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Title
Drugs in Development for Malaria
Authors
Keywords
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Journal
DRUGS
Volume 78, Issue 9, Pages 861-879
Publisher
Springer Nature
Online
2018-05-25
DOI
10.1007/s40265-018-0911-9
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Note: Only part of the references are listed.- Characterization of the Preclinical Pharmacology of the New 2-Aminomethylphenol, JPC-3210, for Malaria Treatment and Prevention
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- (2017) Mihály Sulyok et al. LANCET INFECTIOUS DISEASES
- New developments in anti-malarial target candidate and product profiles
- (2017) Jeremy N. Burrows et al. MALARIA JOURNAL
- Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin–piperaquine in the south of Vietnam
- (2017) Ngo Viet Thanh et al. MALARIA JOURNAL
- Managing intellectual property to develop medicines for the world's poorest
- (2017) Sylvie Fonteilles-Drabek et al. NATURE REVIEWS DRUG DISCOVERY
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- (2017) Armiyaw S. Nasamu et al. SCIENCE
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- (2017) Bridget E. Barber et al. TRENDS IN PARASITOLOGY
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- (2017) Stefano Pegoraro et al. Nature Communications
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- (2017) Somporn Saiwaew et al. PLoS One
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- (2017) Anna M. Leitgeb et al. PLoS One
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- (2016) James S. McCarthy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2016) David M. Plouffe et al. Cell Host & Microbe
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- (2016) Christoph Boss et al. ChemMedChem
- Declining Efficacy of Artemisinin Combination Therapy AgainstP. FalciparumMalaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors
- (2016) Aung Pyae Phyo et al. CLINICAL INFECTIOUS DISEASES
- Ivermectin: a complimentary weapon against the spread of malaria?
- (2016) Haoues Alout et al. Expert Review of Anti-Infective Therapy
- Efficacy of OZ439 (artefenomel) against earlyPlasmodium falciparumblood-stage malaria infection in healthy volunteers
- (2016) James S. McCarthy et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
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- (2016) Aung Pyae Phyo et al. LANCET INFECTIOUS DISEASES
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- (2016) Pamela L. St Jean et al. MALARIA JOURNAL
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- (2016) Neelima Mishra et al. MALARIA JOURNAL
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- (2016) Amy Maxmen NATURE
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- (2016) Nobutaka Kato et al. NATURE
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- (2016) Didier Ménard et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2014) Ric N Price et al. LANCET INFECTIOUS DISEASES
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- (2013) Michael J. Delves et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- (2013) Anne-Marie Zeeman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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- Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
- (2013) Natalie J. Spillman et al. Cell Host & Microbe
- Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double-blind, randomised, phase 2b dose-selection study
- (2013) Alejandro Llanos-Cuentas et al. LANCET
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- (2013) Case W. McNamara et al. NATURE
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- (2013) Frédéric Ariey et al. NATURE
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- (2012) Charles W. Jefford CURRENT TOPICS IN MEDICINAL CHEMISTRY
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- (2012) Y. Yuthavong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) S. A. Charman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) S. Meister et al. SCIENCE
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- (2010) Arjen M Dondorp et al. LANCET
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- (2010) M. Rottmann et al. SCIENCE
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- (2009) J. Tarning et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Coartem®: the journey to the clinic
- (2009) Zulfiqarali G Premji MALARIA JOURNAL
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- (2009) Arjen M. Dondorp et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2008) N. P. D. Nanayakkara et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Evidence of Artemisinin-Resistant Malaria in Western Cambodia
- (2008) Harald Noedl et al. NEW ENGLAND JOURNAL OF MEDICINE
- Safety and Efficacy of Methylene Blue Combined with Artesunate or Amodiaquine for Uncomplicated Falciparum Malaria: A Randomized Controlled Trial from Burkina Faso
- (2008) Augustin Zoungrana et al. PLoS One
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