Efferocytosis and Outside-In Signaling by Cardiac Phagocytes. Links to Repair, Cellular Programming, and Intercellular Crosstalk in Heart

Myeloid receptor CD36 is required for early phagocytosis of myocardial infarcts and induction of Nr4a1-dependent mechanisms of cardiac repair

(2018) Shirley Dehn et al.   FASEB JOURNAL

Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size

(2017) Annika Warnatsch et al.   IMMUNITY

Targeting and modulating infarct macrophages with hemin formulated in designed lipid-based particles improves cardiac remodeling and function

(2017) Tamar Ben-Mordechai et al.   JOURNAL OF CONTROLLED RELEASE

Phagocytosis imprints heterogeneity in tissue-resident macrophages

(2017) Noelia A-Gonzalez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA

(2017) Christian Lood et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The mitochondrial respiratory chain is essential for haematopoietic stem cell function

(2017) Elena Ansó et al.   NATURE CELL BIOLOGY

A heart–brain–kidney network controls adaptation to cardiac stress through tissue macrophage activation

(2017) Katsuhito Fujiu et al.   NATURE MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells

(2017) Lidia Bosurgi et al.   SCIENCE

Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis

(2017) Lucy E. Métayer et al.   Oncotarget

Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells

(2017) Bo Tian et al.   Scientific Reports

Myocardial Infarction Primes Autoreactive T Cells through Activation of Dendritic Cells

(2017) Katrien Van der Borght et al.   Cell Reports

Phosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis

(2017) Sefi Zargarian et al.   PLOS BIOLOGY

Canine Macrophage DH82 Cell Line As a Model to Study Susceptibility to Trypanosoma cruzi Infection

(2017) Pedro Henrique Braz Mendonça et al.   Frontiers in Immunology

Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension

(2016) Germán E. González et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens

(2016) S R Larson et al.   CELL DEATH AND DIFFERENTIATION

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth FactorCLINICAL PERSPECTIVE

(2016) Kiave-Yune Howangyin et al.   CIRCULATION

Selective Stimulation of Cardiac Lymphangiogenesis Reduces Myocardial Edema and Fibrosis Leading to Improved Cardiac Function Following Myocardial InfarctionCLINICAL PERSPECTIVE

(2016) Orianne Henri et al.   CIRCULATION

Primitive Embryonic Macrophages are Required for Coronary Development and MaturationNovelty and Significance

(2016) Jamison Leid et al.   CIRCULATION RESEARCH

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart FailureNovelty and Significance

(2016) Hendrik B. Sager et al.   CIRCULATION RESEARCH

Residual Myocardial Iron Following Intramyocardial Hemorrhage During the Convalescent Phase of Reperfused ST-Segment–Elevation Myocardial Infarction and Adverse Left Ventricular RemodelingCLINICAL PERSPECTIVE

(2016) Heerajnarain Bulluck et al.   Circulation-Cardiovascular Imaging

Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse RemodelingCLINICAL PERSPECTIVE

(2016) Avinash Kali et al.   Circulation-Cardiovascular Imaging

The time‐of‐day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment

(2016) Maximilian J Schloss et al.   EMBO Molecular Medicine

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

(2016) Michael Horckmans et al.   EUROPEAN HEART JOURNAL

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

(2016) Michio Nakaya et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages determine repair of the infarcted adult murine heart

(2016) Manabu Shiraishi et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis

(2016) Shirley Dehn et al.   JOURNAL OF IMMUNOLOGY

Treatment with anti-RANKL antibody reduces infarct size and attenuates dysfunction impacting on neutrophil-mediated injury

(2016) Federico Carbone et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

(2016) Claudia Z. Han et al.   NATURE

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

(2016) Johan Garaude et al.   NATURE IMMUNOLOGY

Fatty acid oxidation in macrophage polarization

(2016) Mitsunori Nomura et al.   NATURE IMMUNOLOGY

Cardiosphere-Derived Cells Facilitate Heart Repair by Modulating M1/M2 Macrophage Polarization and Neutrophil Recruitment

(2016) Al Shaimaa Hasan et al.   PLoS One

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes

(2016) Sahana Suresh Babu et al.   Scientific Reports

Intercellular Adhesion Molecule 1 Regulates Left Ventricular Leukocyte Infiltration, Cardiac Remodeling, and Function in Pressure Overload–Induced Heart Failure

(2016) Ane M. Salvador et al.   Journal of the American Heart Association

Lymphangiogenesis and Inflammation—Looking for the “Missing Pieces” of the Puzzle

(2015) Anca Maria Cimpean et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo

(2015) Michael P. Motley et al.   BLOOD

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Haptoglobin Enhances Cardiac Transplant Rejection

(2015) H. Shen et al.   CIRCULATION RESEARCH

Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in Patients With Acute Myocardial Infarction Based on Individual Patient Data

(2015) M. Gyongyosi et al.   CIRCULATION RESEARCH

CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac RemodelingCLINICAL PERSPECTIVE

(2015) Kristine Y. DeLeon-Pennell et al.   Circulation-Cardiovascular Genetics

The divergent roles of macrophages in solid organ transplantation

(2015) Sahar Salehi et al.   Current Opinion in Organ Transplantation

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance

(2015) Patricia Conde et al.   IMMUNITY

Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells

(2015) Emma L. Kuan et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function

(2015) Vasundhara Kain et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis

(2015) Shuang Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiac lymphatics are heterogeneous in origin and respond to injury

(2015) Linda Klotz et al.   NATURE

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Perioperative Myocardial Injury after Adult Heart Transplant: Determinants and Prognostic Value

(2015) Luca Salvatore De Santo et al.   PLoS One

ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis

(2015) M Yang et al.   Cell Death & Disease

CD36 Is a Matrix Metalloproteinase-9 Substrate That Stimulates Neutrophil Apoptosis and Removal During Cardiac RemodelingCLINICAL PERSPECTIVE

(2015) Kristine Y. DeLeon-Pennell et al.   Circulation-Cardiovascular Genetics

The transcription factor NR4A1 is essential for the development of a novel macrophage subset in the thymus

(2015) Robert Tacke et al.   Scientific Reports

Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis

(2014) Elke Marsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Class A scavenger receptor deficiency augments angiotensin II-induced vascular remodeling

(2014) Lingling Qian et al.   BIOCHEMICAL PHARMACOLOGY

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Ly-6C high Monocytes Depend on Nr4a1 to Balance Both Inflammatory and Reparative Phases in the Infarcted Myocardium

(2014) Ingo Hilgendorf et al.   CIRCULATION RESEARCH

Differential Contribution of Monocytes to Heart Macrophages in Steady-State and After Myocardial Infarction

(2014) Timo Heidt et al.   CIRCULATION RESEARCH

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

(2014) Peter Libby et al.   CIRCULATION RESEARCH

Interleukin-13 Deficiency Aggravates Healing and Remodeling in Male Mice After Experimental Myocardial Infarction

(2014) Ulrich Hofmann et al.   Circulation-Heart Failure

Macrophage HIF-2  Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity

(2014) S. S. Choe et al.   DIABETES

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

(2014) Slava Epelman et al.   IMMUNITY

Galectin-3 is essential for early wound healing and ventricular remodeling after myocardial infarction in mice

(2014) Germán E. González et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Selective apheresis of C-reactive protein: A new therapeutic option in myocardial infarction?

(2014) Ahmed Sheriff et al.   JOURNAL OF CLINICAL APHERESIS

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-self recognition by monocytes initiates allograft rejection

(2014) Martin H. Oberbarnscheidt et al.   JOURNAL OF CLINICAL INVESTIGATION

Progressive replacement of embryo-derived cardiac macrophages with age

(2014) Kaaweh Molawi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Alternative Macrophage Activation by Galectin-3

(2014) A. C. MacKinnon et al.   JOURNAL OF IMMUNOLOGY

Preemptive Donor Apoptotic Cell Infusions Induce IFN- -Producing Myeloid-Derived Suppressor Cells for Cardiac Allograft Protection

(2014) J. Bryant et al.   JOURNAL OF IMMUNOLOGY

Arginine Supplementation Induces Arginase Activity and Inhibits TNF-α Synthesis in Mice Spleen Macrophages After Intestinal Obstruction

(2014) Iara Eliza Pacífico Quirino et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart

(2014) Kory J. Lavine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function

(2014) Armand O. Brown et al.   PLoS Pathogens

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

(2013) Maulik D. Majmudar et al.   CIRCULATION

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction

(2013) Elaine Wan et al.   CIRCULATION RESEARCH

Macrophage ADAM17 Deficiency Augments CD36-Dependent Apoptotic Cell Uptake and the Linked Anti-Inflammatory Phenotype

(2013) Will S. Driscoll et al.   CIRCULATION RESEARCH

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis

(2013) Benjamin D. Humphreys et al.   JOURNAL OF CLINICAL INVESTIGATION

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

(2013) Sean P. Cullen et al.   MOLECULAR CELL

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion

(2013) Amelia E. Hochreiter-Hufford et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function

(2013) Anna Sokolovska et al.   NATURE IMMUNOLOGY

Tissue-resident macrophages

(2013) Luke C Davies et al.   NATURE IMMUNOLOGY

Long pentraxin PTX3 attenuates ischemia reperfusion injury in a cardiac transplantation model

(2013) Hongfei Zhu et al.   TRANSPLANT INTERNATIONAL

Myeloid Cells and Lymphangiogenesis

(2013) A. Zumsteg et al.   Cold Spring Harbor Perspectives in Medicine

Mitochondrial dynamics in the adult cardiomyocytes: which roles for a highly specialized cell?

(2013) Jerome Piquereau et al.   Frontiers in Physiology

Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation

(2012) Elena Dolmatova et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome

(2012) Suree Lekawanvijit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intragraft CD11b+IDO+Cells Mediate Cardiac Allograft Tolerance by ECDI-Fixed Donor Splenocyte Infusions

(2012) G. Chen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

SR-A deficiency reduces myocardial ischemia/reperfusion injury; involvement of increased microRNA-125b expression in macrophages

(2012) Danyang Ren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

Activation of CD4 + T Lymphocytes Improves Wound Healing and Survival After Experimental Myocardial Infarction in Mice

(2012) Ulrich Hofmann et al.   CIRCULATION

Interleukin-10 Treatment Attenuates Pressure Overload–Induced Hypertrophic Remodeling and Improves Heart Function via Signal Transducers and Activators of Transcription 3–Dependent Inhibition of Nuclear Factor-κB

(2012) Suresh Kumar Verma et al.   CIRCULATION

Neurohormonal Modulation of the Innate Immune System Is Proinflammatory in the Prehypertensive Spontaneously Hypertensive Rat, a Genetic Model of Essential Hypertension

(2012) Sailesh C. Harwani et al.   CIRCULATION RESEARCH

Regulation of the Inflammatory Response in Cardiac Repair

(2012) Nikolaos G. Frangogiannis   CIRCULATION RESEARCH

Erythrocyte-rich thrombus aspirated from patients with ST-elevation myocardial infarction: association with oxidative stress and its impact on myocardial reperfusion

(2012) Kei Yunoki et al.   EUROPEAN HEART JOURNAL

Purinergic P2Y2 Receptors Promote Neutrophil Infiltration and Hepatocyte Death in Mice With Acute Liver Injury

(2012) Cemil Korcan Ayata et al.   GASTROENTEROLOGY

Myeloid-derived suppressor cells in transplantation and cancer

(2012) Jordi C. Ochando et al.   IMMUNOLOGIC RESEARCH

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

(2012) Florian Leuschner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myocardial infarction accelerates atherosclerosis

(2012) Partha Dutta et al.   NATURE

Myocardial Infarction Triggers Chronic Cardiac Autoimmunity in Type 1 Diabetes

(2012) R. V. S. R. K. Gottumukkala et al.   Science Translational Medicine

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Cell Death, Damage-Associated Molecular Patterns, and Sterile Inflammation in Cardiovascular Disease

(2011) Yue Zheng et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Class A scavenger receptor attenuates myocardial infarction-induced cardiomyocyte necrosis through suppressing M1 macrophage subset polarization

(2011) Yulong Hu et al.   BASIC RESEARCH IN CARDIOLOGY

Maternal and Fetal Factors Associated With Mortality and Morbidity in a Multi–Racial/Ethnic Registry of Anti-SSA/Ro–Associated Cardiac Neonatal Lupus

(2011) Peter M. Izmirly et al.   CIRCULATION

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

(2011) Kodi S. Ravichandran   IMMUNITY

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)

(2011) Edward Thorp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 is a new MerTK-specific eat-me signal

(2011) Nora B. Caberoy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PTX3 Is Located at the Membrane of Late Apoptotic Macrophages and Mediates the Phagocytosis of Macrophages

(2011) Tangmeng Guo et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans

(2011) HuiJuan Lv et al.   JOURNAL OF CLINICAL INVESTIGATION

An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice

(2011) Anca Sindrilaru et al.   JOURNAL OF CLINICAL INVESTIGATION

Decreased efferocytosis and mannose binding lectin in the airway in bronchiolitis obliterans syndrome

(2011) Sandra Hodge et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Early cardiac morphogenesis defects caused by loss of embryonic macrophage function in Xenopus

(2011) Stuart J. Smith et al.   MECHANISMS OF DEVELOPMENT

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

(2011) Daeho Park et al.   NATURE

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair

(2011) Tamar Harel-Adar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Advances in transplantation

(2011) Megan Sykes et al.   SEMINARS IN IMMUNOLOGY

Modulation of Macrophage Efferocytosis in Inflammation

(2011) Darlynn Korns et al.   Frontiers in Immunology

Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction

(2010) Rudolf A. de Boer et al.   ANNALS OF MEDICINE

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Role of the Urokinase Plasminogen Activator Receptor in Mediating Impaired Efferocytosis of Anti-SSA/Ro–Bound Apoptotic Cardiocytes

(2010) Paraskevi Briassouli et al.   CIRCULATION RESEARCH

Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury

(2010) Haiyan Lu et al.   FASEB JOURNAL

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

The role of inflammatory and fibrogenic pathways in heart failure associated with aging

(2010) Wei Chen et al.   HEART FAILURE REVIEWS

Myeloid-derived suppressor cells: Natural regulators for transplant tolerance

(2010) Peter Boros et al.   HUMAN IMMUNOLOGY

Ectosomes Released by Polymorphonuclear Neutrophils Induce a MerTK-dependent Anti-inflammatory Pathway in Macrophages

(2010) Ceylan Eken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice

(2010) Mercedes Rodriguez Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice

(2010) Filip K. Swirski et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Production of Vascular Endothelial Growth Factors from Human Lung Macrophages Induced by Group IIA and Group X Secreted Phospholipases A2

(2010) F. Granata et al.   JOURNAL OF IMMUNOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic Cells Activate the "Phoenix Rising" Pathway to Promote Wound Healing and Tissue Regeneration

(2010) F. Li et al.   Science Signaling

An anatomical view on macrophages in tolerance

(2009) Fredrik Wermeling et al.   AUTOIMMUNITY REVIEWS

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

Molecular Imaging of Innate Immune Cell Function in Transplant Rejection

(2009) Thomas Christen et al.   CIRCULATION

Absence of Thrombospondin-2 Causes Age-Related Dilated Cardiomyopathy

(2009) Melissa Swinnen et al.   CIRCULATION

Differential Macrophage Polarization in Male and Female BALB/c Mice Infected With Coxsackievirus B3 Defines Susceptibility to Viral Myocarditis

(2009) Kang Li et al.   CIRCULATION RESEARCH

Critical Role for Leukocyte Hypoxia Inducible Factor-1α Expression in Post-Myocardial Infarction Left Ventricular Remodeling

(2009) Feng Dong et al.   CIRCULATION RESEARCH

Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation

(2009) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

MHC Class I/Peptide Transfer between Dendritic Cells Overcomes Poor Cross-Presentation by Monocyte-Derived APCs That Engulf Dying Cells

(2009) C. Qu et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis of Apoptotic Cells by Neutrophil Granulocytes: Diminished Proinflammatory Neutrophil Functions in the Presence of Apoptotic Cells

(2009) Lars Esmann et al.   JOURNAL OF IMMUNOLOGY

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Leukocyte and Neutrophil Counts With Infarct Size, Left Ventricular Function and Outcomes After Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction

(2008) Stanley Chia et al.   AMERICAN JOURNAL OF CARDIOLOGY

Monocyte Infiltration and Kidney Allograft Dysfunction During Acute Rejection

(2008) R. Girlanda et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Cardioprotective Function of the Long Pentraxin PTX3 in Acute Myocardial Infarction

(2008) Monica Salio et al.   CIRCULATION

Chagas Heart Disease Pathogenesis: One Mechanism or Many?

(2008) Kevin Bonney et al.   CURRENT MOLECULAR MEDICINE

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

(2008) Richard K. Tsai et al.   JOURNAL OF CELL BIOLOGY

Glucose Regulation of Integrin-Associated Protein Cleavage Controls the Response of Vascular Smooth Muscle Cells to Insulin-Like Growth Factor-I

(2008) Laura A. Maile et al.   MOLECULAR ENDOCRINOLOGY

PAI-1 inhibits neutrophil efferocytosis

(2008) Y.-J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms

(2008) X. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Uptake of Apoptotic Cells Drives Coxiella burnetii Replication and Macrophage Polarization: A Model for Q Fever Endocarditis

(2008) Marie Benoit et al.   PLoS Pathogens