Efficacy of OZ439 (artefenomel) against earlyPlasmodium falciparumblood-stage malaria infection in healthy volunteers

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

(2016) Aung Pyae Phyo et al.   LANCET INFECTIOUS DISEASES

Evaluating the Pharmacodynamic Effect of Antimalarial Drugs in Clinical Trials by Quantitative PCR

(2015) Louise Marquart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Global malaria eradication and the importance of Plasmodium falciparum epidemiology in Africa

(2015) Robert W Snow   BMC Medicine

Supporting malaria elimination with 21st century antimalarial agent drug discovery

(2015) Thierry T. Diagana   DRUG DISCOVERY TODAY

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker

(2015) Kyaw M Tun et al.   LANCET INFECTIOUS DISEASES

Malaria runs rings round artemisinin

(2015) Jeremy Burrows   NATURE

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Malaria medicines: a glass half full?

(2015) Timothy N. C. Wells et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization

(2013) Nicholas J. White   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

(2013) Xiaofang Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Designing the next generation of medicines for malaria control and eradication

(2013) Jeremy N Burrows et al.   MALARIA JOURNAL

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

(2012) Joerg J. Moehrle et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

(2012) Aung Pyae Phyo et al.   LANCET

Quantification of multiple infections of Plasmodium falciparum in vitro

(2012) Mark A Wacker et al.   MALARIA JOURNAL

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

(2012) Joel Tarning et al.   MALARIA JOURNAL

Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

(2011) Carrie A Morris et al.   MALARIA JOURNAL

A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers

(2011) Rebecca J Rockett et al.   MALARIA JOURNAL

Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

(2011) Jennifer A Flegg et al.   MALARIA JOURNAL

The parasite clearance curve

(2011) NJ White   MALARIA JOURNAL

A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs

(2011) James S. McCarthy et al.   PLoS One

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

(2011) S. A. Charman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacokinetics and Pharmacodynamics of Arterolane Maleate Following Multiple Oral Doses in Adult Patients WithP. falciparumMalaria

(2010) Anirudh Gautam et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Current Methods for Predicting Human Food Effect

(2008) Kimberley A. Lentz   AAPS Journal

Pharmacokinetics of dihydroartemisinin in Artekin tablets for single and repeated dosing in Chinese healthy volunteers

(2008) Xin Hong et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE