Glycosidase inhibitors: a patent review (2008 – 2013)

Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors

(2013) Rima Lahiri et al.   CHEMICAL SOCIETY REVIEWS

Conformational Analyses of the Reaction Coordinate of Glycosidases

(2011) Gideon J. Davies et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enzymatic glycosyl transfer: mechanisms and applications

(2011) Tom Desmet et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Pharmacological chaperone therapy for Gaucher disease: a patent review

(2011) Juan M Benito et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Iminosugars as therapeutic agents: recent advances and promising trends

(2011) Robert J Nash et al.   Future Medicinal Chemistry

QM/MM Study of the Catalytic Mechanism of GalNAc Removal from GM2 Ganglioside Catalyzed by Human β-HexosaminidaseA

(2011) Óscar Passos et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

(2011) Tracey M Gloster et al.   Nature Chemical Biology

Docking and SAR studies of salacinol derivatives as α-glucosidase inhibitors

(2010) Shinya Nakamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Iminosugars past, present and future: medicines for tomorrow

(2010) Graeme Horne et al.   DRUG DISCOVERY TODAY

QM/MM Studies on the β-Galactosidase Catalytic Mechanism: Hydrolysis and Transglycosylation Reactions

(2010) Natércia F. Brás et al.   Journal of Chemical Theory and Computation

Molecular Mechanism of the Glycosylation Step Catalyzed by Golgi α-Mannosidase II: A QM/MM Metadynamics Investigation

(2010) Luis Petersen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nucleotidylation of unsaturated carbasugar in validamycin biosynthesis

(2010) Jongtae Yang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and Glycosidase Inhibition of the Enantiomer of (−)-Steviamine, the First Example of a New Class of Indolizidine Alkaloid

(2010) Xiang-Guo Hu et al.   ORGANIC LETTERS

Approaches to labeling and identification of active site residues in glycosidases

(2010) Stephen G. Withers et al.   PROTEIN SCIENCE

Sugar-mimicking glycosidase inhibitors: bioactivity and application

(2009) N. Asano   CELLULAR AND MOLECULAR LIFE SCIENCES

Glycomimetics at the Mirror: Medicinal Chemistry of L-Iminosugars

(2009) Daniele D'Alonzo et al.   CURRENT MEDICINAL CHEMISTRY

Design and Synthesis of 5a-Carbaglycopyranosylamime Glycosidase Inhibitors

(2009) Seiichiro Ogawa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

DFT studies on the β-glycosidase catalytic mechanism: The deglycosylation step

(2009) Natércia F. Brás et al.   JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM

Molecular interaction of imino sugars with human α-galactosidase: Insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease

(2009) Kanako Sugawara et al.   MOLECULAR GENETICS AND METABOLISM

Glycosidase inhibition: assessing mimicry of the transition state

(2009) Tracey M. Gloster et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pandemic Influenza: An Inconvenient Mutation

(2009) S. P. Layne et al.   SCIENCE

Iminosugars: from botanical curiosities to licensed drugs

(2009) Bryan G. Winchester   TETRAHEDRON-ASYMMETRY

Docking and molecular dynamics studies on the stereoselectivity in the enzymatic synthesis of carbohydrates

(2009) Natércia F. Brás et al.   THEORETICAL CHEMISTRY ACCOUNTS

Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut Flora

(2008) Tracey M. Gloster et al.   CHEMISTRY & BIOLOGY

Mechanistic insights into glycosidase chemistry

(2008) David J Vocadlo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Molecular determinants of ligand specificity in family 11 carbohydrate binding modules - an NMR, X-ray crystallography and computational chemistry approach

(2008) Aldino Viegas et al.   FEBS Journal

Carbohydrate-binding modules from family 11: Understanding the binding mode of polysaccharides

(2008) N. F. Brás et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Mechanistic studies on the formation of glycosidase-substrate and glycosidase-inhibitor covalent intermediates

(2008) Natércia F. Brás et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Fabry's disease

(2008) Yuri A Zarate et al.   LANCET

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

(2008) Patrick J. Collins et al.   NATURE

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH