mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics

(2016) Brett D. McKinnon et al.   HUMAN REPRODUCTION UPDATE

Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise

(2016) Reza Soleimani et al.   Aging-US

New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators

(2015) Xinhui Sun et al.   CELL CYCLE

Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency

(2015) Nao Suzuki et al.   HUMAN REPRODUCTION

Rictor/mTORC2 Pathway in Oocytes Regulates Folliculogenesis, and Its Inactivation Causes Premature Ovarian Failure

(2015) Zhenguo Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for prolonged and unique amenorrhea-related symptoms in women with premature ovarian failure/primary ovarian insufficiency

(2015) Amanda A. Allshouse et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Loss of Tuberous Sclerosis Complex 2 (TSC2) Is Frequent in Hepatocellular Carcinoma and Predicts Response to mTORC1 Inhibitor Everolimus

(2015) H. Huynh et al.   MOLECULAR CANCER THERAPEUTICS

Goserelin for Ovarian Protection during Breast-Cancer Adjuvant Chemotherapy

(2015) Halle C.F. Moore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice

(2015) Eun Mi Chang et al.   PLoS One

Somatic Cells Initiate Primordial Follicle Activation and Govern the Development of Dormant Oocytes in Mice

(2014) Hua Zhang et al.   CURRENT BIOLOGY

Ovarian tissue cryopreservation: a committee opinion

(2014)   FERTILITY AND STERILITY

Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas

(2014) Michio Kitajima et al.   FERTILITY AND STERILITY

The physiology and clinical utility of anti-Müllerian hormone in women

(2014) Didier Dewailly et al.   HUMAN REPRODUCTION UPDATE

Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset

(2014) Suzette Tardif et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Committee Opinion No. 589

(2014)   OBSTETRICS AND GYNECOLOGY

Endometrial CXCL13 Expression Is Cycle Regulated in Humans and Aberrantly Expressed in Humans and Rhesus Macaques With Endometriosis

(2014) Jason M. Franasiak et al.   Reproductive Sciences

Caloric Restriction Promotes the Reserve of Follicle Pool in Adult Female Rats by Inhibiting the Activation of Mammalian Target of Rapamycin Signaling

(2014) Li Li et al.   Reproductive Sciences

SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

(2014) Xiao-Ling Zhou et al.   Journal of Ovarian Research

Concurrent treatment with gonadotropin-releasing hormone agonists for chemotherapy-induced ovarian damage in premenopausal women with breast cancer: A meta-analysis of randomized controlled trials

(2013) Bo Yang et al.   BREAST

Everolimus: side effect profile and management of toxicities in breast cancer

(2013) Elisavet Paplomata et al.   BREAST CANCER RESEARCH AND TREATMENT

Obesity and poor reproductive outcome: female and male body weight matter

(2013) José Bellver   FERTILITY AND STERILITY

Obesity accelerates ovarian follicle development and follicle loss in rats

(2013) Na Wang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dual Inhibition of PI3K and mTOR Signaling Pathways Decreases Human Pancreatic Neuroendocrine Tumor Metastatic Progression

(2013) Clarisse Djukom et al.   PANCREAS

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

(2013) K. Kawamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclophosphamide Triggers Follicle Activation and "Burnout"; AS101 Prevents Follicle Loss and Preserves Fertility

(2013) L. Kalich-Philosoph et al.   Science Translational Medicine

Investigational drug MLN0128, a novel TORC1/2 inhibitor, demonstrates potent oral antitumor activity in human breast cancer xenograft models

(2012) Yesim Gökmen-Polar et al.   BREAST CANCER RESEARCH AND TREATMENT

Sirolimus-Associated Testicular Toxicity

(2012) Jordi Rovira et al.   TRANSPLANTATION

Why do people postpone parenthood? Reasons and social policy incentives

(2011) Melinda Mills et al.   HUMAN REPRODUCTION UPDATE

Effect of Obesity on Oocyte and Embryo Quality in Women Undergoing In Vitro Fertilization

(2011) Divya K. Shah et al.   OBSTETRICS AND GYNECOLOGY

From Victim to Survivor to Thriver: Helping Women with Primary Ovarian Insufficiency Integrate Recovery, Self-Management, and Wellness

(2011) Evelina Sterling et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Toxicity of Chemotherapy and Radiation on Female Reproduction

(2010) DROR MEIROW et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

Correlation of ovarian reserve tests with histologically determined primordial follicle number

(2010) Karl R. Hansen et al.   FERTILITY AND STERILITY

Primary ovarian insufficiency

(2010) Michel De Vos et al.   LANCET

Activation of dormant ovarian follicles to generate mature eggs

(2010) J. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

(2009) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

Gonadal dysfunction and infertility in kidney transplant patients receiving sirolimus

(2009) Yousef Boobes et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles

(2009) D. Adhikari et al.   MOLECULAR HUMAN REPRODUCTION

Oocyte-Specific Deletion of Pten Causes Premature Activation of the Primordial Follicle Pool

(2008) P. Reddy et al.   SCIENCE