Article
Behavioral Sciences
Ewa Zwierzynska, Boguslawa Pietrzak
Summary: Lacosamide does not impair memory and learning processes, with temporary disruption of emotional memory observed only after a single high dose administration.
EPILEPSY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Bettina Reka Laszlo, Erika Kertes, Tamas Ollmann, Laszlo Peczely, Anita Kovacs, Zoltan Karadi, Laszlo Lenard, Kristof Laszlo
Summary: The neurotransmitter and neuromodulator neurotensin (NT) has been found to facilitate spatial learning and memory through the activation of DA D2 receptors in the central nucleus of amygdala (CeA).
Article
Plant Sciences
Mohsen Naseri, Reza Arabi Mianroodi, Zeynab Pakzad, Peyman Falahati, Masomeh Borbor, Hossein Azizi, Sima Nasri
Summary: The study showed that Melissa officinalis extract can improve learning and memory in diabetic rats, possibly by increasing the expression of brain-derived neurotrophic factor and nitric oxide synthase genes.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lih-Geeng Chen, Shyr-Yi Lin, Yi-Shan Lee, Ching-Chiung Wang, Wen-Chi Hou
Summary: Agricultural waste from water caltrop hulls was extracted and shown to have AChE inhibitory activities, free radical scavenging activities, and anti-non-enzymatic protein glycation effects. Several compounds with strong AChE inhibitory activities and anti-amyloid 13 peptide aggregation effects were identified. Additionally, treatment with the extracted compounds or water caltrop hull extracts improved learning behavior in mice with induced amnesia.
Article
Nutrition & Dietetics
Nosheen Malik, Sana Javaid, Waseem Ashraf, Farhan Siddique, Muhammad Fawad Rasool, Faleh Alqahtani, Tanveer Ahmad, Muhammad Asad Abrar, Imran Imran
Summary: The medicinal properties of Syzygium cumini and its effects on age-related neurological changes have been explored in this study. Supplementing young mice with Syzygium cumini fruit pulp has shown significant protection against anxiety-like behavior and improved cognitive abilities in aged mice. The beneficial effects may be attributed to the antioxidant and anticholinergic effects of the phytocompounds present in Syzygium cumini.
Article
Behavioral Sciences
Radharani Benvenutti, Matheus Marcon, Matheus Gallas-Lopes, Anna Julie de Mello, Ana Paula Herrmann, Angelo Piato
Summary: Zebrafish is emerging as an alternative model organism for studying neurobiological mechanisms of various behaviors, including anxiety, preference, learning, and memory, relevant to neuropsychiatric disorders. However, the wide variation in protocols and apparatus shapes and dimensions for maze studies in zebrafish literature poses challenges to reproducibility across institutions. This review aims to provide an overview of the behavioral paradigms assessed in different types of mazes in zebrafish and contribute to a better characterization of multi-behavioral assessment in zebrafish.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Food Science & Technology
Chi Heung Cho, Young Sung Jung, Jong Min Kim, Tae Gyu Nam, Sang-Hoon Lee, Hye Sung Cho, Myoung Chong Song, Ho Jin Heo, Dae-Ok Kim
Summary: The Actinidia eriantha cv. Bidan extract (AEE) showed neuroprotective effects by reducing reactive oxygen species levels and suppressing apoptotic cell death, resulting in improvements in learning and spatial memory in Aβ1-42-treated mice. AEE also increased endogenous antioxidant systems in mouse brain tissue and contained caffeic acid derivatives, suggesting its potential to improve cognitive function as a source of antioxidant phenolics.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Sabiheh Amirahmadi, Faezeh Dabouri Farimani, Mahsan Akbarian, Farshad Mirzavi, Mohammad Hossein Eshaghi Ghalibaf, Arezoo Rajabian, Mahmoud Hosseini
Summary: This study demonstrates that minocycline improves memory dysfunction by regulating the cholinergic system, oxidative stress balance, and inhibiting inflammatory responses.
INFLAMMOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Liang Li, Chunhai Zhang
Summary: Post-operative cognitive dysfunction (POCD) is a common complication after surgery, exposure to general anesthetics can induce increased expression of GABA(A) receptor subunit alpha 5 and inflammatory cytokines in the brain. Venlafaxine (VLX) may be a promising candidate for the treatment of POCD, as it can reduce the expression levels of alpha 5 subunit and inflammatory cytokines in the brain.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Applied
Lidia Baltina, Tatyana Sapozhnikova, Nina Makara, Svetlana Gabdrakhmanova, Lia Baltina, Rimma Kondratenko
Summary: Chemical modification of paeoniflorin was found to affect the cognitive functions of aged rats. Introduction of C4 = O function into the benzoate part improved the learning process and preserved memory trace in aged rats, showing promise for further studies on disorders characteristic of Alzheimer's disease.
NATURAL PRODUCT RESEARCH
(2021)
Article
Behavioral Sciences
Ericks Sousa Soares, Felipe Vanz, Vagner Fagnani Linartevichi, Helena Cimarosti, Thereza Christina Monteiro de Lima
Summary: Memory is the ability to store, retrieve and use information, and it relies on a time-dependent consolidation process. The hippocampus plays a crucial role in processing all types of information, particularly spatial memory. This study investigates the involvement and recruitment of neuropeptide Y (NPY) receptors in the consolidation of spatial memory. The results demonstrate that NPY injection impairs memory consolidation, and previous stress enhances this effect. Additionally, selective antagonists for NPY receptors Y-1 and Y-2 show that both receptors are key players in spatial memory consolidation. The findings suggest that NPY modulates aversive and adaptive memory formation through receptor activation.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marta Kruk-Slomka, Grazyna Biala
Summary: Schizophrenia is a chronic mental disorder that disturbs feelings and behavior. Research on the potential of cannabidiol (CBD) in treating memory impairment associated with cognitive symptoms of schizophrenia has shown positive effects in memory and learning processes in mice. CBD has been found to attenuate memory impairment caused by hypofunction of glutamate transmission in a murine model of schizophrenia.
Article
Environmental Sciences
Hristina Ivanova Zlatanova, Maria Todorova Georgieva-Kotetarova, Natalia Borisova Vilmosh, Ilin Kostadinov Kandilarov
Summary: This study evaluated the therapeutic effects of cariprazine on memory impairment and found that it can improve learning, recognition, and spatial memory in rats. The drug's beneficial effects on cognition are likely mediated by its affinity for D3 receptors and agonism at 5-HT1A receptors, resulting in integrated modulation in the amygdala, hippocampus, and prefrontal cortex.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Vandana Veenit, Xiaoqun Zhang, Wojciech Paslawski, Ioannis Mantas, Per Svenningsson
Summary: This study reveals the important role of GPR37L1 gene in emotional behaviors and physiological mechanisms in mice, particularly in aversive learning processes. Lack of GPR37L1 also leads to increased body weight and alterations in related biochemical markers, with age- and sex-specific effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Ingrid Marguerite Wagnon, Lillian Jocelyn Jabur, Garry Niedermayer, Gerald Muench, Tim Karl, Rose Chesworth, Erika Gyengesi
Summary: In this study, the neuroinflammatory mechanisms in female mice were investigated using the GFAP-IL6 mouse model. The results showed that female GFAP-IL6 mice exhibited reduced anxiety-like behavior and hypolocomotion, as well as impairment in short-term memory. Furthermore, gene expression analysis revealed neuroinflammation and dysregulation of neurotransmission in certain brain regions of GFAP-IL6 mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Hasan Yousefi-Manesh, Samira Shirooie, Tayebeh Noori, Seyed Mohammad Tavangar, Mohammad Sheibani, Alireza Chaboki, Sina Mohammadi, Ahmad Reza Dehpour
Summary: Sepsis is a severe systemic inflammatory response with high mortality rate caused by different microorganisms. Sumatriptan, a 5-HT1B/1D agonist, has anti-inflammatory and anti-oxidative stress effects, showing significant protection in sepsis-induced inflammatory cytokines and survival rate.
Article
Surgery
Armin Aryannejad, Faezeh Eslami, Maryam Shayan, Nafise Noroozi, Keshvad Hedayatyanfard, Seyed Mohammad Tavangar, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: This study aimed to evaluate the efficacy of CBD on random-pattern skin flap survival in rats and explore the involvement of CB2 receptors. The results showed that pretreatment with CBD significantly improved flap survival in rats and exerted desirable anti-inflammatory effects, possibly mediated by CB2 receptors.
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2023)
Article
Pharmacology & Pharmacy
Sanaz Mokhtari, Neda Sistani Karampour, Mohammad-Hossein Shams, Ahmad Reza Dehpour, Amin Hasanvand
Summary: Progesterone has anti-inflammatory and antioxidative effects and protects against diabetic neuropathy. Treatment with progesterone reduces neuropathic sensitivity, inflammation, and edema, while improving nerve conduction velocity and reducing oxidative stress and inflammatory factors.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Food Science & Technology
Ramin Goudarzi, Golnaz Zamanian, Zahra Seyyedian, Partow Mirzaee Saffari, Ahmad Reza Dehpour, Alireza Partoazar
Summary: This study evaluated the anti-inflammatory effect of arthrocen, avocado/soybean unsaponifiables (ASU), in improving poststroke complications like depression in a mice model. The results showed that arthrocen had significant antidepressant-like effects and reduced the production of proinflammatory cytokines in the ischemic brain hippocampus. Moreover, arthrocen increased the number of viable neurons in the stroke mice. These findings suggest that arthrocen has potential as a treatment for poststroke depression by reducing inflammation and protecting neural cells.
FOOD SCIENCE & NUTRITION
(2023)
Article
Behavioral Sciences
Mohammad Amin Sadeghi, Sara Hemmati, Hasan Yousefi-Manesh, Saba Fekrvand, Laleh Foroutani, Ehsan Nassireslami, Mojtaba Yousefi Zoshk, Yasaman Hosseini, Ahmad Reza Dehpour, Mohsen Chamanara
Summary: Combining subchronic fluoxetine with selective nNOS inhibitor 7-nitroindazole accelerated the efficacy of fluoxetine in treating post-traumatic stress disorder, and hippocampal activity showed biphasic correlation with anxiety-related behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sina Jourian, Mohammad Rahimi, Mohammad Amin Manavi, Mohammad-Taha Pahlevan-Fallahy, Razieh Mohammad Jafari, Ali Amini, Ahmad Reza Dehpour
Summary: This study found that ivermectin has an anticonvulsant effect on clonic seizure threshold. Furthermore, the anticonvulsant effect of ivermectin may be mediated through the interaction of the opioidergic system and the nitric oxide pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Maryam Shayan, Faezeh Eslami, Ayda Khosravi, Amir Rashidian, Razie Mohammad Jafari, Seyed Farzad Maroufi, Hasti Tashak Golroudbari, Ahmad Reza Dehpour
Summary: This study found that cyclosporine, ondansetron, and tropisetron have neuroprotective effects against optic nerve crush injury in rats, possibly through the suppression of apoptosis and modulation of calcineurin activity directly and via 5-HT3 receptors.
Article
Pharmacology & Pharmacy
Aysa Ostovaneh, Faezeh Eslami, Nastaran Rahimi, Pegah Dejban, Hamed Shafaroodi, Ata Abbasi, Shirin Shahsavarhaghighi, Ahmad Reza Dehpour
Summary: This study investigated the beneficial effect of sumatriptan in rats with gastric ulcer by stimulating 5HT(1B/1D) receptors and suppressing pro-inflammatory cytokines. Sumatriptan significantly improved gastric injury induced by different ulcer models, suggesting its gastroprotective effects through the involvement of 5HT(1B/1D) receptors.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hasan Yousefi-Manesh, Samira Shirooie, Tayebeh Noori, Mohammad Sheibani, Seyed Mohammad Tavangar, Sara Hemmati, Mohammad Amin Sadeghi, Hassan Akbarniakhaky, Zohreh Mohammadi, Laleh Foroutani, Ahmad Reza Dehpour
Summary: English summary: The study investigates the effects of spermidine on oxidative stress markers and pain threshold in a rat model of chronic constriction injury. The findings suggest that spermidine treatment can alleviate neuropathic pain by reducing oxidative stress and improving pathological changes.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Arya Afrooghe, Mohammadreza Babaei, Maryam Shayan, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad-Reza Dehpour
Summary: Itching is an unpleasant sensation on the skin that affects the quality of life. Bromhexine, derived from Adhatoda vasica, has been found to alleviate acute itch by inhibiting TMPRSS2 and reducing KP activation. Administering 1-Methyl Tryptophan, an IDO inhibitor, also reduces itching. The combined use of bromhexine and 1-MT results in synergistic antipruritic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Moein Ala, Mohammad Reza Fallahpour Khoshdel, Razieh Mohammad Jafari, Mehrdokht Sadrkhanloo, Sepideh Goudarzi, Meisam Asl Soleimani, Ahmad Reza Dehpour
Summary: In this study, it was found that sumatriptan has protective effects against mesenteric ischemia and the inhibition of the kynurenine pathway may be involved in this process. Therefore, sumatriptan has the potential to be repurposed as a treatment for acute mesenteric ischemia.
PHARMACOLOGICAL REPORTS
(2023)
Review
Surgery
Arya Afrooghe, Amirmasoud Rayati Damavandi, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Summary: The incorporation of skin flaps in wound closure management has shown promise in achieving desirable cosmetic outcomes. However, skin flaps are prone to complications, such as ischemia-reperfusion injury (IRI), due to various factors. Numerous approaches have been attempted to enhance skin flap survival, including pre/post-conditioning with surgical and pharmacological methods. These approaches utilize cellular and molecular mechanisms to reduce inflammation, promote angiogenesis, induce apoptosis and autophagy. The emerging role of stem cells in improving skin flap viability has led to the development of more translational methods. This review aims to provide current evidence on these approaches.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Medicine, General & Internal
Arash Amanlou, Ehsan Nassireslami, Ahmad Reza Dehpour, Amir Rashidian, Mohsen Chamanara
Summary: Seizures and epilepsy have a severe impact on the quality of life for those affected. This review examines the effect of statins on the prevention and treatment of seizures and epilepsy using both animal models and human studies. It discusses the mechanisms of action, side effects, and comparison of different types of statins in relation to seizures. This review provides valuable insights for researchers to clarify the beneficial effects of statins on neurological disorders.
IRANIAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mahla Masoumi, Mohammad Amin Manavi, Razieh Mohammad Jafari, Alireza Mirzaei, Keshvad Hedayatyanfard, Mohammad Taghi Beigmohammadi, Ahmad Reza Dehpour
Summary: This study investigated the anticonvulsant effects of CBD on lithium-pilocarpine-induced SE in rats and found a possible involvement of CB1 receptors and anti-inflammatory effects. The results suggest that CBD may have therapeutic potential for SE, independent of CB2 and GABA(A) receptors.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ahmad Reza Dehpour, Ehsan Khaledi, Tayebeh Noori, Ahmad Mohammadi-Farani, Ladan Delphi, Antoni Sureda, Eduardo Sobarzo-Sanchez, Samira Shirooie
Summary: This study assessed the effects of Dapsone on behavioral dysfunction and myelin preservation in a cuprizone-induced demyelination model. The results showed that Dapsone improved demyelination and reduced behavioral abnormalities through targeting Nrf2 and NF-kB pathways.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)