Adjuvant for vaccine immunotherapy of cancer - focusing on Toll-like receptor 2 and 3 agonists for safely enhancing antitumor immunity

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling

(2015) Akira Maruyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Translocon Protein Sec61 Mediates Antigen Transport from Endosomes in the Cytosol for Cross-Presentation to CD8+ T Cells

(2015) Matthias Zehner et al.   IMMUNITY

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

(2015) Stephen M. Ansell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Links between recognition and degradation of cytoplasmic viral RNA in innate immune response

(2015) Hiroyuki Oshiumi et al.   REVIEWS IN MEDICAL VIROLOGY

Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo

(2015) Misako Matsumoto et al.   Nature Communications

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo

(2015) R. Takemura et al.   Cancer Immunology Research

Dectin-2 Is a Direct Receptor for Mannose-Capped Lipoarabinomannan of Mycobacteria

(2014) Akiko Yonekawa et al.   IMMUNITY

TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction

(2014) Julianne Stack et al.   JOURNAL OF IMMUNOLOGY

Molecular Mechanisms of TLR2-Mediated Antigen Cross-Presentation in Dendritic Cells

(2014) K.-Y. Shen et al.   JOURNAL OF IMMUNOLOGY

INAM Plays a Critical Role in IFN-γ Production by NK Cells Interacting with Polyinosinic-Polycytidylic Acid–Stimulated Accessory Cells

(2014) Jun Kasamatsu et al.   JOURNAL OF IMMUNOLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Characterization of the Receptors for Mycobacterial Cord Factor in Guinea Pig

(2014) Kenji Toyonaga et al.   PLoS One

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer

(2013) Tsukasa Seya et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cutting Edge: IL-12 and Type I IFN Differentially Program CD8 T Cells for Programmed Death 1 Re-expression Levels and Tumor Control

(2013) M. Y. Gerner et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells Confer Tumor-Suppressive Functions on Natural Killer Cells via Polyinosinic:Polycytidylic Acid Treatment in Mouse Tumor Models

(2013) Hiroaki Shime et al.   Journal of Innate Immunity

Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA

(2013) Megumi Tatematsu et al.   Nature Communications

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients

(2012) P. Sabbatini et al.   CLINICAL CANCER RESEARCH

Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

(2012) Philipp Yu et al.   IMMUNITY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

(2012) H. Shime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting pattern recognition receptors in cancer immunotherapy

(2012) Nadège Goutagny et al.   Targeted Oncology

Trial Watch

(2012) Lorenzo Galluzzi et al.   OncoImmunology

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c+/CD8α+dendritic cells

(2012) Masahiro Azuma et al.   OncoImmunology

TLR3 as a Biomarker for the Therapeutic Efficacy of Double-stranded RNA in Breast Cancer

(2011) B. Salaun et al.   CANCER RESEARCH

Direct Effects of Type I Interferons on Cells of the Immune System

(2011) S. Hervas-Stubbs et al.   CLINICAL CANCER RESEARCH

A New Subset of CD103+CD8 + Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity

(2011) K. Fujimoto et al.   JOURNAL OF IMMUNOLOGY

DNA released from dying host cells mediates aluminum adjuvant activity

(2011) Thomas Marichal et al.   NATURE MEDICINE

Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands

(2010) R. Conforti et al.   CANCER RESEARCH

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation

(2010) Takashi Ebihara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Peptide Sequence of Diacyl Lipopeptides Determines Dendritic Cell TLR2-Mediated NK Activation

(2010) Masahiro Azuma et al.   PLoS One

CD8 Cells of Patients with Diffuse Cutaneous Leishmaniasis Display Functional Exhaustion: The Latter Is Reversed, In Vitro, by TLR2 Agonists

(2010) Joselín Hernández-Ruiz et al.   PLoS Neglected Tropical Diseases

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle

(2009) Eri Ishikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Poly I:C-Induced Activation of NK Cells by CD8 + Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

(2009) T. Miyake et al.   JOURNAL OF IMMUNOLOGY

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

(2009) Sunhwa Kim et al.   NATURE

Innate immune therapy with a Bacillus Calmette-Guérin cell wall skeleton after radical surgery for non-small cell lung cancer: A case-control study

(2009) Ken Kodama et al.   SURGERY TODAY

Activation of Toll-like receptor 2 by a novel preparation of cell wall skeleton from Mycobacterium bovis BCG Tokyo (SMP-105) sufficiently enhances immune responses against tumors

(2008) Masashi Murata   CANCER SCIENCE

Hepatitis C virus–infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells

(2008) Takashi Ebihara et al.   HEPATOLOGY

RNA-based viral immunity initiated by the Dicer family of host immune receptors

(2008) Roghiyh Aliyari et al.   IMMUNOLOGICAL REVIEWS

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY