Multivalent Inhibitors for Carbohydrate-Processing Enzymes: Beyond the “Lock-and-Key” Concept

Avidity Modulation of Folate-Targeted Multivalent Dendrimers for Evaluating Biophysical Models of Cancer Targeting Nanoparticles

(2013) Justin E. Silpe et al.   ACS Chemical Biology

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

(2013) Antoine Joosten et al.   CHEMBIOCHEM

Rescue of Functional CFTR Channels in Cystic Fibrosis: A Dramatic Multivalent Effect Using Iminosugar Cluster-Based Correctors

(2013) Philippe Compain et al.   CHEMBIOCHEM

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate–protein interactions

(2013) Álvaro Martínez et al.   CHEMICAL SOCIETY REVIEWS

Fullerene-sp2-Iminosugar Balls as Multimodal Ligands for Lectins and Glycosidases: A Mechanistic Hypothesis for the Inhibitory Multivalent Effect

(2013) Rocío Rísquez-Cuadro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Exploring a Multivalent Approach to α-L-Fucosidase Inhibition

(2013) Elena Moreno-Clavijo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Topological Effects and Binding Modes Operating with Multivalent Iminosugar-Based Glycoclusters and Mannosidases

(2013) Yoan Brissonnet et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclodextrin-Based Iminosugar Click Clusters: The First Examples of Multivalent Pharmacological Chaperones for the Treatment of Lysosomal Storage Disorders

(2012) Camille Decroocq et al.   CHEMBIOCHEM

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin

(2012) Mehdi Almant et al.   CHEMISTRY-A EUROPEAN JOURNAL

Accelerated Enzymatic Galactosylation of N-Acetylglucosaminolipids in Lipid Microdomains

(2012) Gavin T. Noble et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Inhibition of Liposaccharide Heptosyltransferase WaaC with Multivalent Glycosylated Fullerenes: A New Mode of Glycosyltransferase Inhibition

(2011) Maxime Durka et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

(2011) Camille Decroocq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Clustering of Escherichia coli Type-1 Fimbrial Adhesins by Using Multimeric Heptyl α-D-Mannoside Probes with a Carbohydrate Core

(2011) Mehdi Almant et al.   CHEMISTRY-A EUROPEAN JOURNAL

Secondary substrate binding strongly affects activity and binding affinity ofBacillus subtilisandAspergillus nigerGH11 xylanases

(2011) Sven Cuyvers et al.   FEBS Journal

Jack bean α-mannosidase (Jbα-man): Tolerance to alkali, chelating and reducing agents and energetics of catalysis and inhibition

(2011) Avinash Kumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Synthesis of Multivalent Glycoclusters from 1-Thio-β-d-galactose and Their Inhibitory Activity against the β-Galactosidase fromE. coli

(2011) Alejandro J. Cagnoni et al.   JOURNAL OF ORGANIC CHEMISTRY

Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells

(2011) Jennifer D. Diot et al.   JOURNAL OF ORGANIC CHEMISTRY

Dependence of Avidity on Linker Length for a Bivalent Ligand–Bivalent Receptor Model System

(2011) Eric T. Mack et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glycosidase Inhibition with Fullerene Iminosugar Balls: A Dramatic Multivalent Effect

(2010) Philippe Compain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Calixarene and Calixresorcarene Glycosides: Their Synthesis and Biological Applications

(2010) Alessandro Dondoni et al.   CHEMICAL REVIEWS

Insights in the rational design of synthetic multivalent glycoconjugates as lectin ligands

(2010) David Deniaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Modulating glycosidase degradation and lectin recognition of gold glyconanoparticles

(2009) Africa G. Barrientos et al.   CARBOHYDRATE RESEARCH

Synthetic Multimeric Heptyl Mannosides as Potent Antiadhesives of UropathogenicEscherichia coli

(2009) Sébastien G. Gouin et al.   ChemMedChem

Maximising multivalency effects in protein–carbohydrate interactions

(2009) Roland J. Pieters   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism

(2009) Tom Wennekes et al.   TETRAHEDRON-ASYMMETRY

Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins

(2008) Anne Imberty et al.   CHEMISTRY-A EUROPEAN JOURNAL

Probing multivalency for the inhibition of an enzyme: glycogen phosphorylase as a case study

(2008) Samy Cecioni et al.   NEW JOURNAL OF CHEMISTRY

Multivalent iminosugars to modulate affinity and selectivity for glycosidases

(2008) Jennifer Diot et al.   ORGANIC & BIOMOLECULAR CHEMISTRY