Metal Dyshomeostasis and Their Pathological Role in Prion and Prion-Like Diseases: The Basis for a Nutritional Approach

Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases

(2018) Silvia A. Mandel et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

(2018) William L. Klein   JOURNAL OF ALZHEIMERS DISEASE

Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis

(2018) Balwinder Singh et al.   JOURNAL OF ALZHEIMERS DISEASE

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice

(2016) Chuang Guo et al.   EXPERIMENTAL NEUROLOGY

Metal chelation, radical scavenging and inhibition of Aβ42 fibrillation by food constituents in relation to Alzheimer’s disease

(2016) Stephen Chan et al.   FOOD CHEMISTRY

Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein

(2016) Esaú E. Rodríguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Synuclein expression in the lizard Anolis carolinensis

(2016) Mattia Toni et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY

Parkinson Disease and Dementia

(2016) Sara Garcia-Ptacek et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Coordination and redox properties of copper interaction with α-synuclein

(2016) Daniela Valensin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers

(2016) Cathryn L. Ugalde et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo MRI Mapping of Brain Iron Deposition across the Adult Lifespan

(2016) J. Acosta-Cabronero et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β and α-Synuclein Decrease the Level of Metal-Catalyzed Reactive Oxygen Species by Radical Scavenging and Redox Silencing

(2016) Jeppe T. Pedersen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

(2016) Li-Na Lu et al.   MOLECULAR NEUROBIOLOGY

Determinants of iron accumulation in the normal aging brain

(2016) Lukas Pirpamer et al.   NEUROBIOLOGY OF AGING

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease

(2016) Lary C. Walker et al.   Cold Spring Harbor Perspectives in Medicine

Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson’s Disease

(2016) Giorgio Vivacqua et al.   PLoS One

Mediterranean diet and preserved brain structural connectivity in older subjects

(2015) Amandine Pelletier et al.   Alzheimers & Dementia

Prion Protein and Copper Cooperatively Protect Neurons by Modulating NMDA Receptor Through S-nitrosylation

(2015) Lisa Gasperini et al.   ANTIOXIDANTS & REDOX SIGNALING

Beta-Amyloid and Tau-Protein: Structure, Interaction, and Prion-Like Properties

(2015) O. G. Tatarnikova et al.   BIOCHEMISTRY-MOSCOW

Fish Synucleins: An Update

(2015) Mattia Toni et al.   Marine Drugs

Reactivity of copper–α-synuclein peptide complexes relevant to Parkinson's disease

(2015) Simone Dell'Acqua et al.   Metallomics

Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc

(2015) Rachel Pass et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Alpha-synuclein oligomers and fibrils originate in two distinct conformer pools: a small angle X-ray scattering and ensemble optimisation modelling study

(2015) Cyril C. Curtain et al.   Molecular BioSystems

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

(2015) Richard Ortega et al.   MOLECULAR NEUROBIOLOGY

Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases

(2015) Carlos Fernández-Moriano et al.   Oxidative Medicine and Cellular Longevity

The prion-ZIP connection: From cousins to partners in iron uptake

(2015) Neena Singh et al.   Prion

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion

(2015) Gabriele Giachin et al.   Scientific Reports

Mediterranean Diet and Age-Related Cognitive Decline

(2015) Cinta Valls-Pedret et al.   JAMA Internal Medicine

Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives

(2015) Kyle J. Korshavn et al.   Scientific Reports

Health Benefits of the Mediterranean Diet

(2014) Efthymios Gotsis et al.   ANGIOLOGY

A Revised Picture of the Cu(II)−α-Synuclein Complex: The Role of N-Terminal Acetylation

(2014) Gina M. Moriarty et al.   BIOCHEMISTRY

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Structural Determinants in Prion Protein Folding and Stability

(2014) Federico Benetti et al.   JOURNAL OF MOLECULAR BIOLOGY

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

(2014) A. V. Witte et al.   JOURNAL OF NEUROSCIENCE

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Aggregate-Depleted Brain Fails to Induce Aβ Deposition in a Mouse Model of Alzheimer's Disease

(2014) Claudia Duran-Aniotz et al.   PLoS One

In vitro aggregation assays for the characterization of α-synuclein prion-like properties

(2014) Joanna Narkiewicz et al.   Prion

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein spreading in Parkinson’s disease

(2014) Ariadna Recasens et al.   Frontiers in Neuroanatomy

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Commentary

(2013) Cinta Valls-Pedret et al.   EPIDEMIOLOGY

Oxidative damage to macromolecules in human Parkinson disease and the rotenone model

(2013) Laurie H. Sanders et al.   FREE RADICAL BIOLOGY AND MEDICINE

Copper(I)-α-Synuclein Interaction: Structural Description of Two Independent and Competing Metal Binding Sites

(2013) Francesca Camponeschi et al.   INORGANIC CHEMISTRY

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

(2013) Stefan Schildknecht et al.   JOURNAL OF NEUROCHEMISTRY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Copper pathology in vulnerable brain regions in Parkinson's disease

(2013) Katherine M. Davies et al.   NEUROBIOLOGY OF AGING

Employing Alzheimer Disease Animal Models for Translational Research: Focus on Dietary Components

(2013) Cristina Grossi et al.   Neurodegenerative Diseases

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

The Polyphenol Oleuropein Aglycone Protects TgCRND8 Mice against Aß Plaque Pathology

(2013) Cristina Grossi et al.   PLoS One

Neuronal zinc regulation and the prion protein

(2013) Nicole T. Watt et al.   Prion

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Mediterranean Diet and White Matter Hyperintensity Volume in the Northern Manhattan Study

(2012) Hannah Gardener   ARCHIVES OF NEUROLOGY

Effects of the Pathological Q212P Mutation on Human Prion Protein Non-Octarepeat Copper-Binding Site

(2012) Paola D’Angelo et al.   BIOCHEMISTRY

Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

(2012) Gözde Eskici et al.   BIOCHEMISTRY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Transmissible Proteins: Expanding the Prion Heresy

(2012) Claudio Soto   CELL

Bioinorganic chemistry of copper coordination to alpha-synuclein: Relevance to Parkinson's disease

(2012) Andrés Binolfi et al.   COORDINATION CHEMISTRY REVIEWS

Updated Knowledge about Polyphenols: Functions, Bioavailability, Metabolism, and Health

(2012) J. M. Landete   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Protective Effects of Merlot Red Wine Extract and its Major Polyphenols in Pc12 Cells under Oxidative Stress Conditions

(2012) Sara Martín et al.   JOURNAL OF FOOD SCIENCE

The association between Mediterranean diet adherence and Parkinson's disease

(2012) Roy N. Alcalay et al.   MOVEMENT DISORDERS

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

(2012) O. M. Siggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Curcumin protects nigral dopaminergic neurons by iron-chelation in the 6-hydroxydopamine rat model of Parkinson’s disease

(2012) Xi-Xun Du et al.   Neuroscience Bulletin

Phosphorylation of α-Synuclein at Y125 and S129 Alters Its Metal Binding Properties: Implications for Understanding the Role of α-Synuclein in the Pathogenesis of Parkinson’s Disease and Related Disorders

(2011) Yu Lu et al.   ACS Chemical Neuroscience

Importance of Iron Chelation in Free Radical-Induced Oxidative Stress and Human Disease

(2011) Klaudia Jomova et al.   CURRENT PHARMACEUTICAL DESIGN

Neuroprotective properties of Spanish red wine and its isolated polyphenols on astrocytes

(2011) Sara Martín et al.   FOOD CHEMISTRY

Redox activity of α-synuclein–Cu is silenced by Zn7-metallothionein-3

(2011) Gabriele Meloni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate

(2011) Raku Shinkyo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity

(2011) Pablo Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T α-Synuclein

(2011) Katherine C. M. Chew et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

The Alzheimer’s therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

(2011) Peter J. Crouch et al.   JOURNAL OF NEUROCHEMISTRY

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

(2011) Rebecca F. Rosen et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Copper is toxic to PrP-ablated mice and exacerbates disease in a mouse model of E200K genetic prion disease

(2011) Tamar Canello et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Resveratrol Acts Not through Anti-Aggregative Pathways but Mainly via Its Scavenging Properties against Aβ and Aβ-Metal Complexes Toxicity

(2011) Alberto Granzotto et al.   PLoS One

The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

(2011) Jason R. Cannon et al.   TOXICOLOGICAL SCIENCES

Mechanism of copper(II)-induced misfolding of Parkinson's disease protein

(2011) Frisco Rose et al.   Scientific Reports

Redox Reactions of the α-Synuclein−Cu2+Complex and Their Effects on Neuronal Cell Viability

(2010) Chengshan Wang et al.   BIOCHEMISTRY

Resveratrol attenuates 6-hydroxydopamine-induced oxidative damage and dopamine depletion in rat model of Parkinson's disease

(2010) Mohd.Moshahid Khan et al.   BRAIN RESEARCH

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different sub-cellular localization of alpha-synuclein in the C57BL\6J mouse's central nervous system by two novel monoclonal antibodies

(2010) G. Vivacqua et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Iron chelation and neuroprotection in neurodegenerative diseases

(2010) Xuping Li et al.   JOURNAL OF NEURAL TRANSMISSION

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

(2010) Marcus W. Brazier et al.   JOURNAL OF NEUROCHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Evidence for Copper-dioxygen Reactivity during α-Synuclein Fibril Formation

(2010) Heather R. Lucas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prions and manganese: A maddening beast

(2010) David R. Brown   Metallomics

Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease

(2010) Jia-Yi Li et al.   MOVEMENT DISORDERS

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Iron overload triggers redox-sensitive signals in human IMR-32 neuroblastoma cells

(2010) Gabriela A. Salvador et al.   NEUROTOXICOLOGY

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Chemistry and Biochemistry of Dietary Polyphenols

(2010) Rong Tsao   Nutrients

Food synergy: an operational concept for understanding nutrition

(2009) David R Jacobs et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Copper Coordination by Familial Mutants of Parkinson’s Disease-Associated α-Synuclein

(2009) Simon C. Drew et al.   APPLIED MAGNETIC RESONANCE

Mediterranean Diet and Mild Cognitive Impairment

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Role of copper and manganese in prion disease progression

(2009) Gerda Mitteregger et al.   BRAIN RESEARCH

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

(2009) Nathan R. Perron et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Manganese-Induced Dopaminergic Neurodegeneration: Insights into Mechanisms and Genetics Shared with Parkinson’s Disease

(2009) Alexandre Benedetto et al.   CHEMICAL REVIEWS

Prion metal interaction: Is prion pathogenesis a cause or a consequence of metal imbalance?

(2009) Anshul Rana et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia

(2009) Catherine Féart   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322

(2009) Zhong-Ying Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of α-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes

(2009) Yong Peng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Relationship between Blood Levels of Heavy Metals and Parkinson’s Disease in China

(2009) Tetsuhito Fukushima et al.   NEUROEPIDEMIOLOGY

Methionine Sulfoxides on Prion Protein Helix-3 Switch on the α-Fold Destabilization Required for Conversion

(2009) Giorgio Colombo et al.   PLoS One

Manganese Enhances Prion Protein Survival in Model Soils and Increases Prion Infectivity to Cells

(2009) Paul Davies et al.   PLoS One

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders

(2009) Ajay Singh et al.   PLoS Pathogens

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms

(2008) Michael A. Cater et al.   BIOCHEMICAL JOURNAL

The Catalytic Core of γ-Secretase: Presenilin Revisited

(2008) Harald Steiner   Current Alzheimer Research

Molecular Mechanisms of Anti-Inflammatory Activity Mediated by Flavonoids

(2008) Ana Gomes et al.   CURRENT MEDICINAL CHEMISTRY

Antioxidant and Iron-Binding Properties of Curcumin, Capsaicin, andS-Allylcysteine Reduce Oxidative Stress in Rat Brain Homogenate

(2008) Amichand Dairam et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Challenges for Research on Polyphenols from Foods in Alzheimer’s Disease: Bioavailability, Metabolism, and Cellular and Molecular Mechanisms

(2008) Manjeet Singh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology

(2008) Sarah L. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Manganese Binding to the Prion Protein

(2008) Marcus W. Brazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change

(2008) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

(2008) Simon C. Drew et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women

(2008) Elizabeth J. Johnson et al.   NUTRITIONAL NEUROSCIENCE

Calcium(II) selectively induces α-synuclein annular oligomers via interaction with the C-terminal domain

(2004) Rachel Lowe et al.   PROTEIN SCIENCE

Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities

(2003) Boon-Seng Wong et al.   JOURNAL OF NEUROCHEMISTRY