Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action

A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle

(2015) Paul M. O'Neill et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents

(2015) Leon Jacobs et al.   ChemMedChem

Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites

(2015) Nuno A. L. Pereira et al.   ChemMedChem

Targeting the Erythrocytic and Liver Stages of Malaria Parasites withs-Triazine-Based Hybrids

(2015) Catarina A. B. Rodrigues et al.   ChemMedChem

Discovery and optimisation studies of antimalarial phenotypic hits

(2015) Alka Mital et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

First-in-Humans Study of the Safety, Tolerability, and Pharmacokinetics of ACT-451840, a New Chemical Entity with Antimalarial Activity

(2014) Shirin Bruderer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Realistically, how far are we from a universal malaria drug?

(2014) Marco A Biamonte   Future Medicinal Chemistry

Recent advances in malaria drug discovery

(2013) Marco A. Biamonte et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metalloantimalarials

(2013) Paloma F. Salas et al.   CHEMICAL REVIEWS

Synthesis of a Potent Antimalarial Agent through Natural Products Conjugation

(2013) Michela Bruno et al.   ChemMedChem

UV-triggered Affinity Capture Identifies Interactions between thePlasmodium falciparumMultidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells

(2013) Ralf Brunner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized, controlled trial of the long term safety, immunogenicity and efficacy of RTS,S/AS02D malaria vaccine in infants living in a malaria-endemic region

(2013) Salim Abdulla et al.   MALARIA JOURNAL

Global Phenotypic Screening for Antimalarials

(2012) W. Armand Guiguemde et al.   CHEMISTRY & BIOLOGY

Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

(2012) Arnab K. Chatterjee et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Emerging drugs for malaria

(2012) Serena Tschan et al.   EXPERT OPINION ON EMERGING DRUGS

Identification of a New Chemical Class of Antimalarials

(2012) Ralf Brunner et al.   JOURNAL OF INFECTIOUS DISEASES

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Priming the antimalarial pipeline

(2010) David A. Fidock   NATURE

Erratum: Artemisinin resistance: current status and scenarios for containment

(2010) Arjen M. Dondorp et al.   NATURE REVIEWS MICROBIOLOGY

Intrahost modeling of artemisinin resistance in Plasmodium falciparum

(2010) S. Saralamba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malaria's Drug Miracle in Danger

(2010) M. Enserink   SCIENCE

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

Structure of thePlasmodium falciparumCircumsporozoite Protein, a Leading Malaria Vaccine Candidate

(2009) Matthew L. Plassmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New medicines to improve control and contribute to the eradication of malaria

(2009) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

Antimalarial Drugs – What is in Use and What is in the Pipeline

(2008) Martin Schlitzer   ARCHIV DER PHARMAZIE

A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes

(2008) Iñigo Angulo-Barturen et al.   PLoS One