Activation and Role of NACHT, LRR, and PYD Domains-Containing Protein 3 Inflammasome in RNA Viral Infection

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation

(2017) Ernest T. Chivero et al.   JOURNAL OF NEUROSCIENCE

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

(2017) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex

(2017) Wenbiao Wang et al.   PLoS Pathogens

HIV Promotes NLRP3 Inflammasome Complex Activation in Murine HIV-Associated Nephropathy

(2016) Shabirul Haque et al.   AMERICAN JOURNAL OF PATHOLOGY

Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys

(2016) Dan H. Barouch et al.   CELL

Inflammasomes and its importance in viral infections

(2016) Gaurav Shrivastava et al.   IMMUNOLOGIC RESEARCH

PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome

(2016) Anita Pinar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation

(2016) Manmeet K. Mamik et al.   Journal of Neuroimmune Pharmacology

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion

(2016) Miyu Moriyama et al.   JOURNAL OF VIROLOGY

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18–dependent activation

(2016) Liyen Loh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

(2016) P. S. Pillai et al.   SCIENCE

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

(2016) Jinyan Liu et al.   SCIENCE

Viruses and the Diversity of Cell Death

(2016) Pranav Danthi   Annual Review of Virology

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

(2016) Michelle D. Tate et al.   Scientific Reports

Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells

(2016) H. M. Kofahi et al.   Scientific Reports

RNase L Activates the NLRP3 Inflammasome during Viral Infections

(2015) Arindam Chakrabarti et al.   Cell Host & Microbe

The Endoribonuclease Activity Essential for the Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus to Inhibit NLRP3 Inflammasome-Mediated IL-1β Induction

(2015) Chao Wang et al.   DNA AND CELL BIOLOGY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism

(2015) Steven McRae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DDX19A Senses Viral RNA and Mediates NLRP3-Dependent Inflammasome Activation

(2015) Jiangnan Li et al.   JOURNAL OF IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

(2015) Jose L. Nieto-Torres et al.   VIROLOGY

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3

(2015) Seokwon Kang et al.   Nature Communications

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

(2015) Hongbin Wang et al.   Cell Reports

Inflammasome control of viral infection

(2015) Christopher Lupfer et al.   Current Opinion in Virology

Involvement of NLRP3 inflammasome in CVB3-induced viral myocarditis

(2014) Yan Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

IL-1R1 Signaling Regulates CXCL12-Mediated T Cell Localization and Fate within the Central Nervous System during West Nile Virus Encephalitis

(2014) Douglas M. Durrant et al.   JOURNAL OF IMMUNOLOGY

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

(2014) Xiaqiong Wang et al.   NATURE IMMUNOLOGY

The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3

(2014) Manira Rayamajhi et al.   NATURE IMMUNOLOGY

HCV Genomic RNA Activates the NLRP3 Inflammasome in Human Myeloid Cells

(2014) Wei Chen et al.   PLoS One

Rhinovirus-Induced Calcium Flux Triggers NLRP3 and NLRC5 Activation in Bronchial Cells

(2013) Kathy Triantafilou et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation

(2013) E. D. Hottz et al.   BLOOD

The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome

(2013) Hiroki Mitoma et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Dengue virus-infected human monocytes trigger late activation of caspase-1, which mediates pro-inflammatory IL-1  secretion and pyroptosis

(2013) T. Y. Tan et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus

(2013) Iris K Pang et al.   NATURE IMMUNOLOGY

IRAK-1 bypasses priming and directly links TLRs to rapid NLRP3 inflammasome activation

(2013) K.-M. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells

(2013) Julien Pothlichet et al.   PLoS Pathogens

Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

(2013) Julie L. McAuley et al.   PLoS Pathogens

IL-1β Production through the NLRP3 Inflammasome by Hepatic Macrophages Links Hepatitis C Virus Infection with Liver Inflammation and Disease

(2013) Amina A. Negash et al.   PLoS Pathogens

Pyrin- and CARD-only Proteins as Regulators of NLR Functions

(2013) Hongnga T. Le et al.   Frontiers in Immunology

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Viroporins: structure and biological functions

(2012) José Luis Nieva et al.   NATURE REVIEWS MICROBIOLOGY

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis

(2012) Deepak Kumar Kaushik et al.   PLoS One

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

(2012) Kathy Triantafilou et al.   THORAX

Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome

(2012) Minako Ito et al.   PLoS Pathogens

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

(2012) Hilario J. Ramos et al.   PLoS Pathogens

Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1  Secretion

(2011) N. Komune et al.   JOURNAL OF VIROLOGY

The NLRP3 Inflammasome Detects Encephalomyocarditis Virus and Vesicular Stomatitis Virus Infection

(2011) J. V. Rajan et al.   JOURNAL OF VIROLOGY

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Interleukin 18 Coexpression during Respiratory Syncytial Virus Infection Results in Enhanced Disease Mediated by Natural Killer Cells

(2010) J. A. Harker et al.   JOURNAL OF VIROLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Interleukin-1 (IL-1) Pathway

(2010) A. Weber et al.   Science Signaling

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Japanese encephalitis virus differentially modulates the induction of multiple pro-inflammatory mediators in human astrocytoma and astroglioma cell-lines

(2008) M MISHRA et al.   CELL BIOLOGY INTERNATIONAL

The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis

(2008) Natalie A. Prow et al.   JOURNAL OF NEUROCHEMISTRY