Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria

Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

(2015) B Darpo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Detection of QTc Effects in Small Studies-Implications for Replacing the Thorough QT Study

(2014) Georg Ferber et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Two-Day Regimen of Dihydroartemisinin-Piperaquine for Malaria Prevention Halted for Concern over Prolonged Corrected QT Interval

(2014) Jessica Manning et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The IQ-CSRC Prospective Clinical Phase 1 Study: “Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”

(2013) Borje Darpo et al.   ANNALS OF NONINVASIVE ELECTROCARDIOLOGY

Artemisinin resistance is a clear and present danger

(2013) Arjen M. Dondorp et al.   TRENDS IN PARASITOLOGY

Population Pharmacokinetics of Dihydroartemisinin and Piperaquine in Pregnant and Nonpregnant Women with Uncomplicated Malaria

(2012) Joel Tarning et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroCardiovascular Effects of Dihydroartemisin-Piperaquine Combination Compared with Other Antimalarials

(2012) Franco Borsini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

(2012) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early QT assessment - how can our confidence in the data be improved?

(2012) Borje Darpo et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Dihydroartemisinin/Piperaquine

(2012) Gillian M. Keating   DRUGS

Malarial cases presenting to a European urban Emergency Department

(2012) Tomás M. Breslin et al.   European Journal of Emergency Medicine

Considerations for Clinical Trial Design and Data Analyses of Thorough QT Studies Using Drug-Drug Interaction

(2010) Hao Zhu et al.   JOURNAL OF CLINICAL PHARMACOLOGY