Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB

NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease

(2016) Viviana Triaca et al.   AGING CELL

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

(2016) Miryam Nava Catorce et al.   Current Neuropharmacology

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Membrane Damage Induced by Amyloid Beta and a Potential Link with Neuroinflammation

(2016) Eduardo J. Fernandez-Perez et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotective Role of Natural Polyphenols

(2016) Carmela Spagnuolo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacokinetics, tissue distribution, and plasma protein binding study of chicoric acid by HPLC–MS/MS

(2016) Yutang Wang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

(2016) Sandro Dá Mesquita et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Hydrogen sulfide down-regulates BACE1 and PS1 via activating PI3K/Akt pathway in the brain of APP/PS1 transgenic mouse

(2016) Xuan-li He et al.   Pharmacological Reports

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis

(2015) Kimberley Ruxton et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Molecular mechanisms linking amyloid β toxicity and Tau hyperphosphorylation in Alzheimer׳s disease

(2015) A. Lloret et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells

(2015) Di Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9

(2015) Mar Hernandez-Guillamon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Bee venom ameliorates lipopolysaccharide-induced memory loss by preventing NF-kappaB pathway

(2015) Sun Mi Gu et al.   Journal of Neuroinflammation

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Evaluation of the Role of JNK1 in the Hippocampus in an Experimental Model of Familial Alzheimer’s Disease

(2015) Dmitry Petrov et al.   MOLECULAR NEUROBIOLOGY

Lutein suppresses inflammatory responses through Nrf2 activation and NF-κB inactivation in lipopolysaccharide-stimulated BV-2 microglia

(2015) Wanqiang Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis

(2015) Moonhee Lee et al.   NEUROBIOLOGY OF AGING

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Checks and balances on cholinergic signaling in brain and body function

(2015) Hermona Soreq   TRENDS IN NEUROSCIENCES

Metabolism of chicoric acid by rat liver microsomes and bioactivity comparisons of chicoric acid and its metabolites

(2015) Qian Liu et al.   Food & Function

Cholinergic System Dysfunction and Neurodegenerative Diseases: Cause or Effect?

(2014) Ada Tata et al.   CNS & Neurological Disorders-Drug Targets

Chicoric acid prevents obesity by attenuating hepatic steatosis, inflammation and oxidative stress in high-fat diet-fed mice

(2013) Haifang Xiao et al.   FOOD RESEARCH INTERNATIONAL

Chicoric Acid Induces Apoptosis in 3T3-L1 Preadipocytes through ROS-Mediated PI3K/Akt and MAPK Signaling Pathways

(2013) Haifang Xiao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

3,4,5-Trihydroxycinnamic Acid Inhibits LPS-Induced iNOS Expression by Suppressing NF-κB Activation in BV2 Microglial Cells

(2012) Jae-Won Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-κB translocation in LPS stimulated RAW 264.7 cells

(2011) Chung Mu Park et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease

(2011) Chia-Hsiung Chen et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Chicoric acid regulates behavioral and biochemical alterations induced by chronic stress in experimental Swiss albino mice

(2011) Kiranjeet Kour et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Evidence for a cytokine model of cognitive function

(2008) J. McAfoose et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-κB pathways

(2007) Yingming Jiang et al.   MOLECULAR IMMUNOLOGY