Activation of the NLRP3 Inflammasome by IAV Virulence Protein PB1-F2 Contributes to Severe Pathophysiology and Disease

Strain-dependent effects of PB1-F2 of triple-reassortant H3N2 influenza viruses in swine

(2012) L. Pena et al.   JOURNAL OF GENERAL VIROLOGY

Restored PB1-F2 in the 2009 Pandemic H1N1 Influenza Virus Has Minimal Effects in Swine

(2012) L. Pena et al.   JOURNAL OF VIROLOGY

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The influenza virus PB1-F2 protein has interferon antagonistic activity

(2011) Sabine E. Dudek et al.   BIOLOGICAL CHEMISTRY

Mitochondria: commanders of innate immunity and disease?

(2011) Suzanne M Cloonan et al.   CURRENT OPINION IN IMMUNOLOGY

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Behaviour of influenza A viruses differentially expressing segment 2 gene products in vitro and in vivo

(2011) S. Tauber et al.   JOURNAL OF GENERAL VIROLOGY

Immunopathogenic and Antibacterial Effects of H3N2 Influenza A Virus PB1-F2 Map to Amino Acid Residues 62, 75, 79, and 82

(2011) I. V. Alymova et al.   JOURNAL OF VIROLOGY

Microbiota regulates immune defense against respiratory tract influenza A virus infection

(2011) T. Ichinohe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

(2011) Seth L. Masters et al.   TRENDS IN MOLECULAR MEDICINE

The influenza A virus protein PB1-F2

(2011) Zsuzsanna T. Varga et al.   Virulence

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

The Inflammasomes

(2010) Kate Schroder et al.   CELL

PB1-F2 Influenza A Virus Protein Adopts a β-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments

(2010) Christophe Chevalier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The biological paths of IL-1 family members IL-18 and IL-33

(2010) Dirk E. Smith   JOURNAL OF LEUKOCYTE BIOLOGY

A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo

(2010) G. M. Conenello et al.   JOURNAL OF VIROLOGY

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Viral Disorder or Disordered Viruses: Do Viral Proteins Possess Unique Features?

(2010) Bin Xue et al.   PROTEIN AND PEPTIDE LETTERS

Inflammasomes as mediators of immunity against influenza virus

(2010) Iris K. Pang et al.   TRENDS IN IMMUNOLOGY

PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology

(2010) Julie L. McAuley et al.   PLoS Pathogens

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Fluorescent Indicators for Intracellular pH

(2009) Junyan Han et al.   CHEMICAL REVIEWS

Fighting the Flu with Inflammasome Signaling

(2009) David M. Owen et al.   IMMUNITY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA

(2009) H. M. Wise et al.   JOURNAL OF VIROLOGY

The Effects of Influenza A Virus PB1-F2 Protein on Polymerase Activity Are Strain Specific and Do Not Impact Pathogenesis

(2009) J. L. McAuley et al.   JOURNAL OF VIROLOGY

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens