Metabolic Control of Plasma Cell Differentiation- What We Know and What We Don't Know

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

(2016) Martina Minnich et al.   NATURE IMMUNOLOGY

Lipid-dependent regulation of the unfolded protein response

(2015) Romain Volmer et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma

(2015) Prahlad V. Raninga et al.   Oncotarget

KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models

(2015) Irene Riz et al.   Oncotarget

Combined autophagy and proteasome inhibition

(2014) Dan T Vogl et al.   Autophagy

High XBP1 expression is a marker of better outcome in multiple myeloma patients treated with bortezomib

(2014) M. Gambella et al.   HAEMATOLOGICA

Transcription Factor IRF4 Regulates Germinal Center Cell Formation through a B Cell-Intrinsic Mechanism

(2014) S. N. Willis et al.   JOURNAL OF IMMUNOLOGY

mTOR Activation Promotes Plasma Cell Differentiation and Bypasses XBP-1 for Immunoglobulin Secretion

(2014) Sandrine Benhamron et al.   MOLECULAR AND CELLULAR BIOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition

(2014) Jose J. Limon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells

(2013) Sandrine Benhamron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

(2013) Kyoko Ochiai et al.   IMMUNITY

Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma

(2013) L. Vincenz et al.   MOLECULAR CANCER THERAPEUTICS

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

On the Redox Control of B Lymphocyte Differentiation and Function

(2012) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency

(2012) N. Taubenheim et al.   JOURNAL OF IMMUNOLOGY

Alternate pathways for Bcl6-mediated regulation of B cell to plasma cell differentiation

(2011) Jukka Alinikula et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

The genetic network controlling plasma cell differentiation

(2011) Stephen L. Nutt et al.   SEMINARS IN IMMUNOLOGY

B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses

(2010) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch

(2010) Akihiko Muto et al.   EMBO JOURNAL

Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling

(2010) Meidan Goldfinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response

(2009) Yanjun Ma et al.   CELL STRESS & CHAPERONES

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

(2009) Chih-Chi Andrew Hu et al.   EMBO JOURNAL

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing

(2009) Kathleen Martincic et al.   NATURE IMMUNOLOGY

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6

(2008) K. Ochiai et al.   INTERNATIONAL IMMUNOLOGY