Immunometabolism in systemic lupus erythematosus

The effect of immunosuppressive molecules on T-cell metabolic reprogramming

(2016) Ana A. Fernández-Ramos et al.   BIOCHIMIE

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Metabolic Factors that Contribute to Lupus Pathogenesis

(2016) Wei Li et al.   CRITICAL REVIEWS IN IMMUNOLOGY

T follicular helper (Tfh) cells in lupus: Activation and involvement in SLE pathogenesis

(2016) Patrick Blanco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells

(2016) Wing Y. Lam et al.   IMMUNITY

The critical role of epigenetics in systemic lupus erythematosus and autoimmunity

(2016) Hai Long et al.   JOURNAL OF AUTOIMMUNITY

Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know

(2016) Michael Aronov et al.   JOURNAL OF CLINICAL IMMUNOLOGY

HIF1α and metabolic reprogramming in inflammation

(2016) Sarah E. Corcoran et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Fatty Acid Amide Hydrolase Regulates Peripheral B Cell Receptor Revision, Polyreactivity, and B1 Cells in Lupus

(2016) Simanta Pathak et al.   JOURNAL OF IMMUNOLOGY

Coexistence of systemic lupus erythematosus, tuberous sclerosis and aggressive natural killer-cell leukaemia: coincidence or correlated?

(2016) M Olde Bekkink et al.   LUPUS

Coexistence of SLE, tuberous sclerosis and aggressive natural killer-cell leukaemia: Coincidence or correlated?

(2016) S Psarelis et al.   LUPUS

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

(2016) Sung Hoon Cho et al.   NATURE

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol

(2016) Feng Wang et al.   NATURE IMMUNOLOGY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren’s Syndrome and Systemic Sclerosis

(2016) Anders A. Bengtsson et al.   PLoS One

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

(2016) Zhen Yang et al.   Science Translational Medicine

mTOR-Mediated Regulation of Dendritic Cell Differentiation and Function

(2016) Nyamdelger Sukhbaatar et al.   TRENDS IN IMMUNOLOGY

Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years

(2016) Zachary Oaks et al.   Current Rheumatology Reports

Immune Cell Metabolism in Systemic Lupus Erythematosus

(2016) Seung-Chul Choi et al.   Current Rheumatology Reports

Epigenetic Reprogramming in Naive CD4+ T Cells Favoring T Cell Activation and Non-Th1 Effector T Cell Immune Response as an Early Event in Lupus Flares

(2016) Patrick Coit et al.   Arthritis & Rheumatology

HIV infection results in metabolic alterations in the gut microbiota different from those induced by other diseases

(2016) Sergio Serrano-Villar et al.   Scientific Reports

Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients

(2016) Patricia López et al.   Scientific Reports

Liver X receptors in immune cell function in humans: Figure 1

(2015) Kirsty E. Waddington et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Constitutive activities of estrogen-related receptors: Transcriptional regulation of metabolism by the ERR pathways in health and disease

(2015) Janice M. Huss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sirolimus is effective in relapsed/refractory autoimmune cytopenias: results of a prospective multi-institutional trial

(2015) K. L. Bride et al.   BLOOD

SnapShot: Immunometabolism

(2015) Peter J. Murray et al.   Cell Metabolism

Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

(2015) Qingyu Zeng et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Autophagy inhibitors

(2015) Benoit Pasquier   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of neutrophils in the pathogenesis of systemic lupus erythematosus

(2015) Carolyne K. Smith et al.   CURRENT OPINION IN RHEUMATOLOGY

Lipopolysaccharide induces inducible nitric oxide synthase-dependent podocyte dysfunction via a hypoxia-inducible factor 1α and cell division control protein 42 and Ras-related C3 botulinum toxin substrate 1 pathway

(2015) Ahmad K. Mashmoushi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses

(2015) Martin Kolev et al.   IMMUNITY

HDAC expression and activity is upregulated in diseased lupus-prone mice

(2015) Nicole L. Regna et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

(2015) Yi Bao et al.   JOURNAL OF CELL BIOLOGY

T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity

(2015) Vaishali R. Moulton et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain

(2015) Kamala P. Sundararaj et al.   JOURNAL OF IMMUNOLOGY

The Immune-Metabolic Basis of Effector Memory CD4+T Cell Function under Hypoxic Conditions

(2015) Sarah Dimeloe et al.   JOURNAL OF IMMUNOLOGY

Glucose Oxidation Is Critical for CD4+T Cell Activation in a Mouse Model of Systemic Lupus Erythematosus

(2015) Yiming Yin et al.   JOURNAL OF IMMUNOLOGY

Comprehensive metabolome analyses reveal N-acetylcysteine-responsive accumulation of kynurenine in systemic lupus erythematosus: implications for activation of the mechanistic target of rapamycin

(2015) Andras Perl et al.   Metabolomics

Sterol metabolism controls T H 17 differentiation by generating endogenous RORγ agonists

(2015) Xiao Hu et al.   Nature Chemical Biology

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction

(2015) Ende Zhao et al.   NATURE IMMUNOLOGY

What is damaging the kidney in lupus nephritis?

(2015) Anne Davidson   Nature Reviews Rheumatology

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity

(2015) Buvana Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normalization of CD4 + T cell metabolism reverses lupus

(2015) Yiming Yin et al.   Science Translational Medicine

Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression

(2015) Pedro Mejia et al.   Nature Communications

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

(2015) Alvin Pratama et al.   Nature Communications

IDO-GCN2 and autophagy in inflammation

(2015) Tracy L. McGaha   Oncotarget

Ranking the impact of human health disorders on gut metabolism: Systemic lupus erythematosus and obesity as study cases

(2015) David Rojo et al.   Scientific Reports

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

(2015) Roybel R Ramiscal et al.   eLife

Type I Interferon-Mediated Skewing of the Serotonin Synthesis Is Associated with Severe Disease in Systemic Lupus Erythematosus

(2015) Christian Lood et al.   PLoS One

Hypoxia Inducible Factor-1 Alpha Promotes Mesangial Cell Proliferation in Lupus Nephritis

(2014) Wei Deng et al.   AMERICAN JOURNAL OF NEPHROLOGY

Increased Mitochondrial Electron Transport Chain Activity at Complex I Is Regulated by N-Acetylcysteine in Lymphocytes of Patients with Systemic Lupus Erythematosus

(2014) Edward Doherty et al.   ANTIOXIDANTS & REDOX SIGNALING

The Glucose Transporter Glut1 Is Selectively Essential for CD4 T Cell Activation and Effector Function

(2014) Andrew N. Macintyre et al.   Cell Metabolism

Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus

(2014) Tamar R. Aprahamian et al.   IMMUNOLOGY

Lipids rule: resetting lipid metabolism restores T cell function in systemic lupus erythematosus

(2014) Yoko Kidani et al.   JOURNAL OF CLINICAL INVESTIGATION

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholera Toxin B Accelerates Disease Progression in Lupus-Prone Mice by Promoting Lipid Raft Aggregation

(2014) G.-M. Deng et al.   JOURNAL OF IMMUNOLOGY

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

The Peroxisome Proliferator-Activated Receptor   Agonist Rosiglitazone Ameliorates Murine Lupus by Induction of Adiponectin

(2014) T. Aprahamian et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Renal Glycosphingolipid Metabolism Is Dysfunctional in Lupus Nephritis

(2014) T. K. Nowling et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resistin is associated with the inflammation process in patients with systemic autoimmune diseases undergoing glucocorticoid therapy: comparison with leptin and adiponectin

(2014) Nahoko Tanaka et al.   Modern Rheumatology

mTOR Activation Promotes Plasma Cell Differentiation and Bypasses XBP-1 for Immunoglobulin Secretion

(2014) Sandrine Benhamron et al.   MOLECULAR AND CELLULAR BIOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

DNA methylation and miRNA—key roles in systemic autoimmunity

(2014) Bruce C. Richardson et al.   Nature Reviews Rheumatology

Statins: From cholesterol-lowering drugs to novel immunomodulators for the treatment of Th17-mediated autoimmune diseases

(2014) Cristina Ulivieri et al.   PHARMACOLOGICAL RESEARCH

Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans

(2014) Ja-Young Jeon et al.   ARTHRITIS RESEARCH & THERAPY

Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

(2014) A. Hevia et al.   mBio

Identification of Stage-Specific Genes Associated With Lupus Nephritis and Response to Remission Induction in (NZB × NZW)F1 and NZM2410 Mice

(2014) Ramalingam Bethunaickan et al.   Arthritis & Rheumatology

Metabolic control of the epigenome in systemic Lupus erythematosus

(2013) Zachary Oaks et al.   AUTOIMMUNITY

The peroxisome-proliferator activated receptor-γ agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus

(2013) Wenpu Zhao et al.   CLINICAL IMMUNOLOGY

Lack of association between the polymorphisms of hypoxia-inducible factor 1A (HIF1A) gene and SLE susceptibility in a Chinese population

(2013) Chen-Chen Feng et al.   IMMUNOGENETICS

Tuberous Sclerosis and Fulminant Lupus in a Young Woman

(2013) Namrata Singh et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus

(2013) Z.-W. Lai et al.   JOURNAL OF IMMUNOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Oxidative stress in the pathology and treatment of systemic lupus erythematosus

(2013) Andras Perl   Nature Reviews Rheumatology

Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosphingolipid Metabolism

(2013) Erin Morris Richard et al.   PLoS One

Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

(2012) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Metabolic regulation of organelle homeostasis in lupus T cells

(2012) Tiffany N. Caza et al.   CLINICAL IMMUNOLOGY

Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration

(2012) Theresa Köhler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4+ T Cell Activation and Maps to Estrogen-Related Receptor  

(2012) D. J. Perry et al.   JOURNAL OF IMMUNOLOGY

Taming lupus—a new understanding of pathogenesis is leading to clinical advances

(2012) Zheng Liu et al.   NATURE MEDICINE

Follicular helper T cells in immunity and systemic autoimmunity

(2012) Joseph E. Craft   Nature Reviews Rheumatology

Metabolic Disturbances Associated with Systemic Lupus Erythematosus

(2012) Tianfu Wu et al.   PLoS One

Molecular Characterization of Circulating Plasma Cells in Patients with Active Systemic Lupus Erythematosus

(2012) Patricia L. Lugar et al.   PLoS One

Tolerance to apoptotic cells is regulated by indoleamine 2,3-dioxygenase

(2012) B. Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

Mycophenolic Acid-Mediated Suppression of Human CD4+ T Cells: More Than Mere Guanine Nucleotide Deprivation

(2011) X. He et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

(2011) Guoliang Cui et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

IFN-  and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells

(2011) H. Le Buanec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase

(2011) Andras Perl et al.   TRENDS IN MOLECULAR MEDICINE

Defective response of CD4+ T cells to retinoic acid and TGFβ in systemic lupus erythematosus

(2011) Eric S Sobel et al.   ARTHRITIS RESEARCH & THERAPY

Characterization of the metabolic phenotype of chronically activated lymphocytes

(2010) DR Wahl et al.   LUPUS

The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin

(2010) Kostas Stylianou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis

(2010) Erin E Morris et al.   ARTHRITIS RESEARCH & THERAPY

Rosiglitazone decreases blood pressure and renal injury in a female mouse model of systemic lupus erythematosus

(2009) Marcia Venegas-Pont et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Association of UCP2 −866 G/A polymorphism with chronic inflammatory diseases

(2009) X Yu et al.   GENES AND IMMUNITY

The Peroxisome Proliferator-Activated Receptor   Agonist Pioglitazone Improves Cardiometabolic Risk and Renal Inflammation in Murine Lupus

(2009) W. Zhao et al.   JOURNAL OF IMMUNOLOGY

Activation of Mammalian Target of Rapamycin Controls the Loss of TCR  in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

(2009) D. R. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Metabolic control of T cell activation and death in SLE

(2008) David Fernandez et al.   AUTOIMMUNITY REVIEWS

Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus

(2008) Tamara Vyshkina et al.   CLINICAL IMMUNOLOGY

Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid

(2008) Sophie Domhan et al.   MOLECULAR CANCER THERAPEUTICS

Rapamycin attenuates the severity of established nephritis in lupus-prone NZB/W F1 mice

(2008) S. L. Lui et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION