Synthesis and biological properties of multivalent iminosugars

Octopus glycosides: multivalent molecular platforms for testing carbohydrate recognition and bacterial adhesion

(2015) Thisbe K. Lindhorst et al.   CARBOHYDRATE RESEARCH

Investigation of the copper(i) catalysed azide–alkyne cycloaddition reactions (CuAAC) in molten PEG2000

(2015) Isabelle Billault et al.   NEW JOURNAL OF CHEMISTRY

Synthesis of the first examples of iminosugar clusters based on cyclopeptoid cores

(2014) Mathieu L Lepage et al.   Beilstein Journal of Organic Chemistry

The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience

(2014) Philippe Compain et al.   CHEMBIOCHEM

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

(2014) Colin Bonduelle et al.   CHEMICAL COMMUNICATIONS

Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept

(2014) Sébastien G. Gouin   CHEMISTRY-A EUROPEAN JOURNAL

A Convergent Strategy for the Synthesis of Second-Generation Iminosugar Clusters Using “Clickable” Trivalent Dendrons

(2014) Antoine Joosten et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The development and use of small molecule inhibitors of glycosphingolipid metabolism for lysosomal storage diseases

(2014) James A. Shayman et al.   JOURNAL OF LIPID RESEARCH

Thiol-ene and thiol-yne-based synthesis of glycodendrimers as nanomolar inhibitors of wheat germ agglutinin

(2014) Mattia Ghirardello et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

6-Azido hyacinthacine A2gives a straightforward access to the first multivalent pyrrolizidine architectures

(2014) Giampiero D'Adamio et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Searching for Glycomimetics That Target Protein Misfolding in Rare Diseases: Successes, Failures, and Unexpected Progress Made in Organic Synthesis

(2014) Philippe Compain   SYNLETT

Synthesis and glycosidase inhibition properties of triazole-linked calixarene–iminosugar clusters

(2014) Alberto Marra et al.   TETRAHEDRON

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

(2013) Antoine Joosten et al.   CHEMBIOCHEM

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin-Based Iminosugar Click Clusters

(2013) Camille Decroocq et al.   CHEMBIOCHEM

Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors

(2013) Philippe Compain et al.   CHEMBIOCHEM

Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors

(2013) Jean-Louis Reymond et al.   CHEMICAL SOCIETY REVIEWS

Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

(2013) Yoann M. Chabre et al.   CHEMICAL SOCIETY REVIEWS

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxime Ligation: A Chemoselective Click-Type Reaction for Accessing Multifunctional Biomolecular Constructs

(2013) Sébastien Ulrich et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploring a Multivalent Approach to α-L-Fucosidase Inhibition

(2013) Elena Moreno-Clavijo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetravalent glycocyclopeptide with nanomolar affinity to wheat germ agglutinin

(2013) Michele Fiore et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Low-generation dendrimers with a calixarene core and based on a chiralC2-symmetric pyrrolidine as iminosugar mimics

(2012) Marco Marradi et al.   Beilstein Journal of Organic Chemistry

A Historical Perspective for the Catalytic Reaction Mechanism of Glycosidase; So As to Bring about Breakthrough in Confusing Situation

(2012) Seiya CHIBA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies

(2012) José L. Jiménez Blanco et al.   CHEMICAL SOCIETY REVIEWS

sp2-Iminosugar O-, S-, and N-Glycosides as Conformational Mimics of α-Linked Disaccharides; Implications for Glycosidase Inhibition

(2012) Elena M. Sánchez-Fernández et al.   CHEMISTRY-A EUROPEAN JOURNAL

Building Multivalent Iminosugar-Based Ligands on Calixarene Cores via Nitrone Cycloadditions

(2012) Francesca Cardona et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent applications of thiol–ene coupling as a click process for glycoconjugation

(2011) Alessandro Dondoni et al.   CHEMICAL SOCIETY REVIEWS

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Combining Glycomimetic and Multivalent Strategies toward Designing Potent Bacterial Lectin Inhibitors

(2011) Yoann M. Chabre et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Azide-armed α-1-C-Alkyl-imino-d-xylitol Derivatives as Key Building Blocks for the Preparation of Iminosugar Click Conjugates

(2011) Camille Decroocq et al.   JOURNAL OF CARBOHYDRATE CHEMISTRY

Exhaustive glycosylation, pegylation, and glutathionylation of a [G4]-ene48 dendrimer via photoinduced thiol-ene coupling

(2011) Mauro Lo Conte et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Biologically Active Polymersomes from Amphiphilic Glycopeptides

(2011) Jin Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

(2011) Nicolas Ardes-Guisot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and inhibitory activities of novel C-3 substituted azafagomines: A new type of selective inhibitors of α-l-fucosidases

(2010) Elena Moreno-Clavijo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of new β-1-C-alkylated imino-l-iditols: A comparative study of their activity as β-glucocerebrosidase inhibitors

(2010) Wojciech Schönemann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fullerene sugar balls

(2010) Jean-François Nierengarten et al.   CHEMICAL COMMUNICATIONS

Calixarene and Calixresorcarene Glycosides: Their Synthesis and Biological Applications

(2010) Alessandro Dondoni et al.   CHEMICAL REVIEWS

Biomedical applications of dendrimers: a tutorial

(2010) Meredith A. Mintzer et al.   CHEMICAL SOCIETY REVIEWS

Iminosugars past, present and future: medicines for tomorrow

(2010) Graeme Horne et al.   DRUG DISCOVERY TODAY

Synthesis, Biological Evaluation and Docking Studies of Casuarine Analogues: Effects of Structural Modifications at Ring B on Inhibitory Activity Towards Glucoamylase

(2010) Claudia Bonaccini et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Strain-Promoted Alkyne Azide Cycloaddition for the Functionalization of Poly(amide)-Based Dendrons and Dendrimers

(2010) Cátia Ornelas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multivalent ligand presentation as a central concept to study intricate carbohydrate–protein interactions

(2009) Narayanaswamy Jayaraman   CHEMICAL SOCIETY REVIEWS

Glycomimetics at the Mirror: Medicinal Chemistry of L-Iminosugars

(2009) Daniele D'Alonzo et al.   CURRENT MEDICINAL CHEMISTRY

Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation

(2009) Tom Wennekes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Generalized Anomeric Effect ingem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics

(2009) Elena M. Sánchez-Fernández et al.   ORGANIC LETTERS

Tactics and strategies for the synthesis of iminosugar C-glycosides: a review

(2009) Philippe Compain et al.   TETRAHEDRON-ASYMMETRY

Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism

(2009) Tom Wennekes et al.   TETRAHEDRON-ASYMMETRY

Iminosugars: from botanical curiosities to licensed drugs

(2009) Bryan G. Winchester   TETRAHEDRON-ASYMMETRY

Synthesis of sialoclusters appended to calix[4]arene platforms via multiple azide-alkyne cycloaddition. New inhibitors of hemagglutination and cytopathic effect mediated by BK and influenza A viruses

(2008) Alberto Marra et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Large-Scale Synthesis of the Glucosylceramide Synthase InhibitorN-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin

(2008) Tom Wennekes et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT