Article
Biochemistry & Molecular Biology
Marcel Doerflinger, Boris Reljic, Joseph Menassa, Christina Nedeva, Irvin Jose, Pierre Faou, Liana Mackiewicz, Ashley Mansell, Marc Pellegrini, Richard Hotchkiss, Hamsa Puthalakath
Summary: Sepsis-induced lymphopenia and immune suppression are crucial for patient survival, yet accurate prognostic techniques or biomarkers for cell death are lacking. The novel circulating prognostic biomarker BiP may serve as a valuable tool for monitoring immune cell death during sepsis.
Article
Plant Sciences
Gan Ai, Hai Zhu, Xiaowei Fu, Jin Liu, Tianli Li, Yang Cheng, Yang Zhou, Kun Yang, Weiye Pan, Huanxin Zhang, Zishan Wu, Saiyu Dong, Yeqiang Xia, Yuanchao Wang, Ai Xia, Yiming Wang, Daolong Dou, Maofeng Jing
Summary: Recent studies have shown that plants activate endoplasmic reticulum stress-mediated immunity (ERSI) in response to pathogen infection, with the regulator NAC089 playing a crucial role in this process. NAC089 translocates from the endoplasmic reticulum to the nucleus via the Golgi apparatus, contributing positively to plant resistance against pathogens.
Article
Chemistry, Multidisciplinary
Tae Woo Kim
Summary: CA induces cell death in gastric cancer cells through ER stress and Ca2+ release, and inhibiting ER stress can mitigate the cytotoxicity of CA. CA also triggers autophagic cell death by inhibiting G9a and activating LC3B.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Po-Han Chen, Jianli Wu, Yitong Xu, Chien-Kuang Cornelia Ding, Alexander A. Mestre, Chao-Chieh Lin, Wen-Hsuan Yang, Jen-Tsan Chi
Summary: The study revealed that zinc is essential for ferroptosis in breast and renal cancer cells. The genetic determinant ZIP7 controls zinc transport and plays a crucial role in ferroptosis. Inhibition of ZIP7 can protect cells against ferroptosis, highlighting a potential therapeutic target for diseases involving ferroptosis and zinc dysregulation.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Feixiang Ding, Fei Li, Dongsheng Tang, Bin Wang, Junyan Liu, Xiaoyuan Mao, Jiye Yin, Haihua Xiao, Jing Wang, Zhaoqian Liu
Summary: Recent progress in studying copper-dependent targets and pathways in tumor treatment has provided new insights into leveraging copper-dependent disease vulnerabilities and manipulation of intratumor copper transportation. Researchers developed ROS-sensitive nanoparticles loaded with copper chaperone inhibitor DC_AC50 and cisplatin(IV) prodrug, which enhanced the chemotherapeutic effect of cisplatin, induced significant ROS generation, and facilitated immunogenic cell death (ICD) for sustained immune response.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Environmental Sciences
Sang-Hun Kim, Seon-Hee Oh
Summary: We investigated the molecular mechanisms of BNIP3L/Nix and SQSTM1/p62 in sodium arsenite (NaAR)-induced cytotoxicity. The morphology and adhesion of H460 cells showed noticeable changes with different NaAR concentrations. NaAR exposure resulted in DNA damage-mediated apoptosis and Nix accumulation via proteasome inhibition. Nix affected the endoplasmic reticulum (ER) and induced ER stress responses. The expressions of p62 and Nix were inversely correlated and colocalized. Autophagy inhibition upregulated the expressions of Nix, p62, cell cycle progression gene 1 (CCPG1), heme oxygenase (HO)-1, and calnexin. Knockdown of Nix reduced NaAR-induced ER stress and microtubule-associated protein 1 A/1B light-chain 3 (LC3) B-II levels, and increased CCPG1 and calnexin levels. Knockdown of p62 upregulated Nix, LC3-II, CCPG1 expressions, and ER stress responses, indicating that p62 regulates Nix levels. The downstream pathways of Nix were mitigated by Ca2+ chelators. We demonstrated the critical roles of Nix and p62 in ER stress and ER-phagy in response to NaAR.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sheng-Yao Peng, Jen-Yang Tang, Ting-Hsun Lan, Jun-Ping Shiau, Kuan-Liang Chen, Jiiang-Huei Jeng, Ching-Yu Yen, Hsueh-Wei Chang
Summary: Manoalide preferentially inhibits the proliferation of oral cancer cells by modulating reactive oxygen species (ROS) and apoptosis without cytotoxicity to normal cells. This study reveals that the induction of endoplasmic reticulum (ER) stress contributes to the antiproliferative and apoptotic effects of Manoalide in oral cancer. Manoalide induces ER expansion and aggresome accumulation in oral cancer cells and differentially affects the mRNA and protein expressions of ER-stress-associated genes compared to normal cells. Moreover, ER stress inducer enhances the antiproliferative, caspase 3/7 activation, and autophagy effects of Manoalide on oral cancer cells, while ROS inhibitor reverses the ER stress response and aggresome formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Min Jeong Kim, Jin Mo Ku, Se Hyang Hong, Hyo In Kim, Yun Young Kwon, Joon-Sang Park, Deok Hyun Jung, Yong Cheol Shin, Seong-Gyu Ko
Summary: Prostate cancer is the second most diagnosed cancer in American men, with chemotherapy being a common treatment method. However, the study focused on investigating the molecular mechanism of JI017 in human prostate cancer cells, revealing its induction of apoptosis through the ER stress pathway. Various experiments were conducted to demonstrate that JI017 inhibits prostate cancer cell proliferation via ROS-mediated ER stress pathway and induces cell death.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liam Baird, Masayuki Yamamoto
Summary: In human cancer, abnormal activation of the NRF2 pathway can allow cancer cells to evade immune surveillance and develop into malignant tumors by reducing antigen presentation and activating signals for NK cells, which inhibits the involvement of immune effector cells.
