Article
Ophthalmology
Kulandaiappan Varadaraj, Paul G. FitzGerald, S. Sindhu Kumari
Summary: The loss of lens-specific beaded filament proteins CP49 and filensin results in decreased optical quality and the development of abnormal optical aberrations in the lens, which worsens with age, but does not affect the water channel function of AQP0.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Engineering, Chemical
Xuhui Hu, Xing Chen, Mattia Giagnorio, Chunhong Wu, Yunbai Luo, Claus Helix-Nielsen, Ping Yu, Wenjing Zhang
Summary: A new class of PVDF-based membranes suitable for membrane distillation was prepared via electrospinning. By tuning the solvent ratio and operating parameters, the classical fiber morphology of PVDF electrospun membranes was changed to generate a beaded structure. Increasing the bead density improved the water contact angle and reduced the membrane thickness, but decreased the membrane mechanical stability. Simultaneous deployment of 17 and 25 wt% of PVDF solutions in a double-needle electrospinning device enabled the fabrication of electrospun PVDF-beaded membranes with high hydrophobicity, low thickness, and good mechanical stability for membrane distillation.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Astronomy & Astrophysics
Xia Sun, Xiaoli Yan, Hongfei Liang, Zhike Xue, Jincheng Wang, Liheng Yang, Zhe Xu, Liping Yang, Yang Peng, Qiaoling Li, Zihan li, Xinsheng Zhang
Summary: In this study, observations from the New Vacuum Solar Telescope, the Solar Dynamics Observatory, and the Global Oscillation Network Group were used to investigate the formation process of a filament in NOAA active region 12765 from June 5 to 8, 2020. It was found that intermittent small-scale magnetic reconnection occurred at the northern part of the filament, showing characteristics of oscillatory reconnections. The reconnection process resulted in continuous material injections into the filament channel, with bidirectional inflow and outflow, current sheets, and bright cusp-shaped structures. The formation of the filament was attributed to direct material injection into the filament channel due to small-scale magnetic reconnections.
ASTROPHYSICAL JOURNAL
(2023)
Editorial Material
Biology
Pierre A. Coulombe
Summary: Mapping intermediate filaments in three dimensions reveals variations in their organization across different cell types.
Article
Biology
Florian Geisler, Sanne Remmelzwaal, Vera Jankowski, Ruben Schmidt, Mike Boxem, Rudolf E. Leube
Summary: Using Caenorhabditis elegans, researchers have identified the IF polypeptide IFB-2 as an efficient suppressor of structural and functional deficiencies in mutants that disrupt the organization of the intestinal IF cytoskeleton. This rescue capability is specific to IF isotypes and extends to mutants that disrupt the function of other cytoskeletal proteins. The findings provide strong evidence for the adverse consequences of deranged IF networks, with implications for diseases characterized by altered IF network organization.
Article
Cell Biology
Miguel Jarrin, Alexia A. Kalligeraki, Alice Uwineza, Chris S. Cawood, Adrian P. Brown, Edward N. Ward, Khoa Le, Stefanie Freitag-Pohl, Ehmke Pohl, Bence Kiss, Antal Tapodi, Roy A. Quinlan
Summary: Research has shown that the C-terminal sequences of BFSP1 protein have independent membrane binding properties, binding to cell membranes through an adjacent amphipathic helix. This conclusion is of great significance for understanding the function of BFSP1 protein.
Article
Nanoscience & Nanotechnology
Xia Lv, Siyuan Ding, Lu Huang, Xueqin Li, Jinli Zhang
Summary: This study synthesized beaded nanofillers ZIF-8@AC using an in-situ growth method and incorporated them into a Pebax matrix to fabricate MMMs for efficient CO2 separation. The ZIF-8@AC played a vital role in improving gas permeability and gas selectivity by constructing internal and external transport pathways. The CO2 separation performance of the MMMs was significantly enhanced, overcoming the trade-off effect and approaching the upper bound of 2019.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Xun-Cai Yang, Chun-Fang Hu, Peng-Li Zhang, Shuo Li, Chun-Sheng Hu, Rong-Xia Geng, Cheng-He Zhou
Summary: A novel type of coumarin thiazoles were synthesized and exhibited favorable inhibitory potency against various strains, especially methicillin-resistant Staphylococcus aureus (MRSA). The active compound showed low toxicity towards mammalian cells, effectively eradicated MRSA biofilms, and had a low probability of engendering drug resistance.
BIOORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Sherif A. Eldirany, Ivan B. Lomakin, Minh Ho, Christopher G. Bunick
Summary: Intermediate filaments are essential players in cellular processes, with their structural and biochemical properties playing crucial roles in filament assembly mechanisms and interactions with binding partners. Recent advances in understanding IF structure from studies on keratins, glial fibrillary acidic protein, and lamin have revealed new insights into assembly mechanisms, structural elements, and functional domains, enhancing our understanding of the connection between IF structure, pathogenic mutations, and clinical diseases in humans.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Biology
Irene Nagle, Florence Delort, Sylvie Henon, Claire Wilhelm, Sabrina Batonnet-Pichon, Myriam Reffay
Summary: The liquid and elastic behaviors of tissues play a crucial role in their morphology and response to the environment. In this study, we investigated the role of individual cell properties and intermediate filaments on the mechanics of tissue models, specifically focusing on mouse muscle precursor cells. We found that intermediate filaments, particularly desmin, play a significant role in the macroscopic mechanics of unorganized muscle tissue models, even at an early stage of differentiation.
Review
Biochemistry & Molecular Biology
Yamin Liang, Lu Li, Yanmei Chen, Shulei Zhang, Zhaozhi Li, Jinyan Xiao, Dangheng Wei
Summary: The cytoskeleton, mainly composed of intermediate filaments, actin, and microtubules, regulates the mechanical properties of cells. Vimentin, an intermediate filament protein, has both mechanical and nonmechanical functions in atherosclerosis progression.
DNA AND CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Davood Gheidari, Morteza Mehrdad, Saloomeh Maleki
Summary: Quinazoline-2,4(1H,3H)-dione is a major class of N-fused heterocyclic compound with diverse biological activities, and has attracted considerable attention in organic and medicinal chemistry. This paper provides an overview of the various manufacturing methods for biologically active compounds based on quinazoline-2,4(1H,3H)-dione and 2,4-dichloroquinazoline cores.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2022)
Review
Cell Biology
Pieter-Jan Vermeire, Giel Stalmans, Anastasia Lilina, Jan Fiala, Petr Novak, Harald Herrmann, Sergei Strelkov
Summary: IFs play a crucial role in normal cell physiology and are linked to numerous diseases, highlighting the importance of understanding their molecular structure. While progress has been made in studying the IF structure, many mysteries and challenges remain. In addition to X-ray crystallography, chemical cross-linking and cryoelectron microscopy are expected to lead to major advancements in the field in the near future.
Article
Biochemistry & Molecular Biology
Fangjin Lu, Lin Zhu, Bin Mu, Xiaoyu Jia, Jiao Wang, Ping Mu
Summary: The study revealed that DRR1 and Tmod2 play critical roles in axon formation during the early stage of hippocampal neuron development, with DRR1 knockdown leading to suppressed axon outgrowth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Keigo Murakami, Masashi Sato, Yoshiya Miyasaka, Kuniyuki Hatori
Summary: The distribution and interaction of the intermediate filament protein Desmin with phospholipids play a crucial role in cell functions, with the potential for association depending on Desmin form and lipid shape. The behavior and composition of living membranes may affect the distribution of Desmin networks, highlighting the importance of understanding lipid-Desmin interactions for cell regulation and integrity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Hematology
David S. Gokhin, Velia M. Fowler
CURRENT OPINION IN HEMATOLOGY
(2016)
Article
Microscopy
David S. Gokhin, Velia M. Fowler
JOURNAL OF MICROSCOPY
(2017)
Article
Multidisciplinary Sciences
Catherine Cheng, David S. Gokhin, Roberta B. Nowak, Velia M. Fowler
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2016)
Article
Ophthalmology
Catherine Cheng, Velia M. Fowler, Xiaohua Gong
EXPERIMENTAL EYE RESEARCH
(2017)
Article
Ophthalmology
Catherine Cheng, Roberta B. Nowak, Velia M. Fowler
EXPERIMENTAL EYE RESEARCH
(2017)
Article
Cell Biology
Zhenhua Sui, David S. Gokhin, Roberta B. Nowak, Xinhua Guo, Xiuli An, Velia M. Fowler
MOLECULAR BIOLOGY OF THE CELL
(2017)
Article
Multidisciplinary Sciences
Tongbin Wu, Yongxin Mu, Julius Bogomolovas, Xi Fang, Jennifer Veevers, Roberta B. Nowak, Christopher T. Pappas, Carol C. Gregorio, Sylvia M. Evans, Velia M. Fowler, Ju Chen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Cell Biology
Justin Parreno, Catherine Cheng, Roberta B. Nowak, Velia M. Fowler
MOLECULAR BIOLOGY OF THE CELL
(2018)
Article
Multidisciplinary Sciences
Quentin Bernard, Alexis A. Smith, Xiuli Yang, Juraj Koci, Shelby D. Foor, Sarah D. Cramer, Xuran Zhuang, Jennifer E. Dwyer, Yi-Pin Lin, Emmanuel F. Mongodin, Adriana Marques, John M. Leong, Juan Anguita, Utpal Pal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell Biology
Catherine Cheng, Roberta B. Nowak, Michael B. Amadeo, Sondip K. Biswas, Woo-Kuen Lo, Velia M. Fowler
JOURNAL OF CELL SCIENCE
(2018)
Article
Neurosciences
Omotola F. Omotade, Yanfang Rui, Wenliang Lei, Kuai Yu, H. Criss Hartzell, Velia M. Fowler, James Q. Zheng
JOURNAL OF NEUROSCIENCE
(2018)
Article
Ophthalmology
Yilin Zhao, Phillip A. Wilmarth, Catherine Cheng, Saima Limi, Velia M. Fowler, Deyou Zheng, Larry L. David, Ales Cvekl
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Hematology
Roberta B. Nowak, Julien Papoin, David S. Gokhin, Carla Casu, Stefano Rivella, Jeffrey M. Lipton, Lionel Blanc, Velia M. Fowler
Review
Biophysics
Velia M. Fowler, Roberto Dominguez
BIOPHYSICAL JOURNAL
(2017)
Article
Ophthalmology
Catherine Cheng, Roberta B. Nowak, Sondip K. Biswas, Woo-Kuen Lo, Paul G. FitzGerald, Velia M. Fowler
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2016)