期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms19051296
关键词
connexins; gap junctions; transcription; translation; post-translational modifications; trafficking
资金
- Instituto de Salud Carlos III [CPII16/00042, PI13/00763, PI16/00772]
- European Regional Development Fund (ERDF)
- NIH [R01-HL137112, R01-AA025854, F31-HL139109]
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins. The connexin gene family is under extensive regulation at the transcriptional and post-transcriptional level, and undergoes numerous modifications at the protein level, including phosphorylation, which ultimately affects their trafficking, stability, and function. Here, we summarize these key regulatory events, with emphasis on how these affect connexin multifunctionality in health and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据