A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers
Authors
Keywords
-
Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 58, Issue 10, Pages 6209-6214
Publisher
American Society for Microbiology
Online
2014-08-12
DOI
10.1128/aac.03393-14
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Spiroindolone KAE609 for Falciparum and Vivax Malaria
- (2014) Nicholas J. White et al. NEW ENGLAND JOURNAL OF MEDICINE
- Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
- (2013) Natalie J. Spillman et al. Cell Host & Microbe
- Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages
- (2013) PAUL W. SMITH et al. PARASITOLOGY
- The Spiroindolone Drug Candidate NITD609 Potently Inhibits Gametocytogenesis and Blocks Plasmodium falciparum Transmission to Anopheles Mosquito Vector
- (2012) J. C. van Pelt-Koops et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Need for New Antimalarial Drugs Less Prone to Resistance
- (2012) Harald Noedl CURRENT PHARMACEUTICAL DESIGN
- Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents
- (2012) Advait Nagle et al. JOURNAL OF MEDICINAL CHEMISTRY
- Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
- (2012) Aung Pyae Phyo et al. LANCET
- Mechanistic Study of the Spiroindolones: A New Class of Antimalarials
- (2012) Bin Zou et al. MOLECULES
- Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents
- (2011) Tao Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Threat of Artemisinin-Resistant Malaria
- (2011) Arjen M. Dondorp et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ghloroquine excretion in semen following antimalarial-drug administration
- (2010) A. O. Adeeko et al. ANDROLOGIA
- Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
- (2010) Bryan K. S. Yeung et al. JOURNAL OF MEDICINAL CHEMISTRY
- Artemisinin resistance: current status and scenarios for containment
- (2010) Arjen M. Dondorp et al. NATURE REVIEWS MICROBIOLOGY
- Spiroindolones, a Potent Compound Class for the Treatment of Malaria
- (2010) M. Rottmann et al. SCIENCE
- Artemisinin-Resistant Malaria in Asia
- (2009) Harald Noedl et al. NEW ENGLAND JOURNAL OF MEDICINE
- Artemisinin Resistance inPlasmodium falciparumMalaria
- (2009) Arjen M. Dondorp et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evidence of Artemisinin-Resistant Malaria in Western Cambodia
- (2008) Harald Noedl et al. NEW ENGLAND JOURNAL OF MEDICINE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started