Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

(2016) Su-Jin Heo et al.   BIOPHYSICAL JOURNAL

Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension

(2016) Paul T. Arsenovic et al.   BIOPHYSICAL JOURNAL

The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

(2016) Balázs Enyedi et al.   CELL

The nucleus is a conserved mechanosensation and mechanoresponse organelle

(2016) Alexandra P. Navarro et al.   Cytoskeleton

Nuclear envelope rupture is induced by actin-based nucleus confinement

(2016) Emily M. Hatch et al.   JOURNAL OF CELL BIOLOGY

Impaired mechanical response of an EDMD mutation leads to motility phenotypes that are repaired by loss of prenylation

(2016) Noam Zuela et al.   JOURNAL OF CELL SCIENCE

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis

(2016) Michael I. Robson et al.   MOLECULAR CELL

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage

(2016) Gunes Uzer et al.   STEM CELLS

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation

(2016) Yin-Quan Chen et al.   Scientific Reports

Universally Conserved Relationships between Nuclear Shape and Cytoplasmic Mechanical Properties in Human Stem Cells

(2016) Oswaldo A. Lozoya et al.   Scientific Reports

Under Pressure: Mechanical Stress Management in the Nucleus

(2016) Néjma Belaadi et al.   Cells

Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner

(2016) Kristina Haase et al.   Scientific Reports

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

Cytoskeletal tension induces the polarized architecture of the nucleus

(2015) Dong-Hwee Kim et al.   BIOMATERIALS

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

(2015) Tristan P. Driscoll et al.   BIOPHYSICAL JOURNAL

Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos

(2015) Adriana Gonzalez-Sandoval et al.   CELL

Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion

(2015) Inmaculada Navarro-Lérida et al.   DEVELOPMENTAL CELL

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear–cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions

(2015) Rachel M. Stewart et al.   JOURNAL OF CELL BIOLOGY

E-cadherin junctions as active mechanical integrators in tissue dynamics

(2015) Thomas Lecuit et al.   NATURE CELL BIOLOGY

Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension

(2015) Teemu O. Ihalainen et al.   NATURE MATERIALS

Nuclear deformability and telomere dynamics are regulated by cell geometric constraints

(2015) Ekta Makhija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Mechanosensitivity to Extremely Low-Magnitude Signals Is Enabled by a LINCed Nucleus

(2015) Gunes Uzer et al.   STEM CELLS

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

(2015) Sarah M. Schreiner et al.   Nature Communications

Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer

(2015) Ayaka Matsumoto et al.   Cancer Medicine

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

(2015) Su-Jin Heo et al.   Scientific Reports

The regulation of gene expression during onset of differentiation by nuclear mechanical heterogeneity

(2014) Shefali Talwar et al.   BIOMATERIALS

Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells

(2014) Alexandre J. S. Ribeiro et al.   Cellular and Molecular Bioengineering

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

The SUN protein Mps3 controls Ndc1 distribution and function on the nuclear membrane

(2014) Jingjing Chen et al.   JOURNAL OF CELL BIOLOGY

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue

(2014) J. Swift et al.   JOURNAL OF CELL SCIENCE

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Auxetic nuclei in embryonic stem cells exiting pluripotency

(2014) Stefano Pagliara et al.   NATURE MATERIALS

Cellular mechanosensing: Getting to the nucleus of it all

(2014) Gregory R. Fedorchak et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

LINC complexes in health and disease

(2014) Alexandre Méjat   Nucleus

Transient Receptor Potential Channels and Mechanosensation

(2013) Niels Eijkelkamp et al.   Annual Review of Neuroscience

Direct Measurement of Intranuclear Strain Distributions and RNA Synthesis in Single Cells Embedded within Native Tissue

(2013) Jonathan T. Henderson et al.   BIOPHYSICAL JOURNAL

Correlated Spatio-Temporal Fluctuations in Chromatin Compaction States Characterize Stem Cells

(2013) Shefali Talwar et al.   BIOPHYSICAL JOURNAL

Osmotic Challenge Drives Rapid and Reversible Chromatin Condensation in Chondrocytes

(2013) Jerome Irianto et al.   BIOPHYSICAL JOURNAL

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Crosstalk between Caveolin-1/Extracellular Signal-regulated Kinase (ERK) and β-Catenin Survival Pathways in Osteocyte Mechanotransduction

(2013) Arancha R. Gortazar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

(2013) Katarina Wolf et al.   JOURNAL OF CELL BIOLOGY

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Lamin A/C is Expressed in Pluripotent Mouse Embryonic Stem Cells

(2013) Melanie A. Eckersley-Maslin et al.   Nucleus

Mechanical Activation of Cells Induces Chromatin Remodeling Preceding MKL Nuclear Transport

(2012) K. Venkatesan Iyer et al.   BIOPHYSICAL JOURNAL

Chromatin Decondensation and Nuclear Softening Accompany Nanog Downregulation in Embryonic Stem Cells

(2012) Kevin J. Chalut et al.   BIOPHYSICAL JOURNAL

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina

(2012) Joseph M. Zullo et al.   CELL

Quantifying cellular differentiation by physical phenotype using digital holographic microscopy

(2012) Kevin J. Chalut et al.   Integrative Biology

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The complex world of WNT receptor signalling

(2012) Christof Niehrs   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells

(2012) Yeh-Chuin Poh et al.   Nature Communications

Biophysical Regulation of Histone Acetylation in Mesenchymal Stem Cells

(2011) Yuan Li et al.   BIOPHYSICAL JOURNAL

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei

(2010) Heidi N. Fridolfsson et al.   JOURNAL OF CELL BIOLOGY

Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

(2010) E. S. Folker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Lamin-binding Proteins

(2010) K. L. Wilson et al.   Cold Spring Harbor Perspectives in Biology

Spatio-Temporal Plasticity in Chromatin Organization in Mouse Cell Differentiation and during Drosophila Embryogenesis

(2009) Dipanjan Bhattacharya et al.   BIOPHYSICAL JOURNAL

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

A ZYG-12–dynein interaction at the nuclear envelope defines cytoskeletal architecture in theC. elegansgonad

(2009) Kang Zhou et al.   JOURNAL OF CELL BIOLOGY

A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to Microtubules

(2008) Megan C. King et al.   CELL

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

Nuclear mechanotransduction: Response of the lamina to extracellular stress with implications in aging

(2008) Julia T. Philip et al.   JOURNAL OF BIOMECHANICS

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY