Combination of adjuvants: the future of vaccine design

Bacillus Calmette-Guerin (BCG) immunotherapy for bladder cancer: Current understanding and perspectives on engineered BCG vaccine

(2012) Koji Kawai et al.   CANCER SCIENCE

Mycobacterium tuberculosis Inhibits Neutrophil Apoptosis, Leading to Delayed Activation of Naive CD4 T cells

(2012) Robert Blomgran et al.   Cell Host & Microbe

Phase I Trial of Overlapping Long Peptides from a Tumor Self-Antigen and Poly-ICLC Shows Rapid Induction of Integrated Immune Response in Ovarian Cancer Patients

(2012) P. Sabbatini et al.   CLINICAL CANCER RESEARCH

HIV-1, interferon and the interferon regulatory factor system: An interplay between induction, antiviral responses and viral evasion

(2012) Giulia Marsili et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8+T-cell responses in melanoma patients

(2012) Simone M. Goldinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Development and evaluation of AS03, an Adjuvant System containing α-tocopherol and squalene in an oil-in-water emulsion

(2012) Nathalie Garçon et al.   Expert Review of Vaccines

Cervarix®: a bivalent vaccine against HPV types 16 and 18, with cross-protection against other high-risk HPV types

(2012) Anne Szarewski   Expert Review of Vaccines

The history of MF59®adjuvant: a phoenix that arose from the ashes

(2012) Derek T O’Hagan et al.   Expert Review of Vaccines

TLR8 and NOD signaling synergistically induce the production of IL-1β and IL-23 in monocyte-derived DCs and enhance the expression of the feedback inhibitor SOCS2

(2012) Harald Schwarz et al.   IMMUNOBIOLOGY

MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice

(2012) Ming Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mycobacterium tuberculosisControls MicroRNA-99b (miR-99b) Expression in Infected Murine Dendritic Cells to Modulate Host Immunity

(2012) Yogesh Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined TLR Stimulation With Pam3Cys and Poly I

(2012) So Nai Lim et al.   JOURNAL OF IMMUNOTHERAPY

Modulating immunity as a therapy for bacterial infections

(2012) Robert E. W. Hancock et al.   NATURE REVIEWS MICROBIOLOGY

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Humoral Immune Responses to a Single Allele PfAMA1 Vaccine in Healthy Malaria-Naïve Adults

(2012) Edmond J. Remarque et al.   PLoS One

Comparison of the immune responses to the CIA06-adjuvanted human papillomavirus L1 VLP vaccine with those against the licensed HPV vaccine Cervarix™ in mice

(2012) Ji Eun Han et al.   VACCINE

Inactivated HSV-2 in MPL/alum adjuvant provides nearly complete protection against genital infection and shedding following long term challenge and rechallenge

(2012) Christopher S. Morello et al.   VACCINE

Insect cell-expressed hemagglutinin with CpG oligodeoxynucleotides plus alum as an adjuvant is a potential pandemic influenza vaccine candidate

(2012) Minqing Gong et al.   VACCINE

Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice

(2012) Najoua Dendouga et al.   VACCINE

Improved CD4+ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: A randomized trial

(2012) Isabel Leroux-Roels et al.   VACCINE

Enhancement of humoral immunity in mice by coupling pUCpGs10 and aluminium to the HCV recombinant immunogen

(2012) Na Zhan et al.   Virology Journal

Trial Watch

(2012) Lorenzo Galluzzi et al.   OncoImmunology

Trial watch: FDA-approved Toll-like receptor agonists for cancer therapy

(2012) Erika Vacchelli et al.   OncoImmunology

An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4+ T Cell Responses in Seronegative Volunteers

(2011) Eva Van Braeckel et al.   CLINICAL INFECTIOUS DISEASES

Role of bacillus Calmette–Guérin in the treatment of advanced melanoma

(2011) John H Stewart et al.   Expert Review of Anticancer Therapy

ISCOMATRIX vaccines mediate CD8+ T-cell cross-priming by a MyD88-dependent signaling pathway

(2011) Nicholas S Wilson et al.   IMMUNOLOGY AND CELL BIOLOGY

A combination of the TLR4 agonist CIA05 and alum promotes the immune responses to Bacillus anthracis protective antigen in mice

(2011) Seo Ri Wui et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Recombinant glycoprotein B vaccine formulation with Toll-like receptor 9 agonist and immune-stimulating complex induces specific immunity against multiple strains of cytomegalovirus

(2011) V. Dasari et al.   JOURNAL OF GENERAL VIROLOGY

ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells

(2011) P. Duewell et al.   JOURNAL OF IMMUNOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Targeting TLRs Expands the Antibody Repertoire in Response to a Malaria Vaccine

(2011) S. R. Wiley et al.   Science Translational Medicine

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

(2011) Philippe Denoël et al.   VACCINE

Marked enhancement of the immune response to BioThrax® (Anthrax Vaccine Adsorbed) by the TLR9 agonist CPG 7909 in healthy volunteers

(2011) Dianna Rynkiewicz et al.   VACCINE

Hepatitis C virus soluble E2 in combination with QuilA and CpG ODN induces neutralizing antibodies in mice

(2011) Marloes A. Naarding et al.   VACCINE

Dysregulation of human Toll-like receptor function in aging

(2010) Albert C. Shaw et al.   AGEING RESEARCH REVIEWS

Mycobacterium bovisBacillus Calmette-Guérin-Induced Macrophage Cytotoxicity against Bladder Cancer Cells

(2010) Yi Luo et al.   Clinical & Developmental Immunology

The role of inflammasomes in the immunostimulatory effects of particulate vaccine adjuvants

(2010) James Harris et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Patented cancer vaccines: the promising leads

(2010) Luigi Aurisicchio et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Combination adjuvants: the next generation of adjuvants?

(2010) George Mutwiri et al.   Expert Review of Vaccines

ISCOMATRIX™ vaccines: Safety in human clinical studies

(2010) Andrew McKenzie et al.   Human vaccines & immunotherapeutics

Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation

(2010) Alexandre Garin et al.   IMMUNITY

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma

(2010) Collin Jacobs et al.   INTERNATIONAL JOURNAL OF CANCER

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

(2010) Qing Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Mycobacterium tuberculosis and TLR2 Agonists Inhibit Induction of Type I IFN and Class I MHC Antigen Cross Processing by TLR9

(2010) D. P. Simmons et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Directs Immunofocusing of CD8+ T Cell Responses Despite Vaccination

(2010) J. S. Woodworth et al.   JOURNAL OF IMMUNOLOGY

Zymosan enhances the mucosal adjuvant activity of poly(I:C) in a nasal influenza vaccine

(2010) Akira Ainai et al.   JOURNAL OF MEDICAL VIROLOGY

Intranasal administration of adjuvant-combined vaccine protects monkeys from challenge with the highly pathogenic influenza A H5N1 virus

(2010) Takeshi Ichinohe et al.   JOURNAL OF MEDICAL VIROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Acquisition of Adult-Like TLR4 and TLR9 Responses during the First Year of Life

(2010) Muriel Nguyen et al.   PLoS One

Hepatitis A and Hepatitis C Viruses: Divergent Infection Outcomes Marked by Similarities in Induction and Evasion of Interferon Responses

(2010) Lin Qu et al.   SEMINARS IN LIVER DISEASE

Vaccine adjuvants: A priority for vaccine research

(2010) Ali M. Harandi et al.   VACCINE

Unmet needs in modern vaccinology

(2010) Geert Leroux-Roels   VACCINE

TLR-based immune adjuvants

(2010) Folkert Steinhagen et al.   VACCINE

Codelivery of adjuvants at the primary immunization site is essential for evoking a robust immune response to neoglycoconjugates

(2010) Dodi Safari et al.   VACCINE

Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands

(2009) Claudius Grossmann et al.   BMC IMMUNOLOGY

Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life

(2009) M.E. Belderbos et al.   CLINICAL IMMUNOLOGY

Immunobiology of Human Cytomegalovirus: from Bench to Bedside

(2009) T. Crough et al.   CLINICAL MICROBIOLOGY REVIEWS

Evaluation of Vaccines for H5N1 Influenza Virus in Ferrets Reveals the Potential for Protective Single-Shot Immunization

(2009) D. Middleton et al.   JOURNAL OF VIROLOGY

Unleashing the therapeutic potential of NOD-like receptors

(2009) Kaoru Geddes et al.   NATURE REVIEWS DRUG DISCOVERY

Prepandemic Influenza Vaccine H5N1 (Split Virion, Inactivated, Adjuvanted) [Prepandrix™]

(2008) Natalie J Carter et al.   BIODRUGS

Signalling adaptors used by Toll-like receptors: An update

(2008) Elaine F. Kenny et al.   CYTOKINE

Epaxal®: a virosomal vaccine to prevent hepatitis A infection

(2008) Patrick A Bovier   Expert Review of Vaccines

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

(2008) Luke A.J. O'Neill   IMMUNITY

Pattern recognition receptors and control of adaptive immunity

(2008) Noah W. Palm et al.   IMMUNOLOGICAL REVIEWS

Immunization With Analog Peptide in Combination With CpG and Montanide Expands Tumor Antigen-specific CD8+ T Cells in Melanoma Patients

(2008) Julien Fourcade et al.   JOURNAL OF IMMUNOTHERAPY

Varicella Vaccine in the United States: A Decade of Prevention and the Way Forward

(2008) Anne A. Gershon et al.   JOURNAL OF INFECTIOUS DISEASES

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines

(2008) Q. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An update of prophylactic human papillomavirus L1 virus-like particle vaccine clinical trial results

(2008) John T. Schiller et al.   VACCINE