Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

Bicyclic Derivatives ofL-Idonojirimycin as Pharmacological Chaperones for Neuronopathic Forms of Gaucher Disease

(2013) Pilar Alfonso et al.   CHEMBIOCHEM

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Recent developments in design and synthesis of bicyclic azasugars, carbasugars and related molecules as glycosidase inhibitors

(2013) Rima Lahiri et al.   CHEMICAL SOCIETY REVIEWS

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate–protein interactions

(2013) Álvaro Martínez et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycocalixarenes for recognition of biological macromolecules: glycocalyx mimics capable of multitasking

(2013) Francesco Sansone et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

(2013) Yoann M. Chabre et al.   CHEMICAL SOCIETY REVIEWS

Recent progress and challenges in the discovery of new neuraminidase inhibitors

(2013) Supakarn Chamni et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A Bicyclic 1-Deoxygalactonojirimycin Derivative as a Novel Pharmacological Chaperone for GM1 Gangliosidosis

(2013) Tomoko Takai et al.   MOLECULAR THERAPY

Synthesis and Biophysical Study of Disassembling Nanohybrid Bioconjugates with a Cubic Octasilsesquioxane Core

(2012) Beatriz Trastoy et al.   ADVANCED FUNCTIONAL MATERIALS

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Carbosilane glycodendrimers

(2012) Ken Hatano et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies

(2012) José L. Jiménez Blanco et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glyco(cyclo)peptides

(2012) M. Carmen Galan et al.   CHEMICAL SOCIETY REVIEWS

Sweet carbon nanostructures: carbohydrate conjugates with carbon nanotubes and graphene and their applications

(2012) Yanan Chen et al.   CHEMICAL SOCIETY REVIEWS

sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of α-Linked Disaccharides; Implications for Glycosidase Inhibition

(2012) Elena M. Sánchez-Fernández et al.   CHEMISTRY-A EUROPEAN JOURNAL

How the Generalized Anomeric Effect Influences the Conformational Preference

(2012) Changwei Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in Neuraminidase Inhibitor Development as Anti-influenza Drugs

(2012) Enguang Feng et al.   ChemMedChem

Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds

(2012) Gustavo Tiscornia et al.   HUMAN MOLECULAR GENETICS

The Chemistry–Glycobiology Frontier

(2012) Barbara Imperiali   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

(2012) Tracey M Gloster et al.   Nature Chemical Biology

Conformational Analyses of the Reaction Coordinate of Glycosidases

(2011) Gideon J. Davies et al.   ACCOUNTS OF CHEMICAL RESEARCH

Optimization of the enzyme-linked lectin assay for enhanced glycoprotein and glycoconjugate analysis

(2011) Roisin Thompson et al.   ANALYTICAL BIOCHEMISTRY

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Dodecavalent Fullerene-Based Glycoclusters and Evaluation of Their Binding Properties towards a Bacterial Lectin

(2011) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Jack bean α-mannosidase (Jbα-man): Tolerance to alkali, chelating and reducing agents and energetics of catalysis and inhibition

(2011) Avinash Kumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Probing Carbohydrate-Lectin Recognition in Heterogeneous Environments with Monodisperse Cyclodextrin-Based Glycoclusters

(2011) Marta Gómez-García et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-catalyzed alkyne-azide cycloaddition for the functionalization of fullerene building blocks

(2011) Jean-François Nierengarten   PURE AND APPLIED CHEMISTRY

The C-Terminal Domain of the Arabinosyltransferase Mycobacterium tuberculosis EmbC Is a Lectin-Like Carbohydrate Binding Module

(2011) Luke J. Alderwick et al.   PLoS Pathogens

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

(2010) Elena M. Sánchez-Fernández et al.   CHEMICAL COMMUNICATIONS

The functional valency of dodecamannosylated fullerenes with Escherichia coli FimH—towards novel bacterial antiadhesives

(2010) Maxime Durka et al.   CHEMICAL COMMUNICATIONS

Iminosugars past, present and future: medicines for tomorrow

(2010) Graeme Horne et al.   DRUG DISCOVERY TODAY

Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose

(2010) Keizo Yamamoto et al.   FEBS Journal

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Carbohydrate-binding domains: multiplicity of biological roles

(2009) Daniel Guillén et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effects of pH and Iminosugar Pharmacological Chaperones on Lysosomal Glycosidase Structure and Stability

(2009) Raquel L. Lieberman et al.   BIOCHEMISTRY

Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions

(2009) Narayanaswamy Jayaraman   CHEMICAL SOCIETY REVIEWS

A Click-Click Approach for the Preparation of Functionalized [5:1]-Hexaadducts of C60

(2009) Julien Iehl et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Mechanism of Human α-Galactosidase

(2009) Abigail I. Guce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complex genetic regulation of proteinglycosylation

(2009) Gordan Lauc et al.   Molecular BioSystems

Generalized Anomeric Effect ingem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics

(2009) Elena M. Sánchez-Fernández et al.   ORGANIC LETTERS

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Golgi  -mannosidase II cleaves two sugars sequentially in the same catalytic site

(2008) N. Shah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding mode analyses and pharmacophore model development for sulfonamide chalcone derivatives, a new class of α-glucosidase inhibitors

(2007) Kavitha Bharatham et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING