Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein

Remote His50 Acts as a Coordination Switch in the High-Affinity N-Terminal Centered Copper(II) Site of α-Synuclein

(2015) Riccardo De Ricco et al.   INORGANIC CHEMISTRY

Differences in the Binding of Copper(I) to α- and β-Synuclein

(2014) Riccardo De Ricco et al.   INORGANIC CHEMISTRY

Site-Specific Copper-Catalyzed Oxidation of α-Synuclein: Tightening the Link between Metal Binding and Protein Oxidative Damage in Parkinson’s Disease

(2014) Marco C. Miotto et al.   INORGANIC CHEMISTRY

Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS–Cu(I) interactions

(2014) Marco C. Miotto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Insights into the Oxygen-Based Ligand of the Low pH Component of the Cu2+-Amyloid-β Complex

(2014) Carlos Z. Gomez-Castro et al.   JOURNAL OF PHYSICAL CHEMISTRY B

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

The Parkinson’s Disease-Associated H50Q Mutation Accelerates α-Synuclein Aggregation in Vitro

(2013) Dhiman Ghosh et al.   BIOCHEMISTRY

Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates

(2013) Alexander S. Maltsev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

Structural Models for Cu(II) Bound to the Fragment 92–96 of the Human Prion Protein

(2012) Rafael Grande-Aztatzi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Spectroscopic and Electronic Structure Studies of Copper(II) Binding to His111 in the Human Prion Protein Fragment 106−115: Evaluating the Role of Protons and Methionine Residues

(2011) Lina Rivillas-Acevedo et al.   INORGANIC CHEMISTRY

Important Role of Oxidative Stress Biomarkers in Huntington’s Disease

(2011) Isaac Túnez et al.   JOURNAL OF MEDICINAL CHEMISTRY

The A53T Mutation is Key in Defining the Differences in the Aggregation Kinetics of Human and Mouse α-Synuclein

(2011) Lijuan Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of His-50 of α-synuclein in binding Cu(ii): pH dependence, speciation, thermodynamics and structure

(2011) Daniela Valensin et al.   Metallomics

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioinorganic Chemistry of Parkinson’s Disease: Structural Determinants for the Copper-Mediated Amyloid Formation of Alpha-Synuclein

(2010) Andrés Binolfi et al.   INORGANIC CHEMISTRY

Evidence for Copper-dioxygen Reactivity during α-Synuclein Fibril Formation

(2010) Heather R. Lucas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploring the Structural Details of Cu(I) Binding to α-Synuclein by NMR Spectroscopy

(2010) Andres Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions

(2009) Wenbo Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A MinMax self-consistent-field approach for auxiliary density functional theory

(2009) Andreas M. Köster et al.   JOURNAL OF CHEMICAL PHYSICS

Site-Specific Interactions of Cu(II) with α and β-Synuclein: Bridging the Molecular Gap between Metal Binding and Aggregation

(2008) Andrés Binolfi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative Stress and Neurotoxicity

(2007) Lawrence M. Sayre et al.   CHEMICAL RESEARCH IN TOXICOLOGY