HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis

Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide

(2015) Wonki Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway

(2015) Csörsz Nagy et al.   Frontiers in Immunology

Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis

(2014) Elke Marsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phagocyte–myocyte interactions and consequences during hypoxic wound healing

(2014) Shuang Zhang et al.   CELLULAR IMMUNOLOGY

Macrophage HIF-2  Ameliorates Adipose Tissue Inflammation and Insulin Resistance in Obesity

(2014) S. S. Choe et al.   DIABETES

Tim4- and MerTK-Mediated Engulfment of Apoptotic Cells by Mouse Resident Peritoneal Macrophages

(2014) C. Nishi et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia-Inducible Factor/MAZ-Dependent Induction of Caveolin-1 Regulates Colon Permeability through Suppression of Occludin, Leading to Hypoxia-Induced Inflammation

(2014) Liwei Xie et al.   MOLECULAR AND CELLULAR BIOLOGY

Normoxic regulation of HIF-1α in prostate cancer

(2014) Weranja K. B. Ranasinghe et al.   Nature Reviews Urology

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Hypoxia enhances lipid uptake in macrophages: Role of the scavenger receptors Lox1, SRA, and CD36

(2013) Margot Crucet et al.   ATHEROSCLEROSIS

Hypoxia-inducible factor 2  regulates key neutrophil functions in humans, mice, and zebrafish

(2013) A. A. R. Thompson et al.   BLOOD

Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction

(2013) Elaine Wan et al.   CIRCULATION RESEARCH

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2  (HIF2 ) Cooperatively Activate HIF2 Target Genes during Hypoxia

(2012) M. R. Pawlus et al.   MOLECULAR AND CELLULAR BIOLOGY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

Induction of CD36 and Thrombospondin-1 in Macrophages by Hypoxia-Inducible Factor 1 and Its Relevance in the Inflammatory Process

(2012) Dolores Ortiz-Masià et al.   PLoS One

Functional regulation of HIF-1α under normoxia-is there more than post-translational regulation?

(2011) A. Kuschel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element

(2011) J Xu et al.   ONCOGENE

Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model

(2011) C. J. Harvey et al.   Science Translational Medicine

Opposing roles for HIF-1  and HIF-2  in the regulation of angiogenesis by mononuclear phagocytes

(2010) T. D. Eubank et al.   BLOOD

Knockout of HIF-1  in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses

(2010) C. Werno et al.   CARCINOGENESIS

Differential activation and antagonistic function of HIF-  isoforms in macrophages are essential for NO homeostasis

(2010) N. Takeda et al.   GENES & DEVELOPMENT

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

(2010) Hongxia Z. Imtiyaz et al.   JOURNAL OF CLINICAL INVESTIGATION

The supernatant of apoptotic cells causes transcriptional activation of hypoxia-inducible factor-1  in macrophages via sphingosine-1-phosphate and transforming growth factor- 

(2009) B. Herr et al.   BLOOD

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

(2009) H.-Y. Fang et al.   BLOOD

Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion

(2009) A. Varin et al.   BLOOD

Hypoxia Up-regulates CD36 Expression and Function via Hypoxia-inducible Factor-1- and Phosphatidylinositol 3-Kinase-dependent Mechanisms

(2009) Bupe R. Mwaikambo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Oxygen Sensing Modulates Antigen Presentation and Phagocytic Functions Involving IFN-  Production through the HIF-1  Transcription Factor

(2009) B. Acosta-Iborra et al.   JOURNAL OF IMMUNOLOGY

Transglutaminase 2 Is Needed for the Formation of an Efficient Phagocyte Portal in Macrophages Engulfing Apoptotic Cells

(2009) B. Toth et al.   JOURNAL OF IMMUNOLOGY

Differential regulation of HIF-1α isoforms in murine macrophages by TLR4 and adenosine A2A receptor agonists

(2009) Madhuri Ramanathan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sec22b Is a Negative Regulator of Phagocytosis in Macrophages

(2009) Kiyotaka Hatsuzawa et al.   MOLECULAR BIOLOGY OF THE CELL

Hypoxia-inducible factor-1α suppresses the expression of macrophage scavenger receptor 1

(2009) Ken Shirato et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

Transglutaminase 2 protects against ischemic insult, interacts with HIF1β, and attenuates HIF1 signaling

(2008) Anthony J. Filiano et al.   FASEB JOURNAL

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

(2008) Yatrik M. Shah et al.   GASTROENTEROLOGY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE