The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice

Effects of obesity on depression: A role for inflammation and the gut microbiota

(2018) Julieta Schachter et al.   BRAIN BEHAVIOR AND IMMUNITY

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

(2018) Jun Wang et al.   Nature Communications

Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB

(2017) Qian Liu et al.   FASEB JOURNAL

Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation

(2017) Gonçalo Garcia et al.   FOOD CHEMISTRY

The Gut Microbiota and Alzheimer’s Disease

(2017) Chunmei Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

Mediterranean diet impact on cardiovascular diseases

(2017) Anna V. Mattioli et al.   Journal of Cardiovascular Medicine

Preliminary Evidence for an Association Between the Composition of the Gut Microbiome and Cognitive Function in Neurologically Healthy Older Adults

(2017) Lisa Manderino et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

The effect of obesity and repeated exposure on pharmacokinetic response to grape polyphenols in humans

(2017) Janet A. Novotny et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function

(2017) Laura Mele et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols

(2017) Lap Ho et al.   MOLECULAR PHARMACEUTICS

Metagenomic binning and association of plasmids with bacterial host genomes using DNA methylation

(2017) John Beaulaurier et al.   NATURE BIOTECHNOLOGY

Evaluation of dietary and lifestyle changes as modifiers of S100β levels in Alzheimer’s disease

(2017) Nathan M. D’Cunha et al.   NUTRITIONAL NEUROSCIENCE

Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid

(2017) Aimee N. Winter et al.   Oxidative Medicine and Cellular Longevity

Intake of total saponins and polysaccharides from Polygonatum kingianum affects the gut microbiota in diabetic rats

(2017) Hongli Yan et al.   PHYTOMEDICINE

Enzymatic activity necessary to restore the lethality due to Escherichia coli RNase E deficiency is distributed among bacteria lacking RNase E homologues

(2017) Masaru Tamura et al.   PLoS One

Potential antiproliferative activity of polyphenol metabolites against human breast cancer cells and their urine excretion pattern in healthy subjects following acute intake of a polyphenol-rich juice of grumixama (Eugenia brasiliensis Lam.)

(2017) L. L. Teixeira et al.   Food & Function

Grape Seed Polyphenolic Extract as a Potential Novel Therapeutic Agent in Tauopathies

(2017) Lap Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease

(2017) Jun Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing

(2017) Kate Lawrence et al.   PLoS One

PROTECTIVE ROLES OF INTESTINAL MICROBIOTA IN ALZHEIMER’S DISEASE THROUGH MECHANISMS INVOLVING SHORT CHAIN FATTY ACIDS AND PHENOLIC ACIDS

(2016) Lap Ho et al.   Alzheimers & Dementia

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

(2016) Aedín Cassidy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A community-based lifestyle and weight loss intervention promoting a Mediterranean-style diet pattern evaluated in the stroke belt of North Carolina: the Heart Healthy Lenoir Project

(2016) Thomas C. Keyserling et al.   BMC PUBLIC HEALTH

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Gut microbiota signatures of longevity

(2016) Fanli Kong et al.   CURRENT BIOLOGY

Gut Microbiota and Extreme Longevity

(2016) Elena Biagi et al.   CURRENT BIOLOGY

Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system

(2016) Hae Ung Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cyanidin-3-glucoside and its phenolic acid metabolites attenuate visible light-induced retinal degeneration in vivo via activation of Nrf2/HO-1 pathway and NF-κB suppression

(2016) Yong Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Recommendations for Development of Botanical Polyphenols as “Natural Drugs” for Promotion of Resilience Against Stress-Induced Depression and Cognitive Impairment

(2016) Libby Ward et al.   NEUROMOLECULAR MEDICINE

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

Antioxidant, anti-inflammatory and anti-septic potential of phenolic acids and flavonoid fractions isolated from Lolium multiflorum

(2016) Ki-Choon Choi et al.   PHARMACEUTICAL BIOLOGY

Natural Phyto-Bioactive Compounds for the Treatment of Type 2 Diabetes: Inflammation as a Target

(2016) Sivapragasam Gothai et al.   Nutrients

The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility

(2016) Tugba Ozdal et al.   Nutrients

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

(2016) Shadi S Yarandi et al.   Journal of Neurogastroenterology and Motility

Bioengineered Colorectal Cancer Drugs: Orally Delivered Anti-Inflammatory Agents

(2015) Aleksandra Malgorzata Urbanska et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans

(2015) Shama V. Joseph et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization

(2015) Dongjie Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Flavonoid metabolites reduce tumor necrosis factor-α secretion to a greater extent than their precursor compounds in human THP-1 monocytes

(2015) Jessica L. di Gesso et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The tantalizing links between gut microbes and the brain

(2015) Peter Andrey Smith   NATURE

Novel application of brain-targeting polyphenol compounds in sleep deprivation-induced cognitive dysfunction

(2015) Wei Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

Anti-inflammatory effect of anthocyanins via modulation of nuclear factor- B and mitogen-activated protein kinase signaling cascades

(2015) S. Vendrame et al.   NUTRITION REVIEWS

Phytochemical constituents as future antidepressants: a comprehensive review

(2015) Roodabeh Bahramsoltani et al.   REVIEWS IN THE NEUROSCIENCES

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Microbiota and host determinants of behavioural phenotype in maternally separated mice

(2015) G. De Palma et al.   Nature Communications

Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants

(2015) Antonella Sgarbossa et al.   Nutrients

Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties

(2015) Laura Marín et al.   Biomed Research International

Polyphenols: Well Beyond The Antioxidant Capacity: Polyphenol Supplementation and Exercise-Induced Oxidative Stress and Inflammation

