Expression of mutant alpha-synuclein modulates microglial phenotype in vitro

Suppressed Accumulation of Cerebral Amyloid β Peptides in Aged Transgenic Alzheimer’s Disease Mice by Transplantation with Wild-Type or Prostaglandin E2 Receptor Subtype 2-Null Bone Marrow

(2010) C. Dirk Keene et al.   AMERICAN JOURNAL OF PATHOLOGY

α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

(2010) Frédéric Darios et al.   EMBO REPORTS

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Identification of the amino acid sequence motif of α-synuclein responsible for macrophage activation

(2009) Saet-byul Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

(2009) Adam J. Trexler et al.   BIOCHEMISTRY

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   BIOCHEMISTRY

Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling

(2009) Alexandra I. Medeiros et al.   JOURNAL OF EXPERIMENTAL MEDICINE

α-Synuclein induces migration of BV-2 microglial cells by up-regulation of CD44 and MT1-MMP

(2009) Seonghan Kim et al.   JOURNAL OF NEUROCHEMISTRY

Subchronic infusion of the product of inflammation prostaglandin J2 models sporadic Parkinson's disease in mice

(2009) Sha-Ron Pierre et al.   Journal of Neuroinflammation

Kinetics of Microglial Activation and Degeneration of Dopamine-Containing Neurons in a Rat Model of Parkinson Disease Induced by 6-Hydroxydopamine

(2009) Vincent Henry et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The role of α-synuclein in brain lipid metabolism: a downstream impact on brain inflammatory response

(2009) Mikhail Y. Golovko et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Effects of chronic low dose rotenone treatment on human microglial cells

(2009) Shamim B Shaikh et al.   Molecular Neurodegeneration

Brain Arachidonic Acid Cascade Enzymes are Upregulated in a Rat Model of Unilateral Parkinson Disease

(2009) Ho-Joo Lee et al.   NEUROCHEMICAL RESEARCH

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

(2009) Xiaomin Su et al.   NEUROTOXICITY RESEARCH

Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson

(2008) Piotr Zabrocki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Microglial phagocytosis is enhanced by monomeric α-synuclein, not aggregated α-synuclein: Implications for Parkinson's disease

(2008) Ji-Young Park et al.   GLIA

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cyclooxygenase-2 is involved in oxidative damage and alpha-synuclein accumulation in dopaminergic cells

(2008) Sung-Wook Chae et al.   NEUROSCIENCE LETTERS

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

(2008) Shaik Shavali et al.   NEUROSCIENCE LETTERS

Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcγ-receptor-mediated phagocytosis in alveolar macrophages

(2007) Thomas G. Brock et al.   EXPERIMENTAL CELL RESEARCH

Glial reactions in Parkinson's disease

(2007) Patrick L. McGeer et al.   MOVEMENT DISORDERS

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING

Brain prostaglandin formation is increased by α-synuclein gene-ablation during global ischemia

(2007) Mikhail Y. Golovko et al.   NEUROSCIENCE LETTERS

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING