Optogenetically controlled protein kinases for regulation of cellular signaling

Near-infrared optogenetic pair for protein regulation and spectral multiplexing

(2017) Taras A Redchuk et al.   Nature Chemical Biology

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor

(2017) Hideji Murakoshi et al.   NEURON

Optical control of cell signaling by single-chain photoswitchable kinases

(2017) Xin X. Zhou et al.   SCIENCE

Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons

(2017) Valentina Latina et al.   Frontiers in Cellular Neuroscience

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

(2017) Raquel M. Melero-Fernandez de Mera et al.   Nature Communications

Dynamics of p53: A Master Decider of Cell Fate

(2017) Qingyin Luo et al.   Genes

How to Train a Cell–Cutting-Edge Molecular Tools

(2017) Jakub Czapiński et al.   Frontiers in Chemistry

A Phytochrome Sensory Domain Permits Receptor Activation by Red Light

(2016) Eva Reichhart et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression

(2016) Gembu Maryu et al.   CELL STRUCTURE AND FUNCTION

Reversible optogenetic control of kinase activity during differentiation and embryonic development

(2016) Vishnu V. Krishnamurthy et al.   DEVELOPMENT

Optogenetic activation reveals distinct roles of PIP3and Akt in adipocyte insulin action

(2016) Yingke Xu et al.   JOURNAL OF CELL SCIENCE

Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism

(2016) Lisandro Horacio Otero et al.   JOURNAL OF MOLECULAR BIOLOGY

A bacterial phytochrome-based optogenetic system controllable with near-infrared light

(2016) Andrii A Kaberniuk et al.   NATURE METHODS

Optogenetic toolkit reveals the role of Ca2+sparklets in coordinated cell migration

(2016) Jin Man Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering extrinsic disorder to control protein activity in living cells

(2016) Onur Dagliyan et al.   SCIENCE

Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors

(2016) Claire V. Chatelle et al.   Scientific Reports

Blue light-induced LOV domain dimerization enhances the affinity of Aureochrome 1a for its target DNA sequence

(2016) Udo Heintz et al.   eLife

Arrays of microscopic organic LEDs for high-resolution optogenetics

(2016) A. Steude et al.   Science Advances

The Timing of Raf/ERK and AKT Activation in Protecting PC12 Cells against Oxidative Stress

(2016) Qunxiang Ong et al.   PLoS One

Fiberless multicolor neural optoelectrode for in vivo circuit analysis

(2016) Komal Kampasi et al.   Scientific Reports

An open-hardware platform for optogenetics and photobiology

(2016) Karl P. Gerhardt et al.   Scientific Reports

Natural Photoreceptors as a Source of Fluorescent Proteins, Biosensors, and Optogenetic Tools

(2015) Daria M. Shcherbakova et al.   Annual Review of Biochemistry

Activation of transmembrane cell-surface receptors via a common mechanism? The “rotation model”

(2015) Ichiro N. Maruyama   BIOESSAYS

Light-induced Changes in the Dimerization Interface of Bacteriophytochromes

(2015) Heikki Takala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Optical techniques in optogenetics

(2015) Samarendra K. Mohanty et al.   JOURNAL OF MODERN OPTICS

All-Optical Interrogation of Neural Circuits

(2015) V. Emiliani et al.   JOURNAL OF NEUROSCIENCE

Frequency modulation of ERK activation dynamics rewires cell fate

(2015) H. Ryu et al.   Molecular Systems Biology

Structural basis for gene regulation by a B12-dependent photoreceptor

(2015) Marco Jost et al.   NATURE

Light-assisted small-molecule screening against protein kinases

(2015) Álvaro Inglés-Prieto et al.   Nature Chemical Biology

Wirelessly powered, fully internal optogenetics for brain, spinal and peripheral circuits in mice

(2015) Kate L Montgomery et al.   NATURE METHODS

Optogenetics: 10 years of microbial opsins in neuroscience

(2015) Karl Deisseroth   NATURE NEUROSCIENCE

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering

(2015) L. J. Bugaj et al.   Nature Communications

Oscillation of p38 activity controls efficient pro-inflammatory gene expression

(2015) Taichiro Tomida et al.   Nature Communications

An optogenetic system for interrogating the temporal dynamics of Akt

(2015) Yoshihiro Katsura et al.   Scientific Reports

Scattering of Sculpted Light in Intact Brain Tissue, with implications for Optogenetics

(2015) Itia A. Favre-Bulle et al.   Scientific Reports

Evolution of optogenetic microdevices

(2015) Rajas P. Kale et al.   Neurophotonics

Spatiotemporal Control of Fibroblast Growth Factor Receptor Signals by Blue Light

(2014) Nury Kim et al.   CHEMISTRY & BIOLOGY

Spatio-temporally precise activation of engineered receptor tyrosine kinases by light

(2014) M. Grusch et al.   EMBO JOURNAL

Small Molecule Gated Split-Tyrosine Phosphatases and Orthogonal Split-Tyrosine Kinases

(2014) Karla Camacho-Soto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Capable ABL: What Is Its Biological Function?

(2014) J. Y. J. Wang   MOLECULAR AND CELLULAR BIOLOGY

Signal amplification and transduction in phytochrome photosensors

(2014) Heikki Takala et al.   NATURE

Photochemistry of flavoprotein light sensors

(2014) Karen S Conrad et al.   Nature Chemical Biology

Reversible protein inactivation by optogenetic trapping in cells

(2014) Sangkyu Lee et al.   NATURE METHODS

Characterizing bacterial gene circuit dynamics with optically programmed gene expression signals

(2014) Evan J Olson et al.   NATURE METHODS

Nuclear and cytosolic JNK signalling in neurons

(2014) Eleanor T. Coffey   NATURE REVIEWS NEUROSCIENCE

Light-Mediated Kinetic Control Reveals the Temporal Effect of the Raf/MEK/ERK Pathway in PC12 Cell Neurite Outgrowth

(2014) Kai Zhang et al.   PLoS One

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulation of Endogenous Kinase Activity in Living Cells Using Photoswitchable Inhibitory Peptides

(2014) Jason J. Yi et al.   ACS Synthetic Biology

Benchmarking of Optical Dimerizer Systems

(2014) Gopal P. Pathak et al.   ACS Synthetic Biology

Cyclin-dependent kinases

(2014) Marcos Malumbres   GENOME BIOLOGY

PIF-Pocket as a Target for C. albicans Pkh Selective Inhibitors

(2013) Daniel Pastor-Flores et al.   ACS Chemical Biology

PKA: Lessons learned after twenty years

(2013) Susan S. Taylor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Using Optogenetics to Interrogate the Dynamic Control of Signal Transmission by the Ras/Erk Module

(2013) Jared E. Toettcher et al.   CELL

Engineering of bacterial phytochromes for near-infrared imaging, sensing, and light-control in mammals

(2013) Kiryl D. Piatkevich et al.   CHEMICAL SOCIETY REVIEWS

Optogenetic protein clustering and signaling activation in mammalian cells

(2013) Lukasz J Bugaj et al.   NATURE METHODS

Manipulating signaling at will: chemically-inducible dimerization (CID) techniques resolve problems in cell biology

(2013) Robert DeRose et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Rational design of a ligand-controlled protein conformational switch

(2013) O. Dagliyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic Control of Protein Kinase Activity in Mammalian Cells

(2013) Sabrina Wend et al.   ACS Synthetic Biology

The Protein Interaction Landscape of the Human CMGC Kinase Group

(2013) Markku Varjosalo et al.   Cell Reports

The Structural Basis for Control of Eukaryotic Protein Kinases

(2012) Jane A. Endicott et al.   Annual Review of Biochemistry

Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway

(2012) Hiroyuki Kubota et al.   MOLECULAR CELL

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device

(2012) Peixin Zhu et al.   Nature Protocols

JAK/STAT: The Enigma within the Mystery of NMDAR-LTD

(2012) Todd C. Sacktor   NEURON

The JAK/STAT Pathway Is Involved in Synaptic Plasticity

(2012) Céline S. Nicolas et al.   NEURON

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Design principles underpinning the regulatory diversity of protein kinases

(2012) K. Oruganty et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Optogenetic control of phosphoinositide metabolism

(2012) O. Idevall-Hagren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical Control of Protein Activity by Fluorescent Protein Domains

(2012) X. X. Zhou et al.   SCIENCE

Spatially directed guidance of stem cell population migration by immobilized patterns of growth factors

(2011) Eric D. Miller et al.   BIOMATERIALS

Bacterial phytochromes: More than meets the light

(2011) Michele E. Auldridge et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulation of protein kinases by lipids

(2011) Thomas A Leonard et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Light-based feedback for controlling intracellular signaling dynamics

(2011) Jared E Toettcher et al.   NATURE METHODS

Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins

(2011) Joanna Mattis et al.   NATURE METHODS

Imaging the coordination of multiple signalling activities in living cells

(2011) Christopher M. Welch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of a Light-Activated LOV Protein Dimer That Regulates Transcription

(2011) A. T. Vaidya et al.   Science Signaling

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Morphogen gradients in development: from form to function

(2011) Jan L. Christian   Wiley Interdisciplinary Reviews-Developmental Biology

Structure and Function of Plant Photoreceptors

(2010) Andreas Möglich et al.   Annual Review of Plant Biology

Tripping the Light Fantastic: Blue-Light Photoreceptors as Examples of Environmentally Modulated Protein−Protein Interactions

(2010) Brian D. Zoltowski et al.   BIOCHEMISTRY

A Brief History of Phytochromes

(2010) Nathan C. Rockwell et al.   CHEMPHYSCHEM

Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP

(2010) Andrei V. Karginov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineered allosteric activation of kinases in living cells

(2010) Andrei V Karginov et al.   NATURE BIOTECHNOLOGY

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Rationally improving LOV domain–based photoswitches

(2010) Devin Strickland et al.   NATURE METHODS

Engineered photoreceptors as novel optogenetic tools

(2010) Andreas Möglich et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Receptor tyrosine kinase transmembrane domains

(2010) Edwin Li et al.   Cell Adhesion & Migration

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

(2009) Colin W. Ward et al.   BIOESSAYS

Microfluidics as a functional tool for cell mechanics

(2009) Siva A. Vanapalli et al.   Biomicrofluidics

Amitriptyline is a TrkA and TrkB Receptor Agonist that Promotes TrkA/TrkB Heterodimerization and Has Potent Neurotrophic Activity

(2009) Sung-Wuk Jang et al.   CHEMISTRY & BIOLOGY

Identification of N-Terminal Lobe Motifs that Determine the Kinase Activity of the Catalytic Domains and Regulatory Strategies of Src and Csk Protein Tyrosine Kinases

(2009) Kezhen Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

Cell Type-Specific Importance of Ras-c-Raf Complex Association Rate Constants for MAPK Signaling

(2009) C. Kiel et al.   Science Signaling

Structure and Signaling Mechanism of Per-ARNT-Sim Domains

(2009) Andreas Möglich et al.   STRUCTURE

Light-Mediated Liberation of Enzymatic Activity: “Small Molecule” Caged Protein Equivalents

(2008) Haishan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacteriophytochromes in anoxygenic photosynthetic bacteria

(2008) Eric Giraud et al.   PHOTOSYNTHESIS RESEARCH

Light-dependent regulation of structural flexibility in a photochromic fluorescent protein

(2008) H. Mizuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of Pseudomonas aeruginosa bacteriophytochrome: Photoconversion and signal transduction

(2008) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA