Prophylactic and therapeutic implications of toll-like receptor ligands

New Insight in LPS Antagonist

(2012) A. Ianaro et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Five year safety and immunogenicity of GlaxoSmithKline's candidate malaria vaccine RTS,S/AS02 following administration to semi-immune adult men living in a malaria-endemic region of The Gambia

(2010) Kalifa Bojang et al.   Human vaccines & immunotherapeutics

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

(2009) Richard T Lester et al.   AIDS

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins

(2009) Susan Carpenter et al.   BIOCHEMICAL JOURNAL

Progress on the Induction of Neutralizing Antibodies Against HIV Type 1 (HIV-1)

(2009) Michael Vaine et al.   BIODRUGS

Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands

(2009) Claudius Grossmann et al.   BMC IMMUNOLOGY

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Expression Levels of TLRs Involved in Viral Recognition in PBMCs from HIV-1-Infected Patients Failing Antiretroviral Therapy

(2009) Carolina Scagnolari et al.   INTERVIROLOGY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Complete Resolution of Paget Disease of the Vulva With Imiquimod Cream

(2009) Kenneth D. Hatch et al.   Journal of Lower Genital Tract Disease

Lipopolysaccharide-induced inflammatory cytokine production by Schwann's cells dependent upon TLR4 expression

(2009) Hsiao-Nan Hao et al.   JOURNAL OF NEUROIMMUNOLOGY

A class C CpG toll-like receptor 9 agonist successfully induces robust interferon-alpha production by plasmacytoid dendritic cells from patients chronically infected with hepatitis C

(2009) N. A. Libri et al.   JOURNAL OF VIRAL HEPATITIS

Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women

(2009) J Paavonen et al.   LANCET

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Toll-Like Receptor 4 Decoy, TOY, Attenuates Gram-Negative Bacterial Sepsis

(2009) Keehoon Jung et al.   PLoS One

Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4

(2009) T. Roger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY

(2009) Thiruma V. Arumugam et al.   SHOCK

Ampligen: A potential toll-like 3 receptor adjuvant for immunotherapy of cancer

(2009) B. Jasani et al.   VACCINE

Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine

(2009) Ioanna Skountzou et al.   VACCINE

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Phagocytosis and intracellular killing of MD-2 opsonized Gram-negative bacteria depend on TLR4 signaling

(2008) V. Jain et al.   BLOOD

Toll-Like Receptors

(2008) Benjamin Erickson et al.   Cardiology in Review

Flagellin-F1-V Fusion Protein Is an Effective Plague Vaccine in Mice and Two Species of Nonhuman Primates

(2008) S. B. Mizel et al.   Clinical and Vaccine Immunology

Structures of TLR–ligand complexes

(2008) Mi Sun Jin et al.   CURRENT OPINION IN IMMUNOLOGY

Human Papillomavirus Types 16 and 18 Vaccine (Recombinant, AS04 Adjuvanted, Adsorbed) [Cervarix???]

(2008) Susan J Keam et al.   DRUGS

Yaaautoimmune phenotypes are conferred by overexpression of TLR7

(2008) Anna‐Marie Fairhurst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

(2008) Tomohiro Kawamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Candida albicansphospholipomannan triggers inflammatory responses of human keratinocytes through Toll-like receptor 2

(2008) Min Li et al.   EXPERIMENTAL DERMATOLOGY

Toll-like receptor modulation: A novel therapeutic strategy in cardiovascular disease?

(2008) Athanasios Katsargyris et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease

(2008) Megan E. Himmel et al.   IMMUNOLOGY

Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction

(2008) M. Shingai et al.   INTERNATIONAL IMMUNOLOGY

Randomized Phase II Trial of a Toll-Like Receptor 9 Agonist Oligodeoxynucleotide, PF-3512676, in Combination With First-Line Taxane Plus Platinum Chemotherapy for Advanced-Stage Non–Small-Cell Lung Cancer

(2008) Christian Manegold et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase 1 Evaluation of Intralesionally Injected TLR9-agonist PF-3512676 in Patients With Basal Cell Carcinoma or Metastatic Melanoma

(2008) Maja A. Hofmann et al.   JOURNAL OF IMMUNOTHERAPY

Tracking the Toll of Kidney Disease

(2008) A. C. Shirali et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Discovery and Development of Toll-Like Receptor 4 (TLR4) Antagonists: A New Paradigm for Treating Sepsis and Other Diseases

(2008) Carlos G. Leon et al.   PHARMACEUTICAL RESEARCH

Efficacious Recombinant Influenza Vaccines Produced by High Yield Bacterial Expression: A Solution to Global Pandemic and Seasonal Needs

(2008) Langzhou Song et al.   PLoS One

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

(2008) C. Trumpfheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

(2008) L. G. Burdelya et al.   SCIENCE

The Roles of Pathogen-Associated Molecular Patterns in Atherosclerosis

(2008) Clett Erridge   TRENDS IN CARDIOVASCULAR MEDICINE

New horizons in adjuvants for vaccine development

(2008) Steven G. Reed et al.   TRENDS IN IMMUNOLOGY

Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond

(2008) Amit Lahiri et al.   VACCINE

New malaria vaccine candidates based on the Plasmodium vivax Merozoite Surface Protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin

(2008) Daniel Y. Bargieri et al.   VACCINE

Toll-like receptors and autoimmunity

(2007) Julia Hurst et al.   AUTOIMMUNITY REVIEWS

Toll-like receptors, cytokines and HIV-1

(2007) Catherine M. Sanders et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin

(2007) James W. Huleatt et al.   VACCINE