Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell

Fluorinated Chaperone−β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease

(2017) M. Isabel García-Moreno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers

(2017) Thi Minh Nguyet Trinh et al.   Journal of Materials Chemistry B

Multivalency as an action principle in multimodal lectin recognition and glycosidase inhibition: a paradigm shift driven by carbon-based glyconanomaterials

(2017) Carmen Ortiz Mellet et al.   Journal of Materials Chemistry B

Magnetic Nanoparticles Coated with Thiomannosides or Iminosugars to Switch and Recycle Galactosidase Activity

(2017) Dimitri Alvarez-Dorta et al.   ChemistrySelect

Influence of the configurational pattern of sp2-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties

(2016) Elena M. Sánchez-Fernández et al.   CARBOHYDRATE RESEARCH

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition

(2016) Marta Abellán Flos et al.   CHEMISTRY-A EUROPEAN JOURNAL

Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels

(2016) Mathieu L. Lepage et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ultra-Fast Dendritic Growth Based on the Grafting of Fullerene Hexa-Adduct Macromonomers onto a Fullerene Core

(2016) David Sigwalt et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes

(2016) Fabien Stauffert et al.   NEW JOURNAL OF CHEMISTRY

Expanding the library of divalent fucosidase inhibitors with polyamino and triazole-benzyl bridged bispyrrolidines

(2016) Audrey Hottin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers

(2016) Audrey Hottin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Are enzymes sensitive to the multivalent effect? Emerging evidence with glycosidases

(2016) Camilla Matassini et al.   TETRAHEDRON LETTERS

pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases

(2015) Teresa Mena-Barragán et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anti-cancer Glycosidase Inhibitors from Natural Products: A Computational and Molecular Modelling Perspective

(2015) Ashona Singh et al.   Anti-Cancer Agents in Medicinal Chemistry

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

(2015) Mathieu L Lepage et al.   Beilstein Journal of Organic Chemistry

Polymeric Iminosugars Improve the Activity of Carbohydrate-Processing Enzymes

(2015) Yoan Brissonnet et al.   BIOCONJUGATE CHEMISTRY

Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack

(2015) Usman Ghani   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Toward a Molecular Lego Approach for the Diversity-Oriented Synthesis of Cyclodextrin Analogues Designed as Scaffolds for Multivalent Systems

(2015) Mathieu L. Lepage et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection

(2015) Antonio Muñoz et al.   Nature Chemistry

Synthesis and biological properties of multivalent iminosugars

(2015) Renaud Zelli et al.   NEW JOURNAL OF CHEMISTRY

Emerging trends in enzyme inhibition by multivalent nanoconstructs

(2015) Nasreddine Kanfar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2.2 A resolution cryo-EM structure of  -galactosidase in complex with a cell-permeant inhibitor

(2015) A. Bartesaghi et al.   SCIENCE

Self-organisation of dodeca-dendronized fullerene into supramolecular discs and helical columns containing a nanowire-like core

(2015) Sebastiano Guerra et al.   Chemical Science

Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

(2015) C. Matassini et al.   RSC Advances

Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted O-glycosides

(2015) Aloysius Siriwardena et al.   RSC Advances

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

(2015) Mario de la Mata et al.   Scientific Reports

Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

(2014) Mathieu L Lepage et al.   Beilstein Journal of Organic Chemistry

The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

(2014) Philippe Compain et al.   CHEMBIOCHEM

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

(2014) Colin Bonduelle et al.   CHEMICAL COMMUNICATIONS

The Impact of Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition in Fullerene Chemistry

(2014) Iwona Nierengarten et al.   CHEMICAL RECORD

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept

(2014) Sébastien G. Gouin   CHEMISTRY-A EUROPEAN JOURNAL

Fullerene Sugar Balls: A New Class of Biologically Active Fullerene Derivatives

(2014) Iwona Nierengarten et al.   Chemistry-An Asian Journal

A Convergent Strategy for the Synthesis of Second-Generation Iminosugar Clusters Using “Clickable” Trivalent Dendrons

(2014) Antoine Joosten et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Glycosidase inhibitors: a patent review (2008 – 2013)

(2014) Natércia F Brás et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Synthesis and glycosidase inhibition properties of triazole-linked calixarene–iminosugar clusters

(2014) Alberto Marra et al.   TETRAHEDRON

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

(2013) Antoine Joosten et al.   CHEMBIOCHEM

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors

(2013) Philippe Compain et al.   CHEMBIOCHEM

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate–protein interactions

(2013) Álvaro Martínez et al.   CHEMICAL SOCIETY REVIEWS

Bridging lectin binding sites by multivalent carbohydrates

(2013) Valentin Wittmann et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

(2013) Yoann M. Chabre et al.   CHEMICAL SOCIETY REVIEWS

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Thiyl Glycosylation of Propargylated Octasilsesquioxane: Synthesis and Lectin-Binding Properties of Densely Glycosylated Clusters on a Cubic Platform

(2013) Alberto Marra et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Low-generation dendrimers with a calixarene core and based on a chiralC2-symmetric pyrrolidine as iminosugar mimics

(2012) Marco Marradi et al.   Beilstein Journal of Organic Chemistry

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions

(2012) Francesca Cardona et al.   JOURNAL OF ORGANIC CHEMISTRY

Glycoside and peptide clustering around the octasilsesquioxane scaffold via photoinduced free-radical thiol–ene coupling. The observation of a striking glycoside cluster effect

(2012) Mauro Lo Conte et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

LacZβ-galactosidase: Structure and function of an enzyme of historical and molecular biological importance

(2012) Douglas H. Juers et al.   PROTEIN SCIENCE

Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection

(2012) Renato Ribeiro-Viana et al.   Nature Communications

Ser-796 of β-galactosidase (Escherichia coli) plays a key role in maintaining a balance between the opened and closed conformations of the catalytically important active site loop

(2011) Larisa J. Jancewicz et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Carbohydrate-Protein Interactions: A 3D View by NMR

(2011) Virginia Roldós et al.   CHEMBIOCHEM

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Bacterial Lectin FimH, a Target for Drug Discovery - Carbohydrate Inhibitors of Type 1 Fimbriae-Mediated Bacterial Adhesion

(2011) Mirja Hartmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential copper catalyzed alkyne–azide and thiol–ene click reactions for the multiple functionalization of fullerene hexaadducts

(2010) Julien Iehl et al.   CHEMICAL COMMUNICATIONS

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability

(2009) Raquel L. Lieberman et al.   BIOCHEMISTRY

Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions

(2009) Narayanaswamy Jayaraman   CHEMICAL SOCIETY REVIEWS

A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60

(2009) Julien Iehl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibitors Against Glycosidases as Medicines

(2009) Tetsuya Kajimoto et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Catalytic Mechanism of Human α-Galactosidase

(2009) Abigail I. Guce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosidase inhibition: assessing mimicry of the transition state

(2009) Tracey M. Gloster et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism

(2009) Tom Wennekes et al.   TETRAHEDRON-ASYMMETRY

Click chemistry for the efficient preparation of functionalized [60]fullerene hexakis-adducts

(2008) Julien Iehl et al.   CHEMICAL COMMUNICATIONS

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic insights into glycosidase chemistry

(2008) David J Vocadlo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Covalent inhibitors of glycosidases and their applications in biochemistry and biology

(2008) B. P Rempel et al.   GLYCOBIOLOGY

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Golgi  -mannosidase II cleaves two sugars sequentially in the same catalytic site

(2008) N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA