P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

Embryonic signaling in melanoma: potential for diagnosis and therapy

(2011) Luigi Strizzi et al.   LABORATORY INVESTIGATION

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion and metastasis

(2011) E K Kim et al.   ONCOGENE

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

Translating cancer research into targeted therapeutics

(2010) J. S. de Bono et al.   NATURE

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Melanoma — An Unlikely Poster Child for Personalized Cancer Therapy

(2010) Keiran S.M. Smalley et al.   NEW ENGLAND JOURNAL OF MEDICINE

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer

(2010) J C Montero et al.   ONCOGENE

Integrative Genome Comparison of Primary and Metastatic Melanomas

(2010) Omar Kabbarah et al.   PLoS One

Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system

(2009) Heidi V. N. Küsters-Vandevelde et al.   ACTA NEUROPATHOLOGICA

Melanocytes in development and cancer

(2009) Audrey Uong et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Understanding Melanoma Signaling Networks as the Basis for Molecular Targeted Therapy

(2009) Keiran S.M. Smalley   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

(2009) J Qin et al.   ONCOGENE

Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division

(2008) David Michaelson et al.   JOURNAL OF CELL BIOLOGY