A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders

PD1 Negative and PD1 Positive CD4+ T Regulatory Cells in Mild Cognitive Impairment and Alzheimer's Disease

(2017) Marina Saresella et al.   JOURNAL OF ALZHEIMERS DISEASE

Therapeutic effects of glatiramer acetate and grafted CD115+monocytes in a mouse model of Alzheimer’s disease

(2015) Yosef Koronyo et al.   BRAIN

Emerging mechanisms of molecular pathology in ALS

(2015) Owen M. Peters et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating brain derived neurotrophic factor (BDNF) and frequency of BDNF positive T cells in peripheral blood in human ischemic stroke: Effect on outcome

(2015) Adeline Chan et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of thymic stimulation of CD4+ T cell expansion on disease onset and progression in mutant SOD1 mice

(2015) Rebecca K Sheean et al.   Journal of Neuroinflammation

Innate immunity in Alzheimer's disease

(2015) Michael T Heneka et al.   NATURE IMMUNOLOGY

Neuroinflammation in Alzheimer’s disease; A source of heterogeneity and target for personalized therapy

(2015) C.H. Latta et al.   NEUROSCIENCE

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

American Academy of Neurology, Washington, 18–25 avril 2015

(2015) I. Sibon et al.   REVUE NEUROLOGIQUE

Response to Letter Regarding Article, “Amplification of Regulatory T Cells Using a CD28 Superagonist Reduces Brain Damage After Ischemic Stroke in Mice”

(2015) Roland Veltkamp et al.   STROKE

Letter by Gauberti and Vivien Regarding Article, “Amplification of Regulatory T Cells Using a CD28 Superagonist Reduces Brain Damage After Ischemic Stroke in Mice”

(2015) Maxime Gauberti et al.   STROKE

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice

(2015) Fei Wang et al.   Oncotarget

Cerebral Amyloid Angiopathy: Emerging Concepts

(2015) Masahito Yamada   Journal of Stroke

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: Boosting autoimmunity to fight-off chronic neuroinflammation

(2014) Michal Schwartz et al.   JOURNAL OF AUTOIMMUNITY

CD28 Superagonist-Mediated Boost of Regulatory T Cells Increases Thrombo-Inflammation and Ischemic Neurodegeneration during the Acute Phase of Experimental Stroke

(2014) Michael K Schuhmann et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis

(2014) Satoru Tada et al.   Journal of Neuroinflammation

Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

(2014) Kristi M Anderson et al.   Translational Neurodegeneration

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

The immune system and aging: a review

(2013) Camil Castelo-Branco et al.   GYNECOLOGICAL ENDOCRINOLOGY

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

(2013) Weihua Zhao et al.   Journal of Neuroimmune Pharmacology

GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice

(2013) Lisa M. Kosloski et al.   JOURNAL OF NEUROIMMUNOLOGY

Proinflammatory Cytokines, Aging, and Age-Related Diseases

(2013) Martin Michaud et al.   Journal of the American Medical Directors Association

Regulation of Neurotropic Signaling by the Inducible, NF-kB-Sensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells

(2013) Yuhai Zhao et al.   MOLECULAR NEUROBIOLOGY

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats

(2013) Maria Nikodemova et al.   NEUROBIOLOGY OF DISEASE

Correction: Transcriptome Analysis of Medicinal Plant Salvia miltiorrhiza and Identification of Genes Related to Tanshinone Biosynthesis

(2013) Lei Yang et al.   PLoS One

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Inflammation and Adaptive Immunity in Parkinson's Disease

(2013) R. L. Mosley et al.   Cold Spring Harbor Perspectives in Medicine

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

Inflammation and neurovascular changes in amyotrophic lateral sclerosis

(2012) M.C. Evans et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology

(2011) Paul G. Ince et al.   ACTA NEUROPATHOLOGICA

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Pathways towards an effective immunotherapy for Parkinson’s disease

(2011) Jessica AL Hutter-Saunders et al.   Expert Review of Neurotherapeutics

MHC-Independent Genetic Factors Control the Magnitude of CD4+ T Cell Responses to Amyloid-  Peptide in Mice through Regulatory T Cell-Mediated Inhibition

(2011) C. Toly-Ndour et al.   JOURNAL OF IMMUNOLOGY

SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer

(2011) R. Thomas et al.   MOLECULAR CANCER THERAPEUTICS

Immunization strategies for Parkinson's disease

(2011) Duy Ha et al.   PARKINSONISM & RELATED DISORDERS

Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway

(2010) Melissa Nassif et al.   ANTIOXIDANTS & REDOX SIGNALING

Immune-Inflammatory Responses and Oxidative Stress in Alzheimers Disease: Therapeutic Implications

(2010) D. Bona et al.   CURRENT PHARMACEUTICAL DESIGN

Low Grade Inflammation as a Common Pathogenetic Denominator in Age-Related Diseases: Novel Drug Targets for Anti-Ageing Strategies and Successful Ageing Achievement

(2010) G. Candore et al.   CURRENT PHARMACEUTICAL DESIGN

Control of neuroinflammation as a therapeutic strategy for amyotrophic lateral sclerosis and other neurodegenerative disorders

(2010) R. Lee Mosley et al.   EXPERIMENTAL NEUROLOGY

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Pathophysiology of Neurodegeneration in Familial Amyotrophic Lateral Sclerosis

(2009) Steve Vucic et al.   CURRENT MOLECULAR MEDICINE

Nitrated  -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets

(2009) A. D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Microglia in ALS: The Good, The Bad, and The Resting

(2009) Jenny S. Henkel et al.   Journal of Neuroimmune Pharmacology

Proteomic Studies of Nitrated Alpha-Synuclein Microglia Regulation by CD4+CD25+ T Cells

(2009) Ashley D. Reynolds et al.   JOURNAL OF PROTEOME RESEARCH

Progress in the Active Immunotherapeutic Approach to Alzheimer’s Disease: Clinical Investigations into AN1792-Associated Meningoencephalitis

(2008) Michael Pride et al.   Neurodegenerative Diseases

Protective autoimmunity in the nervous system

(2008) Jerome J. Graber et al.   PHARMACOLOGY & THERAPEUTICS

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One