HIF-1 at the crossroads of hypoxia, inflammation, and cancer

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

Carbonic Anhydrase IX Promotes Myeloid-Derived Suppressor Cell Mobilization and Establishment of a Metastatic Niche by Stimulating G-CSF Production

(2015) S. C. Chafe et al.   CANCER RESEARCH

Increased drug resistance in breast cancer by tumor-associated macrophages through IL-10/STAT3/bcl-2 signaling pathway

(2015) Cuixia Yang et al.   MEDICAL ONCOLOGY

A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms

(2015) Monica Cojoc et al.   SEMINARS IN CANCER BIOLOGY

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression

(2014) Patrizia Sanità et al.   BMC CANCER

Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells

(2014) M Mancini et al.   BRITISH JOURNAL OF CANCER

Interleukin 6 augments lung cancer chemotherapeutic resistance via ataxia-telangiectasia mutated/NF-kappaB pathway activation

(2014) Hong Qiong Yan et al.   CANCER SCIENCE

Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer

(2014) Jessica E.S. Shay et al.   CARCINOGENESIS

Gemcitabine Resistance is Associated with Epithelial-Mesenchymal Transition and Induction of HIF-1α in Pancreatic Cancer Cells

(2014) Rui Wang et al.   CURRENT CANCER DRUG TARGETS

The dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial–mesenchymal transition induced by hypoxia and TGF-β1

(2014) Guanyu Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel inhibitors of signal transducer and activator of transcription 3 signaling pathway: an update on the recent patent literature

(2014) Antonio Lavecchia et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Mechanisms of tumor escape from immune system: Role of mesenchymal stromal cells

(2014) Alessandro Poggi et al.   IMMUNOLOGY LETTERS

Tumor heterogeneity and cancer stem cell paradigm: Updates in concept, controversies and clinical relevance

(2014) Anup Kumar Singh et al.   INTERNATIONAL JOURNAL OF CANCER

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia and Hypoxia-Inducible Factor-1  Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

(2014) J. Jantsch et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

(2014) B. B. Lao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

(2014) P. Chaturvedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A ROS/STAT3/HIF-1α signaling cascade mediates EGF-induced TWIST1 expression and prostate cancer cell invasion

(2014) Kyung Hwa Cho et al.   PROSTATE

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

(2014) Ubaldo E. Martinez-Outschoorn et al.   SEMINARS IN CANCER BIOLOGY

STAT3 inhibitor NSC74859 radiosensitizes esophageal cancer via the downregulation of HIF-1α

(2014) Chi Zhang et al.   TUMOR BIOLOGY

Influence of different hypoxia models on metastatic potential of SGC-7901 gastric cancer cells

(2014) Zhi-Feng Miao et al.   TUMOR BIOLOGY

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

The Role of Hypoxia-Inducible Factor in Wound Healing

(2014) Wan Xing Hong et al.   Advances in Wound Care

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Hypoxia Triggers Hedgehog-Mediated Tumor-Stromal Interactions in Pancreatic Cancer

(2013) T. R. Spivak-Kroizman et al.   CANCER RESEARCH

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B

(2013) Shinichiro Kato et al.   CANCER SCIENCE

HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression

(2013) B. Philip et al.   CARCINOGENESIS

Wnt/β-catenin signaling enhances hypoxia-induced epithelial–mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling

(2013) Qi Zhang et al.   CARCINOGENESIS

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

(2013) Tania Fiaschi et al.   CELL CYCLE

Targeting the HIF pathway in inflammation and immunity

(2013) Carsten C Scholz et al.   CURRENT OPINION IN PHARMACOLOGY

Hypoxia-Induced Snail Expression Through Transcriptional Regulation by HIF-1α in Pancreatic Cancer Cells

(2013) Guang-hui Zhu et al.   DIGESTIVE DISEASES AND SCIENCES

Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts

(2013) Shinichiro Miyazaki et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts

(2013) Daniele M. Gilkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells

(2013) Murielle Mimeault et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Procollagen Lysyl Hydroxylase 2 Is Essential for Hypoxia-Induced Breast Cancer Metastasis

(2013) Daniele M. Gilkes et al.   MOLECULAR CANCER RESEARCH

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells

(2013) M R Pawlus et al.   ONCOGENE

Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: Correlations with poor prognosis

(2013) Jiali Zhang et al.   ORAL ONCOLOGY

HIF-1α is upregulated in human mesenchymal stem cells

(2013) Sami Palomäki et al.   STEM CELLS

Pathogenic role of HIF-1α in prostate hyperplasia in the presence of chronic inflammation

(2012) Hye-Jin Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients

(2012) Catharina Medrek et al.   BMC CANCER

Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells

(2012) Yoshihide Shimojo et al.   CLINICAL & EXPERIMENTAL METASTASIS

Highlights on Molecular Mechanisms of MDSC-Mediated Immune Suppression: Paving the Way for New Working Hypotheses

(2012) Samantha Solito et al.   IMMUNOLOGICAL INVESTIGATIONS

Hypoxia-inducible factors as key regulators of tumor inflammation

(2012) Soulafa Mamlouk et al.   INTERNATIONAL JOURNAL OF CANCER

HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis

(2012) Masaaki Higashiyama et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis and metastasis

(2012) G L Semenza   ONCOGENE

Intermittent Hypoxia Regulates Stem-like Characteristics and Differentiation of Neuroblastoma Cells

(2012) Vasantha Kumar Bhaskara et al.   PLoS One

Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

(2012) Maura Calvani et al.   PLoS One

Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells

(2012) L. Schito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

(2012) S. J. Conley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic Inflammation in Cancer Development

(2012) Gabriele Multhoff et al.   Frontiers in Immunology

Prognostic significance of STAT3 expression and its correlation with chemoresistance of non-small cell lung cancer cells

(2011) Zhenjie Yin et al.   ACTA HISTOCHEMICA

Cancer Associated Fibroblasts Exploit Reactive Oxygen Species Through a Proinflammatory Signature Leading to Epithelial Mesenchymal Transition and Stemness

(2011) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

EMT and Oxidative Stress: A Bidirectional Interplay Affecting Tumor Malignancy

(2011) Elisa Giannoni et al.   ANTIOXIDANTS & REDOX SIGNALING

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

NFκB and HIF display synergistic behaviour during hypoxic inflammation

(2011) Ulrike Bruning et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

HIF-1α coordinates lymphangiogenesis during wound healing and in response to inflammation

(2011) Jamie C. Zampell et al.   FASEB JOURNAL

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Involvement of TNFα-induced TLR4–NF-κB and TLR4–HIF-1α feed-forward loops in the regulation of inflammatory responses in glioma

(2011) Richa Tewari et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs

(2011) H Zhang et al.   ONCOGENE

Nuclear Factor-κB–Dependent Epithelial to Mesenchymal Transition Induced by HIF-1α Activation in Pancreatic Cancer Cells under Hypoxic Conditions

(2011) Zhuo-Xin Cheng et al.   PLoS One

Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells

(2011) T. M. Yeung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells

(2010) Marzia B. Gariboldi et al.   BIOCHEMICAL PHARMACOLOGY

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions

(2010) S. B. Coffelt et al.   CANCER RESEARCH

Knockout of HIF-1  in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

(2010) C. Werno et al.   CARCINOGENESIS

Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death

(2010) A Garedew et al.   CELL DEATH AND DIFFERENTIATION

The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis

(2010) Kuppusamy Balamurugan et al.   EMBO JOURNAL

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

(2010) Cesar A. Corzo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms

(2010) Bryan L. Copple   LIVER INTERNATIONAL

Signal Transducer and Activator of Transcription-3, Inflammation, and Cancer

(2009) Bharat B. Aggarwal et al.   Annals of the New York Academy of Sciences

Overexpression of cyclooxygenase-2 in urothelial carcinoma in conjunction with tumor-associated-macrophage infiltration, hypoxia-inducible factor-1α expression, and tumor angiogenesis

(2009) WAN-TZU CHEN et al.   APMIS

The EGF/CSF-1 Paracrine Invasion Loop Can Be Triggered by Heregulin  1 and CXCL12

(2009) L. Hernandez et al.   CANCER RESEARCH

The Cooperative Induction of Hypoxia-Inducible Factor-1  and STAT3 during Hypoxia Induced an Impairment of Tumor Susceptibility to CTL-Mediated Cell Lysis

(2009) M. Z. Noman et al.   JOURNAL OF IMMUNOLOGY

HIF-1α Modulates Energy Metabolism in Cancer Cells by Inducing Over-Expression of Specific Glycolytic Isoforms

(2009) Alvaro Marin-Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner

(2008) Kenichiro Nishi et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

(2008) Rose Du et al.   CANCER CELL

Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells

(2008) Mei-Jen Chuang et al.   CANCER SCIENCE

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1

(2008) Marie-Pierre Simon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA