Viroporins: structure and biological functions

High-Risk Human Papillomavirus E5 Oncoprotein Displays Channel-Forming Activity Sensitive to Small-Molecule Inhibitors

(2012) L. F. Wetherill et al.   JOURNAL OF VIROLOGY

Classical Swine Fever Virus p7 Protein Is a Viroporin Involved in Virulence in Swine

(2012) D. P. Gladue et al.   JOURNAL OF VIROLOGY

A Cytoplasmic Tail Determinant in HIV-1 Vpu Mediates Targeting of Tetherin for Endosomal Degradation and Counteracts Interferon-Induced Restriction

(2012) Tonya Kueck et al.   PLoS Pathogens

Background K2P Channels KCNK3/9/15 Limit the Budding of Cell Membrane-derived Vesicles

(2011) Daniel Tsung-Ning Huang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

DIDS blocks a chloride-dependent current that is mediated by the 2B protein of enterovirus 71

(2011) Shiqi Xie et al.   CELL RESEARCH

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus

(2011) Jun Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel

(2011) Toshana L. Foster et al.   HEPATOLOGY

Membrane Integration of Poliovirus 2B Viroporin

(2011) L. Martinez-Gil et al.   JOURNAL OF VIROLOGY

Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu

(2011) J. G. Magadan et al.   JOURNAL OF VIROLOGY

Human Annexin A6 Interacts with Influenza A Virus Protein M2 and Negatively Modulates Infection

(2011) H. Ma et al.   JOURNAL OF VIROLOGY

Host factors involved in retroviral budding and release

(2011) Juan Martin-Serrano et al.   NATURE REVIEWS MICROBIOLOGY

Modulation of HIV-1-host interaction: role of the Vpu accessory protein

(2011) Mathieu Dubé et al.   Retrovirology

HIV-1 Vpu Antagonizes BST-2 by Interfering Mainly with the Trafficking of Newly Synthesized BST-2 to the Cell Surface

(2011) Mathieu Dubé et al.   TRAFFIC

The SV40 Late Protein VP4 Is a Viroporin that Forms Pores to Disrupt Membranes for Viral Release

(2011) Smita Raghava et al.   PLoS Pathogens

A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-α-2b and nucleoside analogues

(2010) Carolyn A. Luscombe et al.   ANTIVIRAL RESEARCH

Viral channel forming proteins — Modeling the target

(2010) Wolfgang B. Fischer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influenza M2 proton channels

(2010) Rafal M. Pielak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Secondary structure, dynamics, and architecture of the p7 membrane protein from hepatitis C virus by NMR spectroscopy

(2010) Gabriel A. Cook et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Viral proteins function as ion channels

(2010) Kai Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane Potential Depolarization as a Triggering Mechanism for Vpu-Mediated HIV-1 Release

(2010) Kate Hsu et al.   BIOPHYSICAL JOURNAL

Viral Reorganization of the Secretory Pathway Generates Distinct Organelles for RNA Replication

(2010) Nai-Yun Hsu et al.   CELL

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Cell permeabilization by poliovirus 2B viroporin triggers bystander permeabilization in neighbouring cells through a mechanism involving gap junctions

(2010) Vanesa Madan et al.   CELLULAR MICROBIOLOGY

The Vpu Protein: New Concepts in Virus Release and CD4 Down-Modulation

(2010) Autumn Ruiz et al.   CURRENT HIV RESEARCH

Effects of human T-cell leukemia virus type 1 (HTLV-1) p13 on mitochondrial K+ permeability: A new member of the viroporin family?

(2010) Micol Silic-Benussi et al.   FEBS LETTERS

NMR Structure and Ion Channel Activity of the p7 Protein from Hepatitis C Virus

(2010) Roland Montserret et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

(2010) Sarah D. Cady et al.   NATURE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

(2010) R. Acharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proton and cation transport activity of the M2 proton channel from influenza A virus

(2010) T. Leiding et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomerization state and supramolecular structure of the HIV-1 Vpu protein transmembrane segment in phospholipid bilayers

(2010) Jun-Xia Lu et al.   PROTEIN SCIENCE

Insight into the Mechanism of the Influenza A Proton Channel from a Structure in a Lipid Bilayer

(2010) M. Sharma et al.   SCIENCE

BST-2/tetherin: a new component of the innate immune response to enveloped viruses

(2010) David T. Evans et al.   TRENDS IN MICROBIOLOGY

Combination Chemotherapy for Influenza

(2010) Elena A. Govorkova et al.   Viruses-Basel

Hepatitis C Virus P7—A Viroporin Crucial for Virus Assembly and an Emerging Target for Antiviral Therapy

(2010) Eike Steinmann et al.   Viruses-Basel

Rotavirus Disrupts Calcium Homeostasis by NSP4 Viroporin Activity

(2010) J. M. Hyser et al.   mBio

The Human Polyoma JC Virus Agnoprotein Acts as a Viroporin

(2010) Tadaki Suzuki et al.   PLoS Pathogens

Antiviral Efficacy of the Novel Compound BIT225 against HIV-1 Release from Human Macrophages

(2009) G. Khoury et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells

(2009) David Perez-Caballero et al.   CELL

Viral calciomics: Interplays between Ca2+ and virus

(2009) Yubin Zhou et al.   CELL CALCIUM

Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

(2009) Monique Gannagé et al.   Cell Host & Microbe

No beneficial effects of amantadine in treatment of chronic hepatitis C patients

(2009) Hanneke van Soest et al.   DIGESTIVE AND LIVER DISEASE

HIV-1 Accessory Protein Vpu Internalizes Cell-surface BST-2/Tetherin through Transmembrane Interactions Leading to Lysosomes

(2009) Yukie Iwabu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Determinants Important for Hepatitis C Virus p7 Function in Morphogenesis by Using trans-Complementation

(2009) C. Brohm et al.   JOURNAL OF VIROLOGY

Influenza A Virus Lacking M2 Protein as a Live Attenuated Vaccine

(2009) S. Watanabe et al.   JOURNAL OF VIROLOGY

Model generation of viral channel forming 2B protein bundles from polio and coxsackie viruses

(2009) George Patargias et al.   MOLECULAR MEMBRANE BIOLOGY

Emerging roles for lipids in shaping membrane-protein function

(2009) Rob Phillips et al.   NATURE

Plugging the holes in hepatitis C virus antiviral therapy

(2009) S. D. C. Griffin   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy

(2009) P. Luik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and Structural Characterization of 2B Viroporin Membranolytic Domains†

(2008) Silvia Sánchez-Martínez et al.   BIOCHEMISTRY

The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

(2008) Nanette Van Damme et al.   Cell Host & Microbe

Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel

(2008) Stephen Griffin et al.   HEPATOLOGY

Functional Analysis of Picornavirus 2B Proteins: Effects on Calcium Homeostasis and Intracellular Protein Trafficking

(2008) A. S. de Jong et al.   JOURNAL OF VIROLOGY

Expression of Nonstructural Rotavirus Protein NSP4 Mimics Ca2+ Homeostasis Changes Induced by Rotavirus Infection in Cultured Cells

(2008) Y. Diaz et al.   JOURNAL OF VIROLOGY

Structure and mechanism of the M2 proton channel of influenza A virus

(2008) Jason R. Schnell et al.   NATURE

Structural basis for the function and inhibition of an influenza virus proton channel

(2008) Amanda L. Stouffer et al.   NATURE

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Proton Transport through Influenza A Virus M2 Protein Reconstituted in Vesicles

(2007) J. Craig Moffat et al.   BIOPHYSICAL JOURNAL