Article
Biochemistry & Molecular Biology
Caijun Zhao, Duo Yu, Zhaoqi He, Lijuan Bao, Lianjun Feng, Luotong Chen, Zhuoyu Liu, Xiaoyu Hu, Naisheng Zhang, Tiejun Wang, Yunhe Fu
Summary: Acute cadmium exposure can induce renal injury through ferroptosis, regulated by factors such as ER stress, autophagy, and ferritinophagy. Iron dysregulation and MitoROS activation are also involved in the process.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
M. R. Preetha Rani, P. Salin Raj, Anupama Nair, S. Ranjith, K. Rajankutty, K. G. Raghu
Summary: This study investigated the role of endoplasmic reticulum stress and its related pathways in diabetic cardiomyopathy, and found that endoplasmic reticulum stress plays a crucial role in the progression of the disease. Furthermore, chlorogenic acid was found to be beneficial against the pathological alterations caused by high glucose.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Virology
Florian Hinte, Jendrik Mueller, Wolfram Brune
Summary: The Unfolded Protein Response (UPR) and Endoplasmic Reticulum-Associated Degradation (ERAD) play crucial roles in protein quality control in the secretory pathway. Viruses like cytomegaloviruses modulate the UPR to benefit their replication by degrading IRE1, a sensor molecule for UPR. The viral M50 protein degrades IRE1 using the ERAD machinery, facilitating virus replication.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Swetha Medchalmi, Priyanka Tare, Zuberwasim Sayyad, Ghanshyam Swarup
Summary: Mutations in OPTN, such as the 2-bp insertion, can lead to aberrant protein sequences, causing diseases like glaucoma and ALS. This mutation induces cell death, localizes mainly in the nucleus, and activates ER stress through Tbk1.
Article
Plant Sciences
Jiaqi Sun, Weina Wang, Huanquan Zheng
Summary: This study reveals the involvement of RHD3 in the ER-phagy process under ER stress and the hyposensitivity of the rhd3 mutant to ER and salt stress. The increased association of RHD3 with ATG8e-marked autophagosomes and its breakdown under ER stress are demonstrated. The physical interaction between RHD3 and ATG8 is also enhanced under ER stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Rashedul Alam, Mohammad Fazlul Kabir, Hyung-Ryong Kim, Han-Jung Chae
Summary: Cancer cells adapt autophagy as a protective mechanism to counter stress, but the role of autophagy in tumorigenesis and drug resistance is complex and controversial. Accelerated autophagy poses a challenge for anticancer therapy, and addressing noncanonical ER stress or UPR components is an effective approach to suppress cytoprotective autophagy.
Article
Biochemical Research Methods
Lenka Strbkova, Daniel Zicha, Pavel Vesely, Radim Chmelik
JOURNAL OF BIOMEDICAL OPTICS
(2017)
Letter
Dermatology
Thiviyani Maruthappu, Lisa A. McGinty, Diana C. Blaydon, Benjamin Fell, Arlo Maatta, Rebecca Duit, Tim Hawkins, Kristin M. Braun, Michael A. Simpson, Edel A. O'Toole, David P. Kelsell
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Multidisciplinary Sciences
Paola Arcidiacono, Catherine M. Webb, Matthew A. Brooke, Huiqing Zhou, Paul J. Delaney, Keat-Eng Ng, Diana C. Blaydon, Andrew Tinker, David P. Kelsell, Anissa Chikh
NATURE COMMUNICATIONS
(2018)
Article
Dermatology
Renan Tironi G. de Oliveira, Denise Maria Christofolini, Paulo R. Criado, Eduardo Lacaz Martins, David Kelsell, Carlos D'Apparecida Santos Machado Filho
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2020)
Article
Medicine, Research & Experimental
Florence Enjalbert, Priya Dewan, Matthew P. Caley, Eleri M. Jones, Mary A. Morse, David P. Kelsell, Anton J. Enright, Edel A. O'Toole
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Editorial Material
Dermatology
Christopher E. M. Griffiths, Marta Szell, David P. Kelsell
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Editorial Material
Dermatology
Sirkku Peltonen, Sabine A. Eming, Christopher E. M. Griffiths, Marta Szell, David Kelsell, Menno Alexander De Rie
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Dermatology
Jennifer Chao-Chu, Stephen Murtough, Najwa Zaman, Daniel J. Pennington, Diana C. Blaydon, David P. Kelsell
Summary: The palmoplantar epidermis is a specialized region of skin subjected to high mechanical stress, with mutations linked to palmoplantar keratinization and esophageal cancer syndrome potentially affecting stress pathways. iRhom2 plays a crucial role in regulating skin thickness, stress response, and antiviral pathways.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Hematology
Vaclav Seda, Eva Vojackova, Laura Ondrisova, Lenka Kostalova, Sonali Sharma, Tomas Loja, Gabriela Mladonicka Pavlasova, Daniel Zicha, Marie Kudlickova Peskova, Jan Krivanek, Kvetoslava Liskova, Leos Kren, Vladimir Benes, Katerina Musilova Litzmanova, Marek Borsky, Jan Oppelt, Jan Verner, Sarka Pospisilova, Yvona Brychtova, Anna Panovska, Zhi Tan, Shuxing Zhang, Michael Doubek, Katerina Amruz Cerna, Jiri Mayer, Marek Mraz
Summary: The migration and survival of CLL cells are influenced by GAB1, which can be targeted for therapeutic purposes, especially in combination with BTK inhibitors.
Article
Dermatology
Soha S. Tawfik, Bjorn R. Thomas, David P. Kelsell, Jonathan Grigg, Edel A. O'Toole
Summary: This study examines the impact of atopic eczema on the quality of life of Bangladeshi children and young adults, and finds that factors such as disease severity, distribution, family dynamics, and socioeconomic status influence the quality of life of patients.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Biographical-Item
Cell Biology
Klaus Unsicker, Brigitte M. Jockusch, David P. Kelsell
CELL AND TISSUE RESEARCH
(2022)
Article
Materials Science, Biomaterials
Petr Lepcio, Juraj Svatik, Ema Reznakova, Daniel Zicha, Alan J. Lesser, Frantisek Ondreas
Summary: Bones are an excellent biomaterial with high mechanical stiffness and the ability to deliver nutrition. 3D printing allows for precise shape control, but the current resolution limits and the inability to fabricate larger objects hinder its application in bone reproduction. This study presents a unique method using a biocompatible polymer to create hierarchically aligned microporous canals. The fine dimensions of these canals combined with other properties have promising potential for various applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Daniel Zicha
Summary: The incidence of cancer-caused deaths is increasing globally, mainly due to invasion and metastasis of cancer cells. Metastasis suppressor protein 4.1B has been identified as a potential target for inhibiting cancer metastasis by affecting cell motility. This discovery suggests that quantitative phase imaging with incoherent light could be a valuable tool for testing cancer cell motility and growth, with implications for personalized cancer treatment.
SCIENTIFIC REPORTS
(2022)
Proceedings Paper
Engineering, Biomedical
Marketa Suranova, Daniel Zicha, Pavel Vesely, Jan Brabek, Veronika Juzova, Radim Chmelik
Summary: The study exposed live lung cancer cells to selected medications with anti-metastatic potential in vitro, and used time-lapse hiQPI to accurately measure the effects on cell growth and motility.
EMERGING TECHNOLOGIES FOR CELL AND TISSUE CHARACTERIZATION
(2021)
Letter
Dermatology
S. C. I. Ip, D. L. Cottle, L. K. Jones, J. M. Weir, D. P. Kelsell, E. A. O'Toole, P. J. Meikle, I. M. Smyth
BRITISH JOURNAL OF DERMATOLOGY
(2017)