Flagellin as a vaccine adjuvant

Fusion proteins of flagellin and the major birch pollen allergen Bet v 1 show enhanced immunogenicity, reduced allergenicity, and intrinsic adjuvanticity

(2018) Claudia Kitzmüller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hepatitis B core antigen based novel vaccine against porcine epidemic diarrhea virus

(2018) Frank Gillam et al.   JOURNAL OF VIROLOGICAL METHODS

Vaccination with self-adjuvanted protein nanoparticles provides protection against lethal influenza challenge

(2017) Christopher P. Karch et al.   Nanomedicine-Nanotechnology Biology and Medicine

Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages

(2017) Elisabeth Müller et al.   Frontiers in Immunology

Immunogenicity of Pseudomonas aeruginosa recombinant b-type fagellin as a vaccine candidate: Protective efficacy in a murine burn wound sepsis model

(2016) Bahador Behrouz et al.   BURNS

Yellow fever vaccine: worthy friend or stealthy foe?

(2016) Stephen J. Seligman et al.   Expert Review of Vaccines

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models

(2016) Alice Halliday et al.   Parasites & Vectors

Immunity Elicited by an Experimental Vaccine Based on Recombinant Flagellin-Porcine Circovirus Type 2 Cap Fusion Protein in Piglets

(2016) Shanshan Zhu et al.   PLoS One

Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS

(2016) Jesse D. Deere et al.   PLoS One

Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity

(2016) Kuo-Hsing Lin et al.   Scientific Reports

Phase 1 Safety and Immunogenicity Study of a Quadrivalent Seasonal Flu Vaccine Comprising Recombinant Hemagglutinin-Flagellin Fusion Proteins

(2016) Lynda Tussey et al.   Open Forum Infectious Diseases

An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium flagellin

(2015) Li Song et al.   BMC BIOTECHNOLOGY

TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity

(2015) D. Geng et al.   CANCER RESEARCH

Adjuvant for vaccine immunotherapy of cancer - focusing on Toll-like receptor 2 and 3 agonists for safely enhancing antitumor immunity

(2015) Tsukasa Seya et al.   CANCER SCIENCE

Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs

(2015) Nikolai Petrovsky   DRUG SAFETY

Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production

(2015) Adriana Flores-Langarica et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Biosynthetically engineered lipopolysaccharide as vaccine adjuvant

(2015) Afshin Zariri et al.   Expert Review of Vaccines

Safety and immunogenicity of a live attenuated Japanese encephalitis chimeric virus vaccine (IMOJEV®) in children

(2015) K Chokephaibulkit et al.   Expert Review of Vaccines

Pseudomonas aeruginosa flagellin as an adjuvant: superiority of a conjugated form of flagellin versus a mixture with a human immunodeficiency virus type 1 vaccine candidate in the induction of immune responses

(2015) Safura Delavari et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Recombinant Flagellin-Porcine Circovirus Type 2 Cap Fusion Protein Promotes Protective Immune Responses in Mice

(2015) Chunyan Zhang et al.   PLoS One

Use of recombinant flagellin in oil-in-water emulsions enhances hemagglutinin-specific mucosal IgA production and IL-17 secreting T cells against H5N1 avian influenza virus infection

(2015) Chih-Hsuan Lai et al.   VACCINE

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer

(2015) Shee Eun Lee et al.   OncoImmunology

Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice

(2014) Yang Xiao et al.   Cellular & Molecular Immunology

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity

(2014) Bao-Zhong Wang et al.   JOURNAL OF CONTROLLED RELEASE

Flagellin Treatment Protects against Chemicals, Bacteria, Viruses, and Radiation

(2014) M. Vijay-Kumar et al.   JOURNAL OF IMMUNOLOGY

A Dual TLR Agonist Adjuvant Enhances the Immunogenicity and Protective Efficacy of the Tuberculosis Vaccine Antigen ID93

(2014) Mark T. Orr et al.   PLoS One

Prevention of Intestinal Allergy in Mice by rflaA:Ova Is Associated with Enforced Antigen Processing and TLR5-Dependent IL-10 Secretion by mDC

(2014) Stefan Schülke et al.   PLoS One

Low doses of flagellin-L2 multimer vaccines protect against challenge with diverse papillomavirus genotypes

(2014) Kirill Kalnin et al.   VACCINE

Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

(2014) Julia Scheiermann et al.   VACCINE

An Eimeria vaccine candidate based on Eimeria tenella immune mapped protein 1 and the TLR-5 agonist Salmonella typhimurium FliC flagellin

(2013) Guangwen Yin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modern Subunit Vaccines: Development, Components, and Research Opportunities

(2013) Peter Michael Moyle et al.   ChemMedChem

Immunogenicity of Recombinant Proteins Consisting of Plasmodium vivax Circumsporozoite Protein Allelic Variant-Derived Epitopes Fused with Salmonella enterica Serovar Typhimurium Flagellin

(2013) Monica Teixeira Andrade Leal et al.   Clinical and Vaccine Immunology

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

(2013) Youssef Aachoui et al.   CURRENT OPINION IN MICROBIOLOGY

Combination of adjuvants: the future of vaccine design

(2013) Adele Mount et al.   Expert Review of Vaccines

Protective Humoral Immunity Elicited by a Needle-Free Malaria Vaccine Comprised of a Chimeric Plasmodium falciparum Circumsporozoite Protein and a Toll-Like Receptor 5 Agonist, Flagellin

(2013) Daniel Carapau et al.   INFECTION AND IMMUNITY

Signaling Pathways in Murine Dendritic Cells That Regulate the Response to Vesicular Stomatitis Virus Vectors That Express Flagellin

(2013) J. R. Smedberg et al.   JOURNAL OF VIROLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Recombinant Rabies Viruses Expressing GM-CSF or Flagellin Are Effective Vaccines for Both Intramuscular and Oral Immunizations

(2013) Ming Zhou et al.   PLoS One

The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

(2013) Maria L. Knudsen et al.   PLoS One

Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist

(2013) L. G. Burdelya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen

(2013) Irshad A. Hajam et al.   RESEARCH IN VETERINARY SCIENCE

Vaccination with recombinant FimH fused with flagellin enhances cellular and humoral immunity against urinary tract infection in mice

(2013) Mohammad Reza Asadi Karam et al.   VACCINE

Flagellin enhances tumor-specific CD8+ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model

(2013) Chung Truong Nguyen et al.   VACCINE

Construction and Immunological Evaluation of Dual Cell Surface Display of HIV-1 Gag and Salmonella enterica Serovar Typhimurium FliC in Lactobacillus acidophilus for Vaccine Delivery

(2012) Akinobu Kajikawa et al.   Clinical and Vaccine Immunology

Structural Basis of TLR5-Flagellin Recognition and Signaling

(2012) S.-i. Yoon et al.   SCIENCE

Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses

(2012) J. Garaude et al.   Science Translational Medicine

Development of VAX128, a recombinant hemagglutinin (HA) influenza-flagellin fusion vaccine with improved safety and immune response

(2012) David N. Taylor et al.   VACCINE

Activation of Toll-like Receptor 5 on Breast Cancer Cells by Flagellin Suppresses Cell Proliferation and Tumor Growth

(2011) Z. Cai et al.   CANCER RESEARCH

Chimeric flagellin expressed by Salmonella typhimurium induces an ESAT-6-specific Th1-type immune response and CTL effects following intranasal immunization

(2011) Hui Zhang et al.   Cellular & Molecular Immunology

Viral vectors as vaccine platforms: deployment in sight

(2011) Christine S Rollier et al.   CURRENT OPINION IN IMMUNOLOGY

Induction of anti-tumor immunity and T-cell responses using nanodelivery systems engrafting TLR-5 ligand

(2011) Amulya K Panda   Expert Review of Vaccines

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Recombinant Vesicular Stomatitis Virus–Based Vaccines Against Ebola and Marburg Virus Infections

(2011) Thomas W. Geisbert et al.   JOURNAL OF INFECTIOUS DISEASES

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Innate immunity and adjuvants

(2011) S. Akira   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immunogenicity and Efficacy of Flagellin-Fused Vaccine Candidates Targeting 2009 Pandemic H1N1 Influenza in Mice

(2011) Ge Liu et al.   PLoS One

Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)

(2011) David N. Taylor et al.   VACCINE

Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection

(2011) Seol Hee Hong et al.   VACCINE

Salmonella flagellin enhances mucosal immunity of avian influenza vaccine in chickens

(2011) Hso-Chi Chaung et al.   VETERINARY MICROBIOLOGY

Enhanced Mucosal Immune Responses to HIV Virus-Like Particles Containing a Membrane-Anchored Adjuvant

(2011) E. V. Vassilieva et al.   mBio

TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin

(2010) Matam Vijay-Kumar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

(2010) Qing Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Flagellin as an Adjuvant: Cellular Mechanisms and Potential

(2010) S. B. Mizel et al.   JOURNAL OF IMMUNOLOGY

Antigen-Containing Liposomes Engrafted with Flagellin-Related Peptides Are Effective Vaccines That Can Induce Potent Antitumor Immunity and Immunotherapeutic Effect

(2010) A. Faham et al.   JOURNAL OF IMMUNOLOGY

Stimulation of Human Dendritic Cells by Wild-Type and M Protein Mutant Vesicular Stomatitis Viruses Engineered To Express Bacterial Flagellin

(2010) M. Ahmed et al.   JOURNAL OF VIROLOGY

Prophylactic and therapeutic implications of toll-like receptor ligands

(2010) Mona Hedayat et al.   MEDICINAL RESEARCH REVIEWS

Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myeloid DC

(2010) Stefan Schülke et al.   MOLECULAR IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Immunopotentiation of Trivalent Influenza Vaccine When Given with VAX102, a Recombinant Influenza M2e Vaccine Fused to the TLR5 Ligand Flagellin

(2010) H. Keipp Talbot et al.   PLoS One

Safety and immunogenicity of a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125) in healthy young adults

(2010) John J. Treanor et al.   VACCINE

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE

A Recombinant Flagellin-Poxvirus Fusion Protein Vaccine Elicits Complement-Dependent Protection Against Respiratory Challenge with Vaccinia Virus in Mice

(2010) Kristen N. Delaney et al.   VIRAL IMMUNOLOGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Heat-shock protein vaccines as active immunotherapy against human gliomas

(2009) Isaac Yang et al.   Expert Review of Anticancer Therapy

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Immune responses of TLR5+ lamina propria dendritic cells in enterobacterial infection

(2009) Satoshi Uematsu et al.   JOURNAL OF GASTROENTEROLOGY

Modulation of adaptive immunity with Toll-like receptors

(2009) Santhakumar Manicassamy et al.   SEMINARS IN IMMUNOLOGY

Superior efficacy of a recombinant flagellin:H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin

(2009) Langzhou Song et al.   VACCINE

CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein

(2009) Catarina J.M. Braga et al.   VACCINE

Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine

(2009) Ioanna Skountzou et al.   VACCINE

Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy

(2008) C Tosch et al.   CANCER GENE THERAPY

Flagellin-F1-V Fusion Protein Is an Effective Plague Vaccine in Mice and Two Species of Nonhuman Primates

(2008) S. B. Mizel et al.   Clinical and Vaccine Immunology

Dendritic Cell and NK Cell Reciprocal Cross Talk Promotes Gamma Interferon-Dependent Immunity to Blood-Stage Plasmodium chabaudi AS Infection in Mice

(2008) R. Ing et al.   INFECTION AND IMMUNITY

Engineered Expression of the TLR5 Ligand Flagellin Enhances Paramyxovirus Activation of Human Dendritic Cell Function

(2008) S. Arimilli et al.   JOURNAL OF VIROLOGY

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY

Efficacious Recombinant Influenza Vaccines Produced by High Yield Bacterial Expression: A Solution to Global Pandemic and Seasonal Needs

(2008) Langzhou Song et al.   PLoS One

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

(2008) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE

New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin

(2008) Daniel Y. Bargieri et al.   VACCINE

Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells

(2007) François Vanhoutte et al.   IMMUNOLOGY LETTERS

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

(2007) James W. Huleatt et al.   VACCINE