(2014) Antoni Sureda et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Microbiota and diabetes: an evolving relationship

(2014) Herbert Tilg et al.   GUT

The Cardioprotective Effect of Protocatechuic Acid on Myocardial Ischemia/Reperfusion Injury

(2014) Xi-Lan Tang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Influence of Gut Microbiota-Derived Ellagitanninsʼ Metabolites Urolithins on Pro-Inflammatory Activities of Human Neutrophils

(2014) Jakub Piwowarski et al.   PLANTA MEDICA

Identifying Gut Microbe-Host Phenotype Relationships Using Combinatorial Communities in Gnotobiotic Mice

(2014) J. J. Faith et al.   Science Translational Medicine

Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species

(2014) María V. Selma et al.   Food & Function

Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer's disease-experimental approach and therapeutic implications

(2014) Jun Wang et al.   Frontiers in Aging Neuroscience

In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota

(2013) Lisa M Bode et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fecal microbial metabolism of polyphenols and its effects on human gut microbiota

(2013) Shanthi G. Parkar et al.   ANAEROBE

Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model

(2013) Jun Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Antitumor activity of caffeic acid 3,4-dihydroxyphenethyl ester and its pharmacokinetic and metabolic properties

(2013) Xin Guo et al.   PHYTOMEDICINE

Metabolic niche of a prominent sulfate-reducing human gut bacterium

(2013) F. E. Rey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

Defining a Healthy Human Gut Microbiome: Current Concepts, Future Directions, and Clinical Applications

(2012) Fredrik Bäckhed et al.   Cell Host & Microbe

Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches

(2012) Anna-Marja Aura et al.   EUROPEAN JOURNAL OF NUTRITION

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

In vitrofermentation of grape seed flavan-3-ol fractions by human faecal microbiota: changes in microbial groups and phenolic metabolites

(2012) Carolina Cueva et al.   FEMS MICROBIOLOGY ECOLOGY

In Vitro Fermentation of a Red Wine Extract by Human Gut Microbiota: Changes in Microbial Groups and Formation of Phenolic Metabolites

(2012) Fernando Sánchez-Patán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Carrot β-Carotene Degradation and Isomerization Kinetics during Thermal Processing in the Presence of Oil

(2012) Griet Knockaert et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ferulic Acid Improves Cardiovascular and Kidney Structure and Function in Hypertensive Rats

(2012) Md. Ashraful Alam et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Colonic Metabolism of Polyphenols From Coffee, Green Tea, and Hazelnut Skins

(2012) Luca Calani et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

(2012) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Biosynthesis of caffeic acid in Escherichia coli using its endogenous hydroxylase complex

(2012) Yuheng Lin et al.   Microbial Cell Factories

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

The Microbiota Is Essential for the Generation of Black Tea Theaflavins-Derived Metabolites

(2012) Huadong Chen et al.   PLoS One

Colonic catabolism of dietary phenolic and polyphenolic compounds from Concord grape juice

(2012) Angelique Stalmach et al.   Food & Function

Neuroprotective and metabolic effects of resveratrol: Therapeutic implications for Huntington's disease and other neurodegenerative disorders

(2011) Giulio Maria Pasinetti et al.   EXPERIMENTAL NEUROLOGY

Effect of grape polyphenols on lactic acid bacteria and bifidobacteria growth: Resistance and metabolism

(2011) Raquel Tabasco et al.   FOOD MICROBIOLOGY

Isolation of catechin-converting human intestinal bacteria

(2011) M. Kutschera et al.   JOURNAL OF APPLIED MICROBIOLOGY

Structural identification of mouse fecal metabolites of theaflavin 3,3′-digallate using liquid chromatography tandem mass spectrometry

(2011) Huadong Chen et al.   JOURNAL OF CHROMATOGRAPHY A

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

(2011) David J Kupfer et al.   LANCET

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

GSPE interferes with tau aggregation in vivo: implication for treating tauopathy

(2011) Ismael Santa-Maria et al.   NEUROBIOLOGY OF AGING

Identification of microbial metabolites derived from in vitro fecal fermentation of different polyphenolic food sources

(2011) Margherita Dall'Asta et al.   NUTRITION

Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice

(2011) A. L. Goodman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive Compounds in Cranberries and their Biological Properties

(2010) J. Côté et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding

(2010) Lap Ho et al.   Expert Review of Proteomics

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery

(2010) J. K. Marshall et al.   GUT

In Vitro Bioconversion of Polyphenols from Black Tea and Red Wine/Grape Juice by Human Intestinal Microbiota Displays Strong Interindividual Variability

(2010) Gabriele Gross et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Reconsidering anhedonia in depression: Lessons from translational neuroscience

(2010) Michael T. Treadway et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Bioavailability and catabolism of green tea flavan-3-ols in humans

(2010) Daniele Del Rio et al.   NUTRITION

Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites

(2010) Maria Monagas et al.   Food & Function

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Chemotherapy Treatment in Pediatric Patients with Acute Myeloid Leukemia Receiving Antimicrobial Prophylaxis Leads to a Relative Increase of Colonization with Potentially Pathogenic Bacteria in the Gut

(2009) Michel J. van Vliet et al.   CLINICAL INFECTIOUS DISEASES

A comparison of the in vitro biotransformation of (-)-epicatechin and procyanidin B2 by human faecal microbiota

(2009) Stavroula Stoupi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Neural representation of reward in recovered depressed patients

(2009) Ciara McCabe et al.   PSYCHOPHARMACOLOGY

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

(2009) P. J. Turnbaugh et al.   Science Translational Medicine

Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity

(2008) Kenjiro Ono et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE