Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT

Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α–Dependent Manner

(2018) Andrea L. Frump et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Physiological functions of FBW7 in cancer and metabolism

(2018) Kouhei Shimizu et al.   CELLULAR SIGNALLING

Notch after cleavage

(2018) Sarah J Bray et al.   CURRENT OPINION IN CELL BIOLOGY

Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics

(2018) Maria J. Gomez-Lamarca et al.   DEVELOPMENTAL CELL

Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives

(2018) Matthias Barton et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs)

(2018) Rosamaria Lappano et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Oncostatin M upregulates HIF-1α in breast tumor associated macrophages independent of intracellular oxygen concentration

(2018) Richa Shrivastava et al.   LIFE SCIENCES

Bisphenol A induces proliferative effects on both breast cancer cells and vascular endothelial cells through a shared GPER-dependent pathway in hypoxia

(2017) Fangyi Xu et al.   ENVIRONMENTAL POLLUTION

The interplay between the cellular hypoxic response and Notch signaling

(2017) Sebastian K.-J. Landor et al.   EXPERIMENTAL CELL RESEARCH

Estrogen stabilizes hypoxia-inducible factor 1α through G protein-coupled estrogen receptor 1 in eutopic endometrium of endometriosis

(2017) Ling Zhang et al.   FERTILITY AND STERILITY

Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure

(2017) Kota Fujiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-222 Expression as a Predictive Marker for Tumor Progression in Hormone Receptor-Positive Breast Cancer

(2017) Song-Hee Han et al.   Journal of Breast Cancer

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Estrogen receptor β2 induces proliferation and invasiveness of triple negative breast cancer cells: association with regulation of PHD3 and HIF-1α

(2017) Lucia Bialesova et al.   Oncotarget

The zinc-finger transcriptional factor Slug transcriptionally downregulates ERα by recruiting lysine-specific demethylase 1 in human breast cancer

(2017) J-W Bai et al.   Oncogenesis

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

(2017) Luisa Iommarini et al.   Frontiers in Oncology

Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9

(2017) Bae-Jung Choi et al.   Scientific Reports

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

(2016) Tilman Borggrefe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulation of HIF-1α stability by lysine methylation

(2016) Sung Hee Baek et al.   BMB Reports

Reprogramming carcinoma associated fibroblasts by AC1MMYR2 impedes tumor metastasis and improves chemotherapy efficacy

(2016) Yu Ren et al.   CANCER LETTERS

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

(2016) L. Astudillo et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

The G protein estrogen receptor (GPER) is regulated by endothelin-1 mediated signaling in cancer cells

(2016) Viviana Bartella et al.   CELLULAR SIGNALLING

Notch and TGFβ form a positive regulatory loop and regulate EMT in epithelial ovarian cancer cells

(2016) Jiesi Zhou et al.   CELLULAR SIGNALLING

Activation of GPER suppresses epithelial mesenchymal transition of triple negative breast cancer cells via NF-κB signals

(2016) Zhuo-Jia Chen et al.   Molecular Oncology

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance

(2016) T Yu et al.   ONCOGENE

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Estrogen-dependent downregulation of hypoxia-inducible factor (HIF)-2α in invasive breast cancer cells

(2016) Jerry H. Fuady et al.   Oncotarget

Targeting hypoxic response for cancer therapy

(2016) Elisa Paolicchi et al.   Oncotarget

Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

(2016) Aixiu Qiao et al.   Frontiers of Medicine

GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

(2016) Paola De Marco et al.   Scientific Reports

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer

(2015) F. Kuhnert et al.   CANCER RESEARCH

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis

(2015) Z. Liu et al.   DEVELOPMENT

Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation

(2015) L. Skalska et al.   EMBO JOURNAL

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

(2015) C. D. Madsen et al.   EMBO REPORTS

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

(2015) Kanae Yumimoto et al.   JOURNAL OF CLINICAL INVESTIGATION

Estrogen regulates Hippo signaling via GPER in breast cancer

(2015) Xin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF

(2015) Tamar Golan et al.   MOLECULAR CELL

GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependent manner

(2015) JUAN REN et al.   ONCOLOGY REPORTS

Role of the Tumor Microenvironment in Breast Cancer

(2015) Savas D. Soysal et al.   PATHOBIOLOGY

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer

(2015) Jun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision

(2015) Marcelo Boareto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-Independent Mechanisms of Notch Activity

(2015) William Hunt Palmer et al.   TRENDS IN CELL BIOLOGY

Hypoxia-inducible factors in cancer stem cells and inflammation

(2015) Gong Peng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Interleukin-6 and pro inflammatory status in the breast tumor microenvironment

