Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers

Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity

(2016) Huy T. Lam et al.   BIOCHEMISTRY

Membrane-bound tetramer and trimer Aβ oligomeric species correlate with toxicity towards cultured neurons

(2016) Metta K. Jana et al.   JOURNAL OF NEUROCHEMISTRY

An Efficient Procedure for Removal and Inactivation of Alpha-Synuclein Assemblies from Laboratory Materials

(2016) Luc Bousset et al.   Journal of Parkinsons Disease

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology

(2015) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome

(2015) Lan Ye et al.   BRAIN PATHOLOGY

 -synuclein assemblies sequester neuronal  3-Na+/K+-ATPase and impair Na+ gradient

(2015) A. N. Shrivastava et al.   EMBO JOURNAL

Prion Infectivity Plateaus and Conversion to Symptomatic Disease Originate from Falling Precursor Levels and Increased Levels of Oligomeric PrPScSpecies

(2015) Charles E. Mays et al.   JOURNAL OF VIROLOGY

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice

(2015) Nicola J. Rutherford et al.   Molecular Neurodegeneration

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease

(2015) Yen Ying Lim et al.   NEUROBIOLOGY OF AGING

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Propagation of prions causing synucleinopathies in cultured cells

(2015) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

(2015) Stanley B. Prusiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

(2015) M Halliday et al.   Cell Death & Disease

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

(2015) Paula Garcia-Esparcia et al.   Acta Neuropathologica Communications

Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?

(2015) Shynrye Lee et al.   Experimental Neurobiology

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration

(2015) Maddalena Costanzo et al.   BIOCHEMICAL JOURNAL

Aβ seeds resist inactivation by formaldehyde

(2014) Sarah K. Fritschi et al.   ACTA NEUROPATHOLOGICA

Erratum to: Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

(2014) Amanda N. Sacino et al.   ACTA NEUROPATHOLOGICA

Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid

(2014) Sarah K. Fritschi et al.   BRAIN

The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease

(2014) Angelique Camilleri et al.   CNS Neuroscience & Therapeutics

Acceleration of α-Synuclein Aggregation by Exosomes

(2014) Marie Grey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-amyloid Compounds Inhibit α-Synuclein Aggregation Induced by Protein Misfolding Cyclic Amplification (PMCA)

(2014) Maria Eugenia Herva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target

(2014) Brandon B. Holmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Factors Contribute to the Peripheral Induction of Cerebral  -Amyloidosis

(2014) Y. S. Eisele et al.   JOURNAL OF NEUROSCIENCE

Peripheral Administration of a Humanized Anti-PrP Antibody Blocks Alzheimer's Disease A  Synaptotoxicity

(2014) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Brain Injection of  -Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker

(2014) A. N. Sacino et al.   JOURNAL OF NEUROSCIENCE

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease

(2014) Y Y Lim et al.   MOLECULAR PSYCHIATRY

Amyloid and APOE  4 interact to influence short-term decline in preclinical Alzheimer disease

(2014) E. C. Mormino et al.   NEUROLOGY

Aggregate-Depleted Brain Fails to Induce Aβ Deposition in a Mouse Model of Alzheimer's Disease

(2014) Claudia Duran-Aniotz et al.   PLoS One

Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

(2014) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serial propagation of distinct strains of A  prions from Alzheimer's disease patients

(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked

(2014) Malin K. Sandberg et al.   Nature Communications

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

(2014) Hien T. Tran et al.   Cell Reports

Pathological alpha-synuclein propagates through neural networks

(2014) Masami Masuda-Suzukake et al.   Acta Neuropathologica Communications

Alpha-synuclein spreading in M83 mice brain revealed by detection of pathological α-synuclein by enhanced ELISA

(2014) Dominique Bétemps et al.   Acta Neuropathologica Communications

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

(2013) Jens Wagner et al.   ACTA NEUROPATHOLOGICA

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice

(2013) Götz Heilbronner et al.   EMBO REPORTS

Transmission of multiple system atrophy prions to transgenic mice

(2013) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

(2013) J. A. Moreno et al.   Science Translational Medicine

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Evaluation of Potential Infectivity of Alzheimer and Parkinson Disease Proteins in Recipients of Cadaver-Derived Human Growth Hormone

(2013) David J. Irwin et al.   JAMA Neurology

Correlation of Specific Amyloid-β Oligomers With Tau in Cerebrospinal Fluid From Cognitively Normal Older Adults

(2013) Maureen Handoko et al.   JAMA Neurology

Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo

(2013) Claudia Duran-Aniotz et al.   Acta Neuropathologica Communications

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

(2013) Amanda N Sacino et al.   Acta Neuropathologica Communications

APP mutations in the Aβ coding region are associated with abundant cerebral deposition of Aβ38

(2012) Maria Luisa Moro et al.   ACTA NEUROPATHOLOGICA

Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells

(2012) Laura Pieri et al.   BIOPHYSICAL JOURNAL

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly neurotoxic monomeric  -helical prion protein

(2012) M. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain

(2011) Tsuyoshi Hamaguchi et al.   ACTA NEUROPATHOLOGICA

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

(2011) Rebecca F. Rosen et al.   JOURNAL OF NEUROCHEMISTRY

Soluble A  Seeds Are Potent Inducers of Cerebral  -Amyloid Deposition

(2011) F. Langer et al.   JOURNAL OF NEUROSCIENCE

Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice

(2011) M. Cisse et al.   JOURNAL OF NEUROSCIENCE

Modelling of Parkinson's disease in mice

(2011) Marie-Françoise Chesselet et al.   LANCET NEUROLOGY

De novo induction of amyloid-β deposition in vivo

(2011) R Morales et al.   MOLECULAR PSYCHIATRY

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

(2011) Malin K. Sandberg et al.   NATURE

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant prion protein induces a new transmissible prion disease in wild-type animals

(2010) Natallia Makarava et al.   ACTA NEUROPATHOLOGICA

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

(2010) Jessica M. Mc Donald et al.   BRAIN

Prion protein and Aβ-related synaptic toxicity impairment

(2010) Anna Maria Calella et al.   EMBO Molecular Medicine

Aβ42 Neurotoxicity Is Mediated by Ongoing Nucleated Polymerization Process Rather than by Discrete Aβ42 Species

(2010) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SDS-Induced Fibrillation of α-Synuclein: An Alternative Fibrillation Pathway

(2010) Lise Giehm et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid  -Protein Dimers Rapidly Form Stable Synaptotoxic Protofibrils

(2010) B. O'Nuallain et al.   JOURNAL OF NEUROSCIENCE

The prion protein as a receptor for amyloid-β

(2010) Helmut W. Kessels et al.   NATURE

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein, lipids and Parkinson’s disease

(2010) Violeta Ruipérez et al.   PROGRESS IN LIPID RESEARCH

Darwinian Evolution of Prions in Cell Culture

(2010) J. Li et al.   SCIENCE

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Fatal Transmissible Amyloid Encephalopathy: A New Type of Prion Disease Associated with Lack of Prion Protein Membrane Anchoring

(2010) Bruce Chesebro et al.   PLoS Pathogens

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology

(2009) Karin M. Danzer et al.   JOURNAL OF NEUROCHEMISTRY

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Mutation I810N in the  3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS

(2009) S. J. Clapcote et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of cerebral  -amyloidosis: Intracerebral versus systemic A  inoculation

(2009) Y. S. Eisele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De Novo Generation of Infectious Prions In Vitro Produces a New Disease Phenotype

(2009) Marcelo A. Barria et al.   PLoS Pathogens

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

(2008) Ivar Mendez et al.   NATURE MEDICINE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Introduction

(2008) J. Collinge et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES