Vaccination strategies for Parkinson disease

Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials

(2014) Markus Mandler et al.   ACTA NEUROPATHOLOGICA

Cytokine Gene Polymorphisms and Parkinson's Disease: A Meta-Analysis

(2014) Chu Ketan et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

(2013) Vanesa Sanchez-Guajardo et al.   ASN Neuro

Dopamine Receptor D3 Expressed on CD4+ T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease

(2013) H. Gonzalez et al.   JOURNAL OF IMMUNOLOGY

The Different Clinical Effects of Anti-BLyS, Anti-APRIL and Anti-CD20 Antibodies Point at a Critical Pathogenic Role of γ-Herpesvirus Infected B Cells in the Marmoset EAE Model

(2013) S. Anwar Jagessar et al.   Journal of Neuroimmune Pharmacology

GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice

(2013) Lisa M. Kosloski et al.   JOURNAL OF NEUROIMMUNOLOGY

α-Synuclein Vaccination Prevents the Accumulation of Parkinson Disease-Like Pathologic Inclusions in Striatum in Association With Regulatory T Cell Recruitment in a Rat Model

(2013) Vanesa Sanchez-Guajardo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Bacillus Calmette-Guerin vaccine-mediated neuroprotection is associated with regulatory T-cell induction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

(2013) Goran Laćan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies

(2013) Elvira Valera et al.   PHARMACOLOGY & THERAPEUTICS

Natural IgG Autoantibodies Are Abundant and Ubiquitous in Human Sera, and Their Number Is Influenced By Age, Gender, and Disease

(2013) Eric P. Nagele et al.   PLoS One

Inflammation and Adaptive Immunity in Parkinson's Disease

(2013) R. L. Mosley et al.   Cold Spring Harbor Perspectives in Medicine

The Primate EAE Model Points at EBV-Infected B Cells as a Preferential Therapy Target in Multiple Sclerosis

(2013) Bert A. ‘T Hart et al.   Frontiers in Immunology

Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein

(2012) Eun-Jin Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuro-protective effects of bee venom by suppression of neuroinflammatory responses in a mouse model of Parkinson’s disease: Role of regulatory T cells

(2012) Eun Sook Chung et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammatory cytokines and NT-proCNP in Parkinson’s disease patients

(2012) Dariusz Koziorowski et al.   CYTOKINE

Dopaminergic therapies modulate the T-CELL proteome of patients with Parkinson's disease

(2012) Tiziana Alberio et al.   IUBMB LIFE

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

(2012) C. Prado et al.   JOURNAL OF IMMUNOLOGY

Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?

(2012) Marco Cosentino et al.   Journal of Neuroimmune Pharmacology

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

Reduced T helper and B lymphocytes in Parkinson's disease

(2012) Claire H. Stevens et al.   JOURNAL OF NEUROIMMUNOLOGY

Impact of intravenous immunoglobulin on the dopaminergic system and immune response in the acute MPTP mouse model of Parkinson’s disease

(2012) Isabelle St-Amour et al.   Journal of Neuroinflammation

Antibody-Aided Clearance of Extracellular  -Synuclein Prevents Cell-to-Cell Aggregate Transmission

(2012) E.-J. Bae et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic Modulation of CD4+CD25high Regulatory T Lymphocytes in Multiple Sclerosis Patients during Interferon-ß Therapy

(2012) Marco Cosentino et al.   NEUROIMMUNOMODULATION

Naturally occurring  -synuclein autoantibody levels are lower in patients with Parkinson disease

(2012) D. Besong-Agbo et al.   NEUROLOGY

Non-Motor Symptoms in Patients with Parkinson’s Disease – Correlations with Inflammatory Cytokines in Serum

(2012) Daniel Lindqvist et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra

(2012) A L McCormack et al.   Cell Death & Disease

Immunology, Autoimmunity, and Autoantibodies in Parkinson’s Disease

(2011) Michal Benkler et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Parkinson’s disease is associated with increased serum levels of macrophage migration inhibitory factor

(2011) Alessandra Nicoletti et al.   CYTOKINE

The duality of TNF signaling outcomes in the brain: Potential mechanisms?

(2011) Christopher J. Barnum et al.   EXPERIMENTAL NEUROLOGY

Pathways towards an effective immunotherapy for Parkinson’s disease

(2011) Jessica AL Hutter-Saunders et al.   Expert Review of Neurotherapeutics

Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson's disease

(2011) Fumitoshi Niwa et al.   Geriatrics & Gerontology International

Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder

(2011) Thais B. Ferreira et al.   JOURNAL OF NEUROIMMUNOLOGY

Immunoprotection against toxic biomarkers is retained during Parkinson's disease progression

(2011) Marina A. Gruden et al.   JOURNAL OF NEUROIMMUNOLOGY

Serum Levels of Chemokines in Parkinson’s Disease

(2011) Paula Scalzo et al.   NEUROIMMUNOMODULATION

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Vaccination for Parkinson's disease

(2011) A. Schneeberger et al.   PARKINSONISM & RELATED DISORDERS

BCG Vaccine-Induced Neuroprotection in a Mouse Model of Parkinson's Disease

(2011) Jing Yong et al.   PLoS One

α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease Patients

(2011) Kiran Yanamandra et al.   PLoS One

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Diagnosis of Alzheimer's Disease Based on Disease-Specific Autoantibody Profiles in Human Sera

(2011) Eric Nagele et al.   PLoS One

A novel molecular mechanism for nitrated α-synuclein-induced cell death

(2011) Yanying Liu et al.   Journal of Molecular Cell Biology

Short communication Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's disease

(2010) T. Müller et al.   ACTA NEUROLOGICA SCANDINAVICA

Parkinson's disease and immunological abnormalities: increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in peripheral blood

(2010) U. Fiszer et al.   ACTA NEUROLOGICA SCANDINAVICA

The role of antibodies in multiple sclerosis

(2010) Martin S. Weber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

An Association between Immunosenescence and CD4+CD25+ Regulatory T cells: A Systematic Review

(2010) Ling WANG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Brain-reactive autoantibodies are nearly ubiquitous in human sera and may be linked to pathology in the context of blood–brain barrier breakdown

(2010) Eli C. Levin et al.   BRAIN RESEARCH

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Regulation of immunity and autoimmunity by B cells

(2010) Claudia Mauri   CURRENT OPINION IN IMMUNOLOGY

Therapy with anti-TNFα antibody enhances number and function of Foxp3+ regulatory T cells in inflammatory bowel diseases

(2010) Gilles Boschetti et al.   INFLAMMATORY BOWEL DISEASES

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

GM-CSF-induced, bone-marrow-derived dendritic cells can expand natural Tregs and induce adaptive Tregs by different mechanisms

(2010) Palash Bhattacharya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A case for regulatory B cells in controlling the severity of autoimmune-mediated inflammation in experimental autoimmune encephalomyelitis and multiple sclerosis

(2010) Avijit Ray et al.   JOURNAL OF NEUROIMMUNOLOGY

Augmentation of regulatory B cell activity in experimental allergic encephalomyelitis by glatiramer acetate

(2010) Sakhina Begum-Haque et al.   JOURNAL OF NEUROIMMUNOLOGY

B cells in spontaneous autoimmune diseases of the central nervous system

(2010) Kerstin Berer et al.   MOLECULAR IMMUNOLOGY

Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

(2010) Ashley S Harms et al.   MOLECULAR THERAPY

When does Parkinson's disease begin?

(2010) Carles Gaig et al.   MOVEMENT DISORDERS

Peripheral expression of key regulatory kinases in Alzheimer's disease and Parkinson's disease

(2010) M.T. Armentero et al.   NEUROBIOLOGY OF AGING

Apoptosis of peripheral blood lymphocytes in Parkinson patients

(2010) Màtil Calopa et al.   NEUROBIOLOGY OF DISEASE

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One

Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats

(2010) Zhongwang Yu et al.   PLoS One

Circulating interleukin-10 and interleukin-12 in Parkinson’s disease

(2009) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Innate and Adaptive Immunity for the Pathobiology of Parkinson's Disease

(2009) David K. Stone et al.   ANTIOXIDANTS & REDOX SIGNALING

The immunoregulatory role of dopamine: An update

(2009) Chandrani Sarkar et al.   BRAIN BEHAVIOR AND IMMUNITY

Transcriptional regulatory networks in Th17 cell differentiation

(2009) Liang Zhou et al.   CURRENT OPINION IN IMMUNOLOGY

The TNF superfamily in 2009: new pathways, new indications, and new drugs

(2009) Malú G. Tansey et al.   DRUG DISCOVERY TODAY

Granulocyte-macrophage colony-stimulating factor promotes survival of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced murine Parkinson’s disease model

(2009) Na K. Kim et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Anti-melanin antibodies are increased in sera in Parkinson's disease

(2009) K.L. Double et al.   EXPERIMENTAL NEUROLOGY

Roles of B lymphocytes in multiple sclerosis: diversifying beyond the antibody response

(2009) Paulo Fontoura   Immunotherapy

Dopamine released by dendritic cells polarizes Th2 differentiation

(2009) K. Nakano et al.   INTERNATIONAL IMMUNOLOGY

Nitrated  -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

(2009) A. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Role of dopamine in the physiology of T-cells and dendritic cells

(2009) Rodrigo Pacheco et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased serum levels of soluble tumor necrosis factor-α receptor-1 in patients with Parkinson's disease

(2009) Paula Scalzo et al.   JOURNAL OF NEUROIMMUNOLOGY

Interleukin-6 Serum Levels in Patients with Parkinson’s Disease

(2009) Kerly Wollmeister Hofmann et al.   NEUROCHEMICAL RESEARCH

Serum levels of interleukin-6 are elevated in patients with Parkinson's disease and correlate with physical performance

(2009) Paula Scalzo et al.   NEUROSCIENCE LETTERS

CXCR4 and CXCL12 Expression is Increased in the Nigro-Striatal System of Parkinson’s Disease

(2009) Mika Shimoji et al.   NEUROTOXICITY RESEARCH

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

Peripheral cytokines profile in Parkinson’s disease

(2008) M. Reale et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors

(2008) Mia Levite   CURRENT OPINION IN PHARMACOLOGY

Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

(2008) Christophe Lo Bianco et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuroinflammation and Oxidation/Nitration of  -Synuclein Linked to Dopaminergic Neurodegeneration

(2008) H.-M. Gao et al.   JOURNAL OF NEUROSCIENCE

B cells and multiple sclerosis

(2008) Diego Franciotta et al.   LANCET NEUROLOGY

Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats

(2008) Melissa K McCoy et al.   MOLECULAR THERAPY

Antineuronal antibodies in Parkinson's disease

(2008) Bart P.C. van de Warrenburg et al.   MOVEMENT DISORDERS

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS

Increased oxidative stress in lymphocytes from untreated Parkinson's disease patients

(2008) Alessandro Prigione et al.   PARKINSONISM & RELATED DISORDERS

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Oxidative-stress-induced apoptosis in PBLs of two patients with Parkinson disease secondary to alpha-synuclein mutation

(2007) Carla Battisti et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES