Stromal cells in tumor microenvironment and breast cancer

Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors

(2015) Constantin Jotzu et al.   Analytical Cellular Pathology

Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials

(2013)   LANCET

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells

(2012) A. Tsuyada et al.   CANCER RESEARCH

A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis

(2012) Swarnali Acharyya et al.   CELL

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Cancer-Associated Fibroblasts Induce Matrix Metalloproteinase-Mediated Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cells

(2012) A.-C. Johansson et al.   MOLECULAR CANCER RESEARCH

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility

(2012) O Aprelikova et al.   ONCOGENE

p16INK4A Represses the paracrine tumor-promoting effects of breast stromal fibroblasts

(2012) M M Al-Ansari et al.   ONCOGENE

Downregulation of miR-92a Is Associated with Aggressive Breast Cancer Features and Increased Tumour Macrophage Infiltration

(2012) Sofie Nilsson et al.   PLoS One

Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change

(2012) Shiaw-Wei Tyan et al.   PLoS One

Unlike Pancreatic Cancer Cells Pancreatic Cancer Associated Fibroblasts Display Minimal Gene Induction after 5-Aza-2′-Deoxycytidine

(2012) Jun Yu et al.   PLoS One

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype

(2012) Claire M Robinson et al.   RESPIRATORY RESEARCH

The prognostic significance of tumor-associated stroma in invasive breast carcinoma

(2012) Soomin Ahn et al.   TUMOR BIOLOGY

Cancer-associated adipocytes promotes breast tumor radioresistance

(2011) Ludivine Bochet et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through β1 integrin

(2011) Osvaldo Pontiggia et al.   BREAST CANCER RESEARCH AND TREATMENT

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3

(2011) Jingqi Chen et al.   CANCER CELL

MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing

(2011) T. A. Farazi et al.   CANCER RESEARCH

Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

(2011) L. Martinet et al.   CANCER RESEARCH

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Molecular Pathways: Osteoclast-Dependent and Osteoclast-Independent Roles of the RANKL/RANK/OPG Pathway in Tumorigenesis and Metastasis

(2011) W. C. Dougall   CLINICAL CANCER RESEARCH

Epithelial-mesenchymal transition in breast cancer lines is mediated through PDGF-D released by tissue-resident stem cells

(2011) Eswaran Devarajan et al.   INTERNATIONAL JOURNAL OF CANCER

Role of cancer-associated fibroblasts in breast cancer development and prognosis

(2011) Abdelilah Aboussekhra   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

(2011) Damya Laoui et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Tumor-Infiltrating CD8+ Lymphocytes Predict Clinical Outcome in Breast Cancer

(2011) Sahar M.A. Mahmoud et al.   JOURNAL OF CLINICAL ONCOLOGY

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

Interleukin-8 derived from local tissue-resident stromal cells promotes tumor cell invasion

(2011) Gabriel Welte et al.   MOLECULAR CARCINOGENESIS

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling

(2011) Wei Tan et al.   NATURE

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

(2011) M Musumeci et al.   ONCOGENE

Leukocyte composition of human breast cancer

(2011) B. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

(2011) David G. DeNardo et al.   Cancer Discovery

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

(2010) Michael J. Campbell et al.   BREAST CANCER RESEARCH AND TREATMENT

Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma

(2010) J D Veltman et al.   BRITISH JOURNAL OF CANCER

Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 down-regulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy

(2010) Isabelle Mercier et al.   CANCER BIOLOGY & THERAPY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer

(2010) Roy-Akira Saito et al.   CANCER RESEARCH

Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness

(2010) E. Giannoni et al.   CANCER RESEARCH

The role of miR-31 and its target gene SATB2 in cancer-associated fibroblasts

(2010) Olga Aprelikova et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Depletion of Tumor-Associated Macrophages Enhances the Effect of Sorafenib in Metastatic Liver Cancer Models by Antimetastatic and Antiangiogenic Effects

(2010) W. Zhang et al.   CLINICAL CANCER RESEARCH

MicroRNA-21: From Cancer to Cardiovascular Disease

(2010) Virginija Jazbutyte et al.   CURRENT DRUG TARGETS

Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics

(2010) Rita A Mukhtar et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

MicroRNAs in embryonic stem cell function and fate

(2010) G. Tiscornia et al.   GENES & DEVELOPMENT

Effect of bisphosphonates on proliferation and viability of mouse bone marrow-derived macrophages

(2010) Marco G. Cecchini et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Specific protein and miRNA patterns characterise tumour-associated fibroblasts in bladder cancer

(2010) Astrid Enkelmann et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Epigenetic mechanisms regulating CYP19 transcription in human breast adipose fibroblasts

(2010) Kevin C. Knower et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer

(2010) Dimitrios Iliopoulos et al.   MOLECULAR CELL

Transient Tumor-Fibroblast Interactions Increase Tumor Cell Malignancy by a TGF-β Mediated Mechanism in a Mouse Xenograft Model of Breast Cancer

(2010) Christina H. Stuelten et al.   PLoS One

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion

(2009) Severin Pinilla et al.   CANCER LETTERS

Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution

(2009) I. Campbell et al.   CANCER RESEARCH

Tissue-resident stem cells promote breast cancer growth and metastasis

(2009) Fabian L. Muehlberg et al.   CARCINOGENESIS

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Fibroblast Growth Factor Receptor 2-Positive Fibroblasts Provide a Suitable Microenvironment for Tumor Development and Progression in Esophageal Carcinoma

(2009) C. Zhang et al.   CLINICAL CANCER RESEARCH

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

(2009) Marta Coscia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Periprostatic Adipose Tissue as a Modulator of Prostate Cancer Aggressiveness

(2009) David S. Finley et al.   JOURNAL OF UROLOGY

Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts

(2009) C. L. Roland et al.   MOLECULAR CANCER THERAPEUTICS

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

(2009) Pierre Farmer et al.   NATURE MEDICINE

MicroRNAs: key regulators of stem cells

(2009) Vamsi K. Gangaraju et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

(2009) M Walter et al.   ONCOGENE

Mesenchymal Stem Cell Transition to Tumor-Associated Fibroblasts Contributes to Fibrovascular Network Expansion and Tumor Progression

(2009) Erika L. Spaeth et al.   PLoS One

Role of COX-2 in epithelial-stromal cell interactions and progression of ductal carcinoma in situ of the breast

(2009) M. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung

(2009) R. E. Harris   INFLAMMOPHARMACOLOGY

High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1

(2008) Biyun Qian et al.   BREAST CANCER RESEARCH AND TREATMENT

Regulation of In Situ to Invasive Breast Carcinoma Transition

(2008) Min Hu et al.   CANCER CELL

Global Hypomethylation of Genomic DNA in Cancer-Associated Myofibroblasts

(2008) L. Jiang et al.   CANCER RESEARCH

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

(2008) Koji Hiraoka et al.   CANCER SCIENCE

MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination

(2008) F. Fazi et al.   CARDIOVASCULAR RESEARCH

Expression of p21waf1/Cip1 in stromal fibroblasts of primary breast tumors

(2008) G. Trimis et al.   HUMAN MOLECULAR GENETICS

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Mesenchymal Stem Cells Derived from Human Adipose Tissues Favor Tumor Cell Growth in vivo

(2008) Ji Min Yu et al.   STEM CELLS AND DEVELOPMENT