The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

(2014) Colin Bonduelle et al.   CHEMICAL COMMUNICATIONS

A Convergent Strategy for the Synthesis of Second-Generation Iminosugar Clusters Using “Clickable” Trivalent Dendrons

(2014) Antoine Joosten et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

(2013) Antoine Joosten et al.   CHEMBIOCHEM

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors

(2013) Philippe Compain et al.   CHEMBIOCHEM

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate–protein interactions

(2013) Álvaro Martínez et al.   CHEMICAL SOCIETY REVIEWS

Bridging lectin binding sites by multivalent carbohydrates

(2013) Valentin Wittmann et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

(2013) Yoann M. Chabre et al.   CHEMICAL SOCIETY REVIEWS

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Correctors of the basic trafficking defect of the mutant F508del-CFTR that causes cystic fibrosis

(2013) Véronique Birault et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Thiyl Glycosylation of Propargylated Octasilsesquioxane: Synthesis and Lectin-Binding Properties of Densely Glycosylated Clusters on a Cubic Platform

(2013) Alberto Marra et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Exploring a Multivalent Approach to α-L-Fucosidase Inhibition

(2013) Elena Moreno-Clavijo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Pharmacological Chaperones as Therapeutics for Lysosomal Storage Diseases

(2013) Robert E. Boyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines

(2013) Heidi M Sampson et al.   Orphanet Journal of Rare Diseases

Low-generation dendrimers with a calixarene core and based on a chiralC2-symmetric pyrrolidine as iminosugar mimics

(2012) Marco Marradi et al.   Beilstein Journal of Organic Chemistry

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of α-Linked Disaccharides; Implications for Glycosidase Inhibition

(2012) Elena M. Sánchez-Fernández et al.   CHEMISTRY-A EUROPEAN JOURNAL

Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions

(2012) Francesca Cardona et al.   JOURNAL OF ORGANIC CHEMISTRY

Carbohydrate Mimics and Lectins: A Source of New Drugs and Therapeutic Opportunities

(2012) Jose J. Reina et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Glycoside and peptide clustering around the octasilsesquioxane scaffold via photoinduced free-radical thiol–ene coupling. The observation of a striking glycoside cluster effect

(2012) Mauro Lo Conte et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection

(2012) C. M. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B

(2012) Benjamin H. Fraser et al.   MedChemComm

Carbohydrate-Protein Interactions: A 3D View by NMR

(2011) Virginia Roldós et al.   CHEMBIOCHEM

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Bacterial Lectin FimH, a Target for Drug Discovery - Carbohydrate Inhibitors of Type 1 Fimbriae-Mediated Bacterial Adhesion

(2011) Mirja Hartmann et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Pharmacological chaperone therapy for Gaucher disease: a patent review

(2011) Juan M Benito et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Jack bean α-mannosidase (Jbα-man): Tolerance to alkali, chelating and reducing agents and energetics of catalysis and inhibition

(2011) Avinash Kumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Pharmacological therapy for cystic fibrosis: From bench to bedside

(2011) Frédéric Becq et al.   Journal of Cystic Fibrosis

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

(2010) Elena M. Sánchez-Fernández et al.   CHEMICAL COMMUNICATIONS

Attaching Zanamivir to a Polymer Markedly Enhances Its Activity Against Drug-resistant Strains of Influenza a Virus

(2010) Alisha K. Weight et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A Cystic Fibrosis Respiratory Epithelial Cell Chronically Treated by Miglustat Acquires a Non–Cystic Fibrosis–Like Phenotype

(2009) Caroline Norez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions

(2009) Narayanaswamy Jayaraman   CHEMICAL SOCIETY REVIEWS

A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60

(2009) Julien Iehl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Inhibitors Against Glycosidases as Medicines

(2009) Tetsuya Kajimoto et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

(2009) Giancarlo Parenti   EMBO Molecular Medicine

Synergistic Effect of Zanamivir−Porphyrin Conjugates on Inhibition of Neuraminidase and Inactivation of Influenza Virus

(2009) Wen-Hsien Wen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosidase inhibition: assessing mimicry of the transition state

(2009) Tracey M. Gloster et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Generalized Anomeric Effect ingem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics

(2009) Elena M. Sánchez-Fernández et al.   ORGANIC LETTERS

Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism

(2009) Tom Wennekes et al.   TETRAHEDRON-ASYMMETRY

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic insights into glycosidase chemistry

(2008) David J Vocadlo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Covalent inhibitors of glycosidases and their applications in biochemistry and biology

(2008) B. P Rempel et al.   GLYCOBIOLOGY

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Golgi  -mannosidase II cleaves two sugars sequentially in the same catalytic site

(2008) N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A counterintuitive approach to treat enzyme deficiencies: use of enzyme inhibitors for restoring mutant enzyme activity

(2007) Jian-Qiang Fan   BIOLOGICAL CHEMISTRY