipid A

(2009) Caglar Cekic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients

(2009) Carlos del Fresno et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice

(2008) Tomas Hrncir et al.   BMC IMMUNOLOGY

Host Inactivation of Bacterial Lipopolysaccharide Prevents Prolonged Tolerance Following Gram-Negative Bacterial Infection

(2008) Mingfang Lu et al.   Cell Host & Microbe

Cross-talk among Toll-like receptors and their ligands

(2008) M. Palazzo et al.   INTERNATIONAL IMMUNOLOGY

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

(2008) R. F. Goldberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA