The Adjuvant Activity of Alphavirus Replicons Is Enhanced by Incorporating the Microbial Molecule Flagellin into the Replicon

Deletion of Flagellin's Hypervariable Region Abrogates Antibody-Mediated Neutralization and Systemic Activation of TLR5-Dependent Immunity

(2014) C. Nempont et al.   JOURNAL OF IMMUNOLOGY

Stimulation by TLR5 Modulates Osteoclast Differentiation through STAT1/IFN- 

(2014) H. Ha et al.   JOURNAL OF IMMUNOLOGY

Regulation of effector and memory T-cell functions by type I interferon

(2011) Jonathan P. Huber et al.   IMMUNOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)

(2011) David N. Taylor et al.   VACCINE

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

Enhanced Mucosal Immune Responses to HIV Virus-Like Particles Containing a Membrane-Anchored Adjuvant

(2011) E. V. Vassilieva et al.   mBio

Recombinant flagellins with partial deletions of the hypervariable domain lose antigenicity but not mucosal adjuvancy

(2010) Fang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Kinase R Contributes to Immunity against Specific Viruses by Regulating Interferon mRNA Integrity

(2010) Oliver Schulz et al.   Cell Host & Microbe

TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin

(2010) Matam Vijay-Kumar et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Flagellin as an Adjuvant: Cellular Mechanisms and Potential

(2010) S. B. Mizel et al.   JOURNAL OF IMMUNOLOGY

Stimulation of Human Dendritic Cells by Wild-Type and M Protein Mutant Vesicular Stomatitis Viruses Engineered To Express Bacterial Flagellin

(2010) M. Ahmed et al.   JOURNAL OF VIROLOGY

Semliki Forest Virus-Induced Endoplasmic Reticulum Stress Accelerates Apoptotic Death of Mammalian Cells

(2010) G. Barry et al.   JOURNAL OF VIROLOGY

TLR ligands induce synergistic interferon-β and interferon-λ1 gene expression in human monocyte-derived dendritic cells

(2010) Sanna M. Mäkelä et al.   MOLECULAR IMMUNOLOGY

Immunopotentiation of Trivalent Influenza Vaccine When Given with VAX102, a Recombinant Influenza M2e Vaccine Fused to the TLR5 Ligand Flagellin

(2010) H. Keipp Talbot et al.   PLoS One

Safety and immunogenicity of a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125) in healthy young adults

(2010) John J. Treanor et al.   VACCINE

Induction of adaptive immunity by flagellin does not require robust activation of innate immunity

(2009) Catherine J. Sanders et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response

(2009) G. Barry et al.   JOURNAL OF GENERAL VIROLOGY

Direct Stimulation of tlr5+/+ CD11c+ Cells Is Necessary for the Adjuvant Activity of Flagellin

(2009) J. T. Bates et al.   JOURNAL OF IMMUNOLOGY

Adenovirus-mediated gene transfer of pathogen-associated molecular patterns for cancer immunotherapy

(2008) C Tosch et al.   CANCER GENE THERAPY

Engineered Expression of the TLR5 Ligand Flagellin Enhances Paramyxovirus Activation of Human Dendritic Cell Function

(2008) S. Arimilli et al.   JOURNAL OF VIROLOGY

Incorporation of Membrane-Anchored Flagellin into Influenza Virus-Like Particles Enhances the Breadth of Immune Responses

(2008) B.-Z. Wang et al.   JOURNAL OF VIROLOGY

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines

(2008) Joseph M. Thompson et al.   VACCINE

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

(2007) James W. Huleatt et al.   VACCINE