(2015) Alessandro Sanguinetti et al.   World Journal of Surgical Oncology

Basal and therapy-driven hypoxia-inducible factor-1α confers resistance to endocrine therapy in estrogen receptor-positive breast

(2015) Xiaoqing Jia et al.   Oncotarget

The PHD2 oxygen sensor paves the way to metastasis

(2015) Anna Kuchnio et al.   Oncotarget

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

(2015) Damiano Cosimo Rigiracciolo et al.   Oncotarget

HIF-1α pathway: role, regulation and intervention for cancer therapy

(2015) Georgina N. Masoud et al.   Acta Pharmaceutica Sinica B

A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance

(2015) Khushboo Irshad et al.   PLoS One

Overexpression of ERβ is sufficient to inhibit hypoxia-inducible factor-1 transactivation

(2014) Choa Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer

(2014) Martin Sjöström et al.   BREAST CANCER RESEARCH AND TREATMENT

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

GPER Mediates Activation of HIF1 /VEGF Signaling by Estrogens

(2014) E. M. De Francesco et al.   CANCER RESEARCH

Regulation of EMT by Notch Signaling Pathway in Tumor Progression

(2014) Yumei Li et al.   CURRENT CANCER DRUG TARGETS

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

GPER functions as a tumor suppressor in triple-negative breast cancer cells

(2014) Christine Weißenborn et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours

(2014) Cameron E. Snell et al.   PLoS One

TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity

(2014) Marina Stantic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells

(2014) Debangshu Samanta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

The role of reactive oxygen species and metabolism on cancer cells and their microenvironment

(2014) Ana Costa et al.   SEMINARS IN CANCER BIOLOGY

NOTCH Decoys That Selectively Block DLL/NOTCH or JAG/NOTCH Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

(2014) Thaned Kangsamaksin et al.   Cancer Discovery

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

(2014) Jennifer C. Villa et al.   Cell Reports

GPER Function in Breast Cancer: An Overview

(2014) Rosamaria Lappano et al.   Frontiers in Endocrinology

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer

(2013) Giovanni Roti et al.   CANCER CELL

Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

(2013) Shun-Pei Hung et al.   CELL TRANSPLANTATION

Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

(2013) A. F. Schott et al.   CLINICAL CANCER RESEARCH

Role of hypoxia-inducible factors in breast cancer metastasis

(2013) Daniele M Gilkes et al.   Future Oncology

GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs)

(2013) Marco Pupo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Ubiquitinations in the Notch Signaling Pathway

(2013) Julien Moretti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dll4-Notch signaling in regulation of tumor angiogenesis

(2013) Zhaoguo Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tumour oxygenation: implications for breast cancer prognosis

(2013) H. Rundqvist et al.   JOURNAL OF INTERNAL MEDICINE

17β-Estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1

(2013) Qi-Feng Jiang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The nuclear localization signal is required for nuclear GPER translocation and function in breast Cancer-Associated Fibroblasts (CAFs)

(2013) Marco Pupo et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling

(2013) Francis Kobia et al.   Molecular Oncology

Small molecules intercept Notch signaling and the early secretory pathway

(2013) Andreas Krämer et al.   Nature Chemical Biology

Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer

(2013) W Kong et al.   ONCOGENE

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling induces EMT in OSCC cell lines in a hypoxic environment

(2013) TAKAYUKI ISHIDA et al.   Oncology Letters

Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models

(2013) Cathy C. Zhang et al.   Stem Cells Translational Medicine

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness

(2012) Bin Bao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Stromal cells in tumor microenvironment and breast cancer

(2012) Yan Mao et al.   CANCER AND METASTASIS REVIEWS

Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness

(2012) Giuseppina Comito et al.   CANCER LETTERS

Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-  Status

(2012) H. Harrison et al.   CANCER RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Metabolic reprogramming and two-compartment tumor metabolism

(2012) Barbara Chiavarina et al.   CELL CYCLE

Notch signaling mediates TGF-β1-induced epithelial–mesenchymal transition through the induction of Snai1

(2012) Yosuke Matsuno et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Knockdown of prolyl-4-hydroxylase domain 2 inhibits tumor growth of human breast cancer MDA-MB-231 cells by affecting TGF-β1 processing

(2012) Marieke Wottawa et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of CXCR4 gene expression in breast cancer cells under diverse stress conditions

(2012) KLEOPATRA ANDREOU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition

(2012) Colleen S. Curran et al.   MATRIX BIOLOGY

Hypoxia and estrogen are functionally equivalent in breast cancer-endothelial cell interdependence

(2012) Andrea L George et al.   Molecular Cancer

MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo

(2012) D. W. Jenkins et al.   MOLECULAR CANCER THERAPEUTICS

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Endocytic routes to Notch activation

(2012) Martin Baron   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells

(2011) Kwanghee Ryu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rapid non-genomic signalling by 17β-oestradiol through c-Src involves mTOR-dependent expression of HIF-1α in breast cancer cells

(2011) S Sudhagar et al.   BRITISH JOURNAL OF CANCER

Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence

(2011) K Pandya et al.   BRITISH JOURNAL OF CANCER

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

(2011) Paolo Cirri et al.   CANCER AND METASTASIS REVIEWS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

Notch regulation of tumor angiogenesis

(2011) Esther Bridges et al.   Future Oncology

The G Protein-coupled Receptor 30 Is Up-regulated by Hypoxia-inducible Factor-1α (HIF-1α) in Breast Cancer Cells and Cardiomyocytes

(2011) Anna Grazia Recchia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition

(2011) Min-Zu Wu et al.   MOLECULAR CELL

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

(2011) J. M. Haughian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

(2011) Jan Theys et al.   RADIOTHERAPY AND ONCOLOGY

Interaction Between Notch and Hif-  in Development and Survival of Drosophila Blood Cells

(2011) T. Mukherjee et al.   SCIENCE

TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer

(2011) S. Stinson et al.   Science Signaling

Relationships between hypoxia markers and the leptin system, estrogen receptors in human primary and metastatic breast cancer: effects of preoperative chemotherapy

(2010) Mariusz Koda et al.   BMC CANCER

Nuclear Alternate Estrogen Receptor GPR30 Mediates 17 -Estradiol-Induced Gene Expression and Migration in Breast Cancer-Associated Fibroblasts

(2010) A. Madeo et al.   CANCER RESEARCH

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: Evidence for stromal-epithelial metabolic coupling

(2010) Gemma Migneco et al.   CELL CYCLE

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1

(2010) Yiwei Lin et al.   EMBO JOURNAL

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

(2010) Kohei Yamamizu et al.   JOURNAL OF CELL BIOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

HEXIM1 modulates vascular endothelial growth factor expression and function in breast epithelial cells and mammary gland

(2010) N Ogba et al.   ONCOGENE

The Role of the Microenvironment in Mammary Gland Development and Cancer

(2010) K. Polyak et al.   Cold Spring Harbor Perspectives in Biology

The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation

(2010) Julien Moretti et al.   PLOS BIOLOGY

Dauricine inhibits insulin-like growth factor-I-induced hypoxia inducible factor 1α protein accumulation and vascular endothelial growth factor expression in human breast cancer cells

(2009) Xu-dong Tang et al.   ACTA PHARMACOLOGICA SINICA

Numb – From flies to humans

(2009) Benedict Yan   BRAIN & DEVELOPMENT

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

(2009) J Chen et al.   BRITISH JOURNAL OF CANCER

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

(2009) Deo Prakash Pandey et al.   EMBO JOURNAL

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

GPR30 predicts poor survival for ovarian cancer

(2009) Harriet O. Smith et al.   GYNECOLOGIC ONCOLOGY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Regulation of endocytosis via the oxygen-sensing pathway

(2009) Yi Wang et al.   NATURE MEDICINE

Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment

(2009) Lauren K. Dunn et al.   PLoS One

A Notch1 Ectodomain Construct Inhibits Endothelial Notch Signaling, Tumor Growth, and Angiogenesis

(2008) Y. Funahashi et al.   CANCER RESEARCH

Fibroblasts Isolated from Common Sites of Breast Cancer Metastasis Enhance Cancer Cell Growth Rates and Invasiveness in an Interleukin-6–Dependent Manner

(2008) Adam W. Studebaker et al.   CANCER RESEARCH

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

(2008) P. Rizzo et al.   CANCER RESEARCH

Transcriptional repression of c-Jun's E3 ubiquitin ligases contributes to c-Jun induction by UV

(2008) Shira Anzi et al.   CELLULAR SIGNALLING

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY

Polycomb Complex 2 Is Required for E-cadherin Repression by the Snail1 Transcription Factor

(2008) N. Herranz et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of oxygen availability in embryonic development and stem cell function

(2008) M. Celeste Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

(2008) Patricia Chastagner et al.   PLoS One

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA