Activation of transmembrane cell-surface receptors via a common mechanism? The “rotation model”

Insulin/receptor binding: The last piece of the puzzle?

(2015) Pierre De Meyts   BIOESSAYS

The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition

(2015) Christoph Garbers et al.   CURRENT OPINION IN IMMUNOLOGY

Dimerization of the EphA1 Receptor Tyrosine Kinase Transmembrane Domain: Insights into the Mechanism of Receptor Activation

(2014) Matthieu Chavent et al.   BIOCHEMISTRY

Targeting thecis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling

(2014) L Cobret et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation and dysregulation of tumor necrosis factor receptor-1

(2014) Leen Puimège et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Insulin Receptor Activation with Transmembrane Domain Ligands

(2014) Jongsoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Point Mutations in Dimerization Motifs of the Transmembrane Domain Stabilize Active or Inactive State of the EphA2 Receptor Tyrosine Kinase

(2014) George V. Sharonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

20 YEARS OF LEPTIN: Insights into signaling assemblies of the leptin receptor

(2014) Frank Peelman et al.   JOURNAL OF ENDOCRINOLOGY

Axial helix rotation as a mechanism for signal regulation inferred from the crystallographic analysis of the E. coli serine chemoreceptor

(2014) Hedda U. Ferris et al.   JOURNAL OF STRUCTURAL BIOLOGY

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

(2014) A. J. Brooks et al.   SCIENCE

Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation

(2014) Sandro Manni et al.   STRUCTURE

Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases

(2014) Nicholas F. Endres et al.   TRENDS IN BIOCHEMICAL SCIENCES

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

How IGF-1 activates its receptor

(2014) Jennifer M Kavran et al.   eLife

Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers

(2014) Ichiro Maruyama   Cells

The insulin receptor changes conformation in unforeseen ways on ligand binding: Sharpening the picture of insulin receptor activation

(2013) Colin W. Ward et al.   BIOESSAYS

FGFR3 Transmembrane Domain Interactions Persist in the Presence of Its Extracellular Domain

(2013) Sarvenaz Sarabipour et al.   BIOPHYSICAL JOURNAL

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Environmental Alkalinity Sensing Mediated by the Transmembrane Guanylyl Cyclase GCY-14 in C. elegans

(2013) Takashi Murayama et al.   CURRENT BIOLOGY

Dynamic Analysis of the Epidermal Growth Factor (EGF) Receptor-ErbB2-ErbB3 Protein Network by Luciferase Fragment Complementation Imaging

(2013) Jennifer L. Macdonald-Obermann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How insulin engages its primary binding site on the insulin receptor

(2013) John G. Menting et al.   NATURE

Structural Analysis of Supramolecular Assemblies by Cryo-Electron Tomography

(2013) Jan Harapin et al.   STRUCTURE

Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells

(2013) Marina S Dietz et al.   BMC Biophysics

Insulin Receptor-Related Receptor as an Extracellular Alkali Sensor

(2011) Igor E. Deyev et al.   Cell Metabolism

Thrombopoietin receptor activation: transmembrane helix dimerization, rotation, and allosteric modulation

(2011) Erin E. Matthews et al.   FASEB JOURNAL

Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging

(2011) J. L. Macdonald-Obermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eph/ephrin signaling: Genetic, phosphoproteomic, and transcriptomic approaches

(2011) Jeffrey O. Bush et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Role of Juxtamembrane and Transmembrane Domains in the Mechanism of Natriuretic Peptide Receptor A Activation

(2010) Marie Parat et al.   BIOCHEMISTRY

Left-Handed Dimer of EphA2 Transmembrane Domain: Helix Packing Diversity among Receptor Tyrosine Kinases

(2010) Eduard V. Bocharov et al.   BIOPHYSICAL JOURNAL

Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells

(2010) Jianying Shen et al.   FEBS LETTERS

Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor

(2010) C. Lu et al.   MOLECULAR AND CELLULAR BIOLOGY

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

(2010) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

(2010) B. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of Eph receptor clusters

(2010) J. P. Himanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Homo-FRET Imaging Enables Quantification of Protein Cluster Sizes with Subcellular Resolution

(2009) Arjen N. Bader et al.   BIOPHYSICAL JOURNAL

Luciferase Fragment Complementation Imaging of Conformational Changes in the Epidermal Growth Factor Receptor

(2009) Katherine S. Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of Ectodomains of the Insulin Receptor Family: The Ectodomain of the Type 1 Insulin-Like Growth Factor Receptor Displays Asymmetry of Ligand Binding Accompanied by Limited Conformational Change

(2009) Andrew E. Whitten et al.   JOURNAL OF MOLECULAR BIOLOGY

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

(2009) Marçal Vilar et al.   NEURON

Turning the growth hormone receptor on: Evidence that hormone binding induces subunit rotation

(2009) David Poger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1

(2008) Eduard V. Bocharov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

(2008) R.-H. Tao et al.   JOURNAL OF CELL SCIENCE

A Comparative Structural Bioinformatics Analysis of the Insulin Receptor Family Ectodomain Based on Phylogenetic Information

(2008) Miguel E. Rentería et al.   PLoS One

Growth hormone receptor; mechanism of action

(2007) Andrew J. Brooks et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY