Taming lupus—a new understanding of pathogenesis is leading to clinical advances

Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

(2014) J. C. Crispin et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL

(2014) M. J. Benson et al.   JOURNAL OF IMMUNOLOGY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

(2011) E. Sanchez et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeted therapies in systemic lupus erythematosus: successes, failures and future

(2011) B. H. Hahn   ANNALS OF THE RHEUMATIC DISEASES

Current state and future directions of autologous hematopoietic stem cell transplantation in systemic lupus erythematosus

(2011) G. G. Illei et al.   ANNALS OF THE RHEUMATIC DISEASES

Trafficking of B Cell Antigen in Lymph Nodes

(2011) Santiago F. Gonzalez et al.   Annual Review of Immunology

Nucleic Acid Recognition by the Innate Immune System

(2011) Roman Barbalat et al.   Annual Review of Immunology

Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long-term serial adipose tissue-derived mesenchymal stem cell transplantation

(2011) Eun Wha Choi et al.   ARTHRITIS AND RHEUMATISM

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Use of atorvastatin in systemic lupus erythematosus in children and adolescents

(2011) L. E. Schanberg et al.   ARTHRITIS AND RHEUMATISM

Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosus

(2011) Vasileios C. Kyttaris et al.   CURRENT OPINION IN RHEUMATOLOGY

BAFF inhibition: A new class of drugs for the treatment of autoimmunity

(2011) Zheng Liu et al.   EXPERIMENTAL CELL RESEARCH

Recent advances in the genetics of systemic lupus erythematosus

(2011) Donna L Thibault Flesher et al.   Expert Review of Clinical Immunology

Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention

(2011) Maureen McMahon et al.   Expert Review of Clinical Immunology

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

A Unique Hybrid Renal Mononuclear Phagocyte Activation Phenotype in Murine Systemic Lupus Erythematosus Nephritis

(2011) R. Bethunaickan et al.   JOURNAL OF IMMUNOLOGY

Systemic lupus erythematosus, the brain, and anti-NR2 antibodies

(2011) Maria B. Lauvsnes et al.   JOURNAL OF NEUROLOGY

The Emergence of Th17 Cells as Effectors of Renal Injury

(2011) A. R. Kitching et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury

(2011) Brandon Renner et al.   KIDNEY INTERNATIONAL

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Current state of evidence on ‘off-label’ therapeutic options for systemic lupus erythematosus, including biological immunosuppressive agents, in Germany, Austria and Switzerland – a consensus report

(2011) M Aringer et al.   LUPUS

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

Treg cells: patrolling a dangerous neighborhood

(2011) Daniel J Campbell et al.   NATURE MEDICINE

Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE

(2011) Deborah P. M. Symmons et al.   Nature Reviews Rheumatology

Generation of a unique small molecule peptidomimetic that neutralizes lupus autoantibody activity

(2011) O. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD8+T regulatory cells express the Ly49 Class I MHC receptor and are defective in autoimmune prone B6-Yaa mice

(2011) Hye-Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

(2011) Rujuan Dai et al.   Translational Research

BAFF and selection of autoreactive B cells

(2011) Zheng Liu et al.   TRENDS IN IMMUNOLOGY

Abnormalities of T cell signaling in systemic lupus erythematosus

(2011) Vaishali R Moulton et al.   ARTHRITIS RESEARCH & THERAPY

MicroRNAs in systemic rheumatic diseases

(2011) Angela Ceribelli et al.   ARTHRITIS RESEARCH & THERAPY

Risk Alleles for Systemic Lupus Erythematosus in a Large Case-Control Collection and Associations with Clinical Subphenotypes

(2011) Kimberly E. Taylor et al.   PLoS Genetics

Prioritizing GWAS Results: A Review of Statistical Methods and Recommendations for Their Application

(2010) Rita M. Cantor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lupus Atherosclerosis Prevention Study (LAPS)

(2010) M. A. Petri et al.   ANNALS OF THE RHEUMATIC DISEASES

Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study

(2010) J. Liang et al.   ANNALS OF THE RHEUMATIC DISEASES

Systemic lupus erythematosus monocytes are less responsive to interleukin-10 in the presence of immune complexes

(2010) Weijia Yuan et al.   ARTHRITIS AND RHEUMATISM

Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice

(2010) Guo-Min Deng et al.   ARTHRITIS AND RHEUMATISM

Lupus T cells switched on by DNA hypomethylation via microRNA?

(2010) Angela Ceribelli et al.   ARTHRITIS AND RHEUMATISM

Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV

(2010) Kunihiro Ichinose et al.   ARTHRITIS AND RHEUMATISM

Genetic and hormonal factors in female-biased autoimmunity

(2010) Anatoly V. Rubtsov et al.   AUTOIMMUNITY REVIEWS

Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFRβ, chemotaxis and TNFα production

(2010) Brian J. Skaggs et al.   CLINICAL IMMUNOLOGY

Biologics in the treatment of systemic lupus erythematosus

(2010) Aisha Lateef et al.   CURRENT OPINION IN RHEUMATOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Biomarkers for Lupus Nephritis: A Critical Appraisal

(2010) Chi Chiu Mok   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The Detrimental Effects of IFN-  on Vasculogenesis in Lupus Are Mediated by Repression of IL-1 Pathways: Potential Role in Atherogenesis and Renal Vascular Rarefaction

(2010) S. G. Thacker et al.   JOURNAL OF IMMUNOLOGY

The endothelium: an interface between autoimmunity and atherosclerosis in systemic lupus erythematosus?

(2010) CB Narshi et al.   LUPUS

Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9

(2010) Petar S. Lenert   MEDIATORS OF INFLAMMATION

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

Control systems and decision making for antibody production

(2010) Christopher C Goodnow et al.   NATURE IMMUNOLOGY

Basophils and the T helper 2 environment can promote the development of lupus nephritis

(2010) Nicolas Charles et al.   NATURE MEDICINE

T cells as therapeutic targets in SLE

(2010) José C. Crispín et al.   Nature Reviews Rheumatology

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

Pathogenesis of ankylosing spondylitis

(2010) Lai-Shan Tam et al.   Nature Reviews Rheumatology

Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms

(2010) T. W. Faust et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Urinary neutrophil gelatinase-associated lipocalin as a novel biomarker for disease activity in lupus nephritis

(2010) T. Rubinstein et al.   RHEUMATOLOGY

Interferon-α treatment of female (NZW × BXSB)F1mice mimics some but not all features associated with theYaamutation

(2009) Meera Ramanujam et al.   ARTHRITIS AND RHEUMATISM

Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus

(2009) Maureen McMahon et al.   ARTHRITIS AND RHEUMATISM

Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study

(2009) Jason W. Bauer et al.   ARTHRITIS AND RHEUMATISM

Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity

(2009) Claas H. Hinze et al.   ARTHRITIS AND RHEUMATISM

Effect of long-term belimumab treatment on b cells in systemic lupus erythematosus: Extension of a phase II, double-blind, placebo-controlled, dose-ranging study

(2009) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

T-cell and B-cell signaling biomarkers and treatment targets in lupus

(2009) Andras Perl et al.   CURRENT OPINION IN RHEUMATOLOGY

Kallikrein genes are associated with lupus and glomerular basement membrane–specific antibody–induced nephritis in mice and humans

(2009) Kui Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular helper T cells are required for systemic autoimmunity

(2009) Michelle A. Linterman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease

(2009) H. Agrawal et al.   JOURNAL OF IMMUNOLOGY

Immunoregulatory role of TNFα in inflammatory kidney diseases

(2009) Thomas Ernandez et al.   KIDNEY INTERNATIONAL

A perspective on B-cell-targeting therapy for SLE

(2009) R. John Looney et al.   Modern Rheumatology

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

(2008) Frances Rena Bahjat et al.   ARTHRITIS AND RHEUMATISM

DNase 1 and systemic lupus erythematosus

(2008) Fernando Martínez Valle et al.   AUTOIMMUNITY REVIEWS

Mechanisms of kidney fibrosis and the role of antifibrotic therapies

(2008) Leo Deelman et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Targeting of the immune system in systemic lupus erythematosus

(2008) Meera Ramanujam et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus

(2008) Damien Chaussabel et al.   IMMUNITY

Distinct cell-specific control of autoimmunity and infection by FcγRIIb

(2008) Rebecca J. Brownlie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

(2008) Jared M. Odegard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts

(2008) Sun Jung Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

(2008) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A role for sex chromosome complement in the female bias in autoimmune disease

(2008) Deborah L. Smith-Bouvier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Overview of factors contributing to the pathophysiology of progressive renal disease

(2008) Detlef O. Schlondorff   KIDNEY INTERNATIONAL

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis?

(2008) Tri Q. Nguyen et al.   PHARMACEUTICAL RESEARCH

Epigenetic regulation and the pathogenesis of systemic lupus erythematosus

(2008) Yujun Pan et al.   Translational Research

Mechanisms of Disease: antiphospholipid antibodies—from clinical association to pathologic mechanism

(2008) Bas de Laat et al.   Nature clinical practice. Rheumatology