Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell
出版年份 2018 全文链接
标题
Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell
作者
关键词
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出版物
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 10, Pages 2483-2492
出版商
Wiley
发表日期
2017-12-28
DOI
10.1002/chem.201705600
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Fluorinated Chaperone−β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease
- (2017) M. Isabel García-Moreno et al. JOURNAL OF MEDICINAL CHEMISTRY
- Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers
- (2017) Thi Minh Nguyet Trinh et al. Journal of Materials Chemistry B
- Multivalency as an action principle in multimodal lectin recognition and glycosidase inhibition: a paradigm shift driven by carbon-based glyconanomaterials
- (2017) Carmen Ortiz Mellet et al. Journal of Materials Chemistry B
- Magnetic Nanoparticles Coated with Thiomannosides or Iminosugars to Switch and Recycle Galactosidase Activity
- (2017) Dimitri Alvarez-Dorta et al. ChemistrySelect
- Influence of the configurational pattern of sp2-iminosugar pseudo N-, S-, O- and C-glycosides on their glycoside inhibitory and antitumor properties
- (2016) Elena M. Sánchez-Fernández et al. CARBOHYDRATE RESEARCH
- Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition
- (2016) Marta Abellán Flos et al. CHEMISTRY-A EUROPEAN JOURNAL
- Iminosugar-Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels
- (2016) Mathieu L. Lepage et al. CHEMISTRY-A EUROPEAN JOURNAL
- Ultra-Fast Dendritic Growth Based on the Grafting of Fullerene Hexa-Adduct Macromonomers onto a Fullerene Core
- (2016) David Sigwalt et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Understanding multivalent effects in glycosidase inhibition using C-glycoside click clusters as molecular probes
- (2016) Fabien Stauffert et al. NEW JOURNAL OF CHEMISTRY
- Expanding the library of divalent fucosidase inhibitors with polyamino and triazole-benzyl bridged bispyrrolidines
- (2016) Audrey Hottin et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers
- (2016) Audrey Hottin et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Are enzymes sensitive to the multivalent effect? Emerging evidence with glycosidases
- (2016) Camilla Matassini et al. TETRAHEDRON LETTERS
- pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases
- (2015) Teresa Mena-Barragán et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Anti-cancer Glycosidase Inhibitors from Natural Products: A Computational and Molecular Modelling Perspective
- (2015) Ashona Singh et al. Anti-Cancer Agents in Medicinal Chemistry
- Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores
- (2015) Mathieu L Lepage et al. Beilstein Journal of Organic Chemistry
- Polymeric Iminosugars Improve the Activity of Carbohydrate-Processing Enzymes
- (2015) Yoan Brissonnet et al. BIOCONJUGATE CHEMISTRY
- Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack
- (2015) Usman Ghani EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Toward a Molecular Lego Approach for the Diversity-Oriented Synthesis of Cyclodextrin Analogues Designed as Scaffolds for Multivalent Systems
- (2015) Mathieu L. Lepage et al. JOURNAL OF ORGANIC CHEMISTRY
- Synthesis of giant globular multivalent glycofullerenes as potent inhibitors in a model of Ebola virus infection
- (2015) Antonio Muñoz et al. Nature Chemistry
- Synthesis and biological properties of multivalent iminosugars
- (2015) Renaud Zelli et al. NEW JOURNAL OF CHEMISTRY
- Emerging trends in enzyme inhibition by multivalent nanoconstructs
- (2015) Nasreddine Kanfar et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- 2.2 A resolution cryo-EM structure of -galactosidase in complex with a cell-permeant inhibitor
- (2015) A. Bartesaghi et al. SCIENCE
- Self-organisation of dodeca-dendronized fullerene into supramolecular discs and helical columns containing a nanowire-like core
- (2015) Sebastiano Guerra et al. Chemical Science
- Gold nanoparticles are suitable cores for building tunable iminosugar multivalency
- (2015) C. Matassini et al. RSC Advances
- Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted O-glycosides
- (2015) Aloysius Siriwardena et al. RSC Advances
- Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease
- (2015) Mario de la Mata et al. Scientific Reports
- Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores
- (2014) Mathieu L Lepage et al. Beilstein Journal of Organic Chemistry
- The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience
- (2014) Philippe Compain et al. CHEMBIOCHEM
- Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies
- (2014) Colin Bonduelle et al. CHEMICAL COMMUNICATIONS
- The Impact of Copper-Catalyzed Alkyne-Azide 1,3-Dipolar Cycloaddition in Fullerene Chemistry
- (2014) Iwona Nierengarten et al. CHEMICAL RECORD
- Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands
- (2014) Samy Cecioni et al. CHEMICAL REVIEWS
- Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept
- (2014) Sébastien G. Gouin CHEMISTRY-A EUROPEAN JOURNAL
- Fullerene Sugar Balls: A New Class of Biologically Active Fullerene Derivatives
- (2014) Iwona Nierengarten et al. Chemistry-An Asian Journal
- A Convergent Strategy for the Synthesis of Second-Generation Iminosugar Clusters Using “Clickable” Trivalent Dendrons
- (2014) Antoine Joosten et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Glycosidase inhibitors: a patent review (2008 – 2013)
- (2014) Natércia F Brás et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Synthesis and glycosidase inhibition properties of triazole-linked calixarene–iminosugar clusters
- (2014) Alberto Marra et al. TETRAHEDRON
- A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease
- (2013) Antoine Joosten et al. CHEMBIOCHEM
- The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters
- (2013) Camille Decroocq et al. CHEMBIOCHEM
- Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors
- (2013) Philippe Compain et al. CHEMBIOCHEM
- Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate–protein interactions
- (2013) Álvaro Martínez et al. CHEMICAL SOCIETY REVIEWS
- Bridging lectin binding sites by multivalent carbohydrates
- (2013) Valentin Wittmann et al. CHEMICAL SOCIETY REVIEWS
- Multivalent glycoconjugate syntheses and applications using aromatic scaffolds
- (2013) Yoann M. Chabre et al. CHEMICAL SOCIETY REVIEWS
- Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect
- (2013) Rocío Rísquez-Cuadro et al. CHEMISTRY-A EUROPEAN JOURNAL
- Thiyl Glycosylation of Propargylated Octasilsesquioxane: Synthesis and Lectin-Binding Properties of Densely Glycosylated Clusters on a Cubic Platform
- (2013) Alberto Marra et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases
- (2013) Yoan Brissonnet et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Low-generation dendrimers with a calixarene core and based on a chiralC2-symmetric pyrrolidine as iminosugar mimics
- (2012) Marco Marradi et al. Beilstein Journal of Organic Chemistry
- Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders
- (2012) Camille Decroocq et al. CHEMBIOCHEM
- Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions
- (2012) Francesca Cardona et al. JOURNAL OF ORGANIC CHEMISTRY
- Glycoside and peptide clustering around the octasilsesquioxane scaffold via photoinduced free-radical thiol–ene coupling. The observation of a striking glycoside cluster effect
- (2012) Mauro Lo Conte et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- LacZβ-galactosidase: Structure and function of an enzyme of historical and molecular biological importance
- (2012) Douglas H. Juers et al. PROTEIN SCIENCE
- Virus-like glycodendrinanoparticles displaying quasi-equivalent nested polyvalency upon glycoprotein platforms potently block viral infection
- (2012) Renato Ribeiro-Viana et al. Nature Communications
- Ser-796 of β-galactosidase (Escherichia coli) plays a key role in maintaining a balance between the opened and closed conformations of the catalytically important active site loop
- (2011) Larisa J. Jancewicz et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Carbohydrate-Protein Interactions: A 3D View by NMR
- (2011) Virginia Roldós et al. CHEMBIOCHEM
- The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition
- (2011) Maxime Durka et al. CHEMISTRY-A EUROPEAN JOURNAL
- The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters
- (2011) Camille Decroocq et al. CHEMISTRY-A EUROPEAN JOURNAL
- The Bacterial Lectin FimH, a Target for Drug Discovery - Carbohydrate Inhibitors of Type 1 Fimbriae-Mediated Bacterial Adhesion
- (2011) Mirja Hartmann et al. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
- Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect
- (2010) Philippe Compain et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Sequential copper catalyzed alkyne–azide and thiol–ene click reactions for the multiple functionalization of fullerene hexaadducts
- (2010) Julien Iehl et al. CHEMICAL COMMUNICATIONS
- Fullerene sugar balls
- (2010) Jean-François Nierengarten et al. CHEMICAL COMMUNICATIONS
- Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands
- (2010) David Deniaud et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability
- (2009) Raquel L. Lieberman et al. BIOCHEMISTRY
- Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions
- (2009) Narayanaswamy Jayaraman CHEMICAL SOCIETY REVIEWS
- A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60
- (2009) Julien Iehl et al. CHEMISTRY-A EUROPEAN JOURNAL
- Inhibitors Against Glycosidases as Medicines
- (2009) Tetsuya Kajimoto et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Catalytic Mechanism of Human α-Galactosidase
- (2009) Abigail I. Guce et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Maximising multivalency effects in protein–carbohydrate interactions
- (2009) Roland J. Pieters ORGANIC & BIOMOLECULAR CHEMISTRY
- Glycosidase inhibition: assessing mimicry of the transition state
- (2009) Tracey M. Gloster et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism
- (2009) Tom Wennekes et al. TETRAHEDRON-ASYMMETRY
- Click chemistry for the efficient preparation of functionalized [60]fullerene hexakis-adducts
- (2008) Julien Iehl et al. CHEMICAL COMMUNICATIONS
- Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins
- (2008) Anne Imberty et al. CHEMISTRY-A EUROPEAN JOURNAL
- Mechanistic insights into glycosidase chemistry
- (2008) David J Vocadlo et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Covalent inhibitors of glycosidases and their applications in biochemistry and biology
- (2008) B. P Rempel et al. GLYCOBIOLOGY
- The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics
- (2008) B. L. Cantarel et al. NUCLEIC ACIDS RESEARCH
- Multivalent iminosugars to modulate affinity and selectivity for glycosidases
- (2008) Jennifer Diot et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Golgi -mannosidase II cleaves two sugars sequentially in the same catalytic site
- (2008) N. Shah